An O‐Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin

ABSTRACT Patients with cholestatic liver disease experience increased fracture risk. Higher circulating levels of a fibronectin isoform called oncofetal fibronectin (oFN) were detected in a subset of such patients. Administering this isoform to mice suppresses osteoblast differentiation and diminish...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2017-01, Vol.32 (1), p.70-81
Hauptverfasser:	Sens, Carla, Altrock, Eva, Rau, Katrin, Klemis, Verena, von Au, Anja, Pettera, Stefan, Uebel, Stephan, Damm, Timo, Tiwari, Sanjay, Moser, Markus, Nakchbandi, Inaam A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Bone Diseases - complications Bone Diseases - metabolism Disease Models, Animal FIBRONECTIN Fibronectins - administration & dosage Fibronectins - metabolism Glycosylation HEPATIC OSTEODYSTROPHY Humans Integrin alpha4beta1 - metabolism INTEGRIN α4β1 Liver Cirrhosis - complications Liver Cirrhosis - metabolism Mice OSTEOBLAST DIFFERENTIATION Osteoblasts - metabolism OSTEOPOROSIS Peptides - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!