Donor‐Specific Antibodies Are Produced Locally in Ectopic Lymphoid Structures in Cardiac Allografts

Cardiac allograft vasculopathy (CAV) is a transplant pathology, limiting graft survival after heart transplantation. CAV arteries are surrounded by ectopic lymphoid structures (ELS) containing B cells and plasma cells. The aim of this study was to characterize the antigenic targets of antibodies pro...

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Veröffentlicht in:	American journal of transplantation 2017-01, Vol.17 (1), p.246-254
Hauptverfasser:	Huibers, M. M. H., Gareau, A. J., Beerthuijzen, J. M. T., Siera‐de Koning, E., Kuik, J., Kamburova, E. G., Vink, A., Jonge, N., Lee, T. D. G., Otten, H. G., Weger, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	alloantibody Allografts Autopsy B cell biology Cell proliferation Coronary artery Coronary vessels CXCR3 protein Cytokines Female Graft rejection Graft Rejection - etiology Graft Rejection - pathology Graft Survival - immunology Heart transplantation Heart Transplantation - adverse effects heart transplantation/cardiology Heart transplants Histocompatibility antigen HLA Histocompatibility Testing Humans Immunofluorescence Immunoglobulin G Immunoglobulin M Immunoglobulins Interferon Isoantibodies - blood Isoantibodies - immunology Lymphocytes B Lymphocytes T Lymphoid Tissue - immunology Lysates Male molecular biology pathology/histopathology Plasma Plasma cells Polymerase chain reaction Prognosis rejection: antibody‐mediated (ABMR) rejection: chronic Risk Factors Tissue Donors translational research/science Transplants & implants Vascular diseases vasculopathy Veins & arteries
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