Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation
Cirrhosis is a consequence of prolonged liver injury and is characterised by extensive tissue fibrosis: the deposition of collagen-rich extracellular matrix. The haemostatic balance is disordered in cirrhosis and coagulation activation appears to promote fibrosis. In spite of recent studies demonstr...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2017-01, Vol.43 (1), p.54-59 |
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| creator | Egan, Karl Dillon, Audrey Dunne, Eimear Kevane, Barry Galvin, Zita Maguire, Patricia Kenny, Dermot Stewart, Stephen Ainle, Fionnuala Ni |
| description | Cirrhosis is a consequence of prolonged liver injury and is characterised by extensive tissue fibrosis: the deposition of collagen-rich extracellular matrix. The haemostatic balance is disordered in cirrhosis and coagulation activation appears to promote fibrosis. In spite of recent studies demonstrating a role for anticoagulant therapy in preventing cirrhosis progression, there has not been a change in clinical practice, suggesting that physicians are reluctant to anticoagulate patients with cirrhosis due to bleeding risks. Platelets play an important role in facilitating coagulation. Glycoprotein VI (GPVI) is a platelet-specific collagen receptor that is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligation and coagulation activation. Our aim was to use soluble GPVI levels to determine whether there was evidence for collagen and coagulation-induced platelet activation in early, well-compensated cirrhosis. Plasma soluble GPVI levels were quantified in 46 patients with mixed aetiology cirrhosis and 55 healthy controls using an immunoassay. In the cirrhosis group, soluble GPVI levels were significantly increased (5.8 ± 4.4 ng/ml, n = 46) compared to healthy controls (3.3 ± 3.4 ng/ml, n = 55, p |
| doi_str_mv | 10.1007/s11239-016-1401-0 |
| format | Article |
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6
platelets/ml vs. cirrhosis; 0.048 ± 0.04 ng/10
6
platelets/ml, p < 0.0001). This study provides evidence for early platelet activation in patients with well-compensated cirrhosis. This may have translational implications for prognosis, treatment, and risk stratification.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-016-1401-0</identifier><identifier>PMID: 27416950</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Cardiology ; Case-Control Studies ; Female ; Hematology ; Humans ; Liver Cirrhosis - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Platelet Activation ; Platelet Count ; Platelet Membrane Glycoproteins - analysis ; Platelet Membrane Glycoproteins - physiology ; Solubility</subject><ispartof>Journal of thrombosis and thrombolysis, 2017-01, Vol.43 (1), p.54-59</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Journal of Thrombosis and Thrombolysis is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-5e9ff3bfd15f1b436a4bbb4aea00c55d8fd4e948508ec4c018c9c2e046122a1b3</citedby><cites>FETCH-LOGICAL-c438t-5e9ff3bfd15f1b436a4bbb4aea00c55d8fd4e948508ec4c018c9c2e046122a1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-016-1401-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-016-1401-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27416950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egan, Karl</creatorcontrib><creatorcontrib>Dillon, Audrey</creatorcontrib><creatorcontrib>Dunne, Eimear</creatorcontrib><creatorcontrib>Kevane, Barry</creatorcontrib><creatorcontrib>Galvin, Zita</creatorcontrib><creatorcontrib>Maguire, Patricia</creatorcontrib><creatorcontrib>Kenny, Dermot</creatorcontrib><creatorcontrib>Stewart, Stephen</creatorcontrib><creatorcontrib>Ainle, Fionnuala Ni</creatorcontrib><title>Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Cirrhosis is a consequence of prolonged liver injury and is characterised by extensive tissue fibrosis: the deposition of collagen-rich extracellular matrix. The haemostatic balance is disordered in cirrhosis and coagulation activation appears to promote fibrosis. In spite of recent studies demonstrating a role for anticoagulant therapy in preventing cirrhosis progression, there has not been a change in clinical practice, suggesting that physicians are reluctant to anticoagulate patients with cirrhosis due to bleeding risks. Platelets play an important role in facilitating coagulation. Glycoprotein VI (GPVI) is a platelet-specific collagen receptor that is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligation and coagulation activation. Our aim was to use soluble GPVI levels to determine whether there was evidence for collagen and coagulation-induced platelet activation in early, well-compensated cirrhosis. Plasma soluble GPVI levels were quantified in 46 patients with mixed aetiology cirrhosis and 55 healthy controls using an immunoassay. In the cirrhosis group, soluble GPVI levels were significantly increased (5.8 ± 4.4 ng/ml, n = 46) compared to healthy controls (3.3 ± 3.4 ng/ml, n = 55, p < 0.05). This increase in soluble GPVI levels was still evident when levels were adjusted for platelet count (Healthy controls; 0.015 ± 0.018 ng/10
6
platelets/ml vs. cirrhosis; 0.048 ± 0.04 ng/10
6
platelets/ml, p < 0.0001). This study provides evidence for early platelet activation in patients with well-compensated cirrhosis. This may have translational implications for prognosis, treatment, and risk stratification.</description><subject>Aged</subject><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Liver Cirrhosis - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Platelet Activation</subject><subject>Platelet Count</subject><subject>Platelet Membrane Glycoproteins - analysis</subject><subject>Platelet Membrane Glycoproteins - physiology</subject><subject>Solubility</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMFu1DAQhi1ERbeFB-CCLHHhEphx7CTmhipoV6pEDy1CXCzHmYArb7zYSaS-PV5tQQiJ0xzm-_8ZfYy9RHiLAO27jChqXQE2FUrACp6wDaq2rlopvj5lG9BCV6oGdcrOcr4HAK1BPGOnopXYaAUb9m07uUQ208BzDEsfiF_efNnyQCuFzP3EnU_pR8w-v-e0-oEmR3yMiZNN4eEArH6NfB_sTIFmbt3sVzv7OD1nJ6MNmV48znN29-nj7cVVdf35cnvx4bpysu7mSpEex7ofB1Qj9rJurOz7XlqyAE6poRsHSVp2Cjpy0gF2TjtBIBsUwmJfn7M3x959ij8XyrPZ-ewoBDtRXLLBTjStkKhkQV__g97HJU3lu0KpDkp5owuFR8qlmHOi0eyT39n0YBDMQbw5ijdFvDmIN1Ayrx6bl35Hw5_Eb9MFEEcgl9X0ndJfp__b-guje43I</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Egan, Karl</creator><creator>Dillon, Audrey</creator><creator>Dunne, Eimear</creator><creator>Kevane, Barry</creator><creator>Galvin, Zita</creator><creator>Maguire, Patricia</creator><creator>Kenny, Dermot</creator><creator>Stewart, Stephen</creator><creator>Ainle, Fionnuala Ni</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation</title><author>Egan, Karl ; Dillon, Audrey ; Dunne, Eimear ; Kevane, Barry ; Galvin, Zita ; Maguire, Patricia ; Kenny, Dermot ; Stewart, Stephen ; Ainle, Fionnuala Ni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-5e9ff3bfd15f1b436a4bbb4aea00c55d8fd4e948508ec4c018c9c2e046122a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Liver Cirrhosis - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Platelet Activation</topic><topic>Platelet Count</topic><topic>Platelet Membrane Glycoproteins - analysis</topic><topic>Platelet Membrane Glycoproteins - physiology</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egan, Karl</creatorcontrib><creatorcontrib>Dillon, Audrey</creatorcontrib><creatorcontrib>Dunne, Eimear</creatorcontrib><creatorcontrib>Kevane, Barry</creatorcontrib><creatorcontrib>Galvin, Zita</creatorcontrib><creatorcontrib>Maguire, Patricia</creatorcontrib><creatorcontrib>Kenny, Dermot</creatorcontrib><creatorcontrib>Stewart, Stephen</creatorcontrib><creatorcontrib>Ainle, Fionnuala Ni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egan, Karl</au><au>Dillon, Audrey</au><au>Dunne, Eimear</au><au>Kevane, Barry</au><au>Galvin, Zita</au><au>Maguire, Patricia</au><au>Kenny, Dermot</au><au>Stewart, Stephen</au><au>Ainle, Fionnuala Ni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>43</volume><issue>1</issue><spage>54</spage><epage>59</epage><pages>54-59</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Cirrhosis is a consequence of prolonged liver injury and is characterised by extensive tissue fibrosis: the deposition of collagen-rich extracellular matrix. The haemostatic balance is disordered in cirrhosis and coagulation activation appears to promote fibrosis. In spite of recent studies demonstrating a role for anticoagulant therapy in preventing cirrhosis progression, there has not been a change in clinical practice, suggesting that physicians are reluctant to anticoagulate patients with cirrhosis due to bleeding risks. Platelets play an important role in facilitating coagulation. Glycoprotein VI (GPVI) is a platelet-specific collagen receptor that is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligation and coagulation activation. Our aim was to use soluble GPVI levels to determine whether there was evidence for collagen and coagulation-induced platelet activation in early, well-compensated cirrhosis. Plasma soluble GPVI levels were quantified in 46 patients with mixed aetiology cirrhosis and 55 healthy controls using an immunoassay. In the cirrhosis group, soluble GPVI levels were significantly increased (5.8 ± 4.4 ng/ml, n = 46) compared to healthy controls (3.3 ± 3.4 ng/ml, n = 55, p < 0.05). This increase in soluble GPVI levels was still evident when levels were adjusted for platelet count (Healthy controls; 0.015 ± 0.018 ng/10
6
platelets/ml vs. cirrhosis; 0.048 ± 0.04 ng/10
6
platelets/ml, p < 0.0001). This study provides evidence for early platelet activation in patients with well-compensated cirrhosis. This may have translational implications for prognosis, treatment, and risk stratification.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27416950</pmid><doi>10.1007/s11239-016-1401-0</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Cardiology Case-Control Studies Female Hematology Humans Liver Cirrhosis - blood Male Medicine Medicine & Public Health Middle Aged Platelet Activation Platelet Count Platelet Membrane Glycoproteins - analysis Platelet Membrane Glycoproteins - physiology Solubility |
| title | Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation |
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