Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life
Extremely low birth weight (ELBW;
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| Veröffentlicht in: | Development and psychopathology 2017-08, Vol.29 (3), p.837-843 |
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| container_title | Development and psychopathology |
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| creator | Lahat, Ayelet van Lieshout, Ryan J. Mathewson, Karen J. Mackillop, James Saigal, Saroj Morrison, Katherine M. Boyle, Michael H. Schmidt, Louis A. |
| description | Extremely low birth weight (ELBW; |
| doi_str_mv | 10.1017/S0954579416000511 |
| format | Article |
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Even greater early adversity has been experienced by ELBW survivors who were also born small for gestational age (SGA; <10th percentile for GA) compared to those born appropriate for GA (AGA). ELBW survivors, particularly those born SGA, face increased risk for internalizing problems compared to normal BW (NBW; ≥2500 g) controls. Internalizing problems are related to allelic variations in the promoter region of the serotonin transporter linked polymorphic region gene (5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology.</description><identifier>ISSN: 0954-5794</identifier><identifier>EISSN: 1469-2198</identifier><identifier>DOI: 10.1017/S0954579416000511</identifier><identifier>PMID: 27416920</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Adult ; Adults ; Age ; Anxiety ; Attention deficit hyperactivity disorder ; Babies ; Birth weight ; Dental Anxiety - etiology ; Depression - etiology ; Female ; Gene-Environment Interaction ; Gestational age ; Humans ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infants ; Intensive care ; Intrauterine exposure ; Low birth weight ; Male ; Mental depression ; Pediatrics ; Psychiatry ; Psychopathology ; Regular Articles ; Self Report ; Serotonin ; Serotonin Plasma Membrane Transport Proteins - genetics ; Serotonin transporter ; Small for gestational age ; Stress ; Survivors ; Young Adult</subject><ispartof>Development and psychopathology, 2017-08, Vol.29 (3), p.837-843</ispartof><rights>Copyright © Cambridge University Press 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-f1fdcbe1ea4ff4ac4296fd9645e3eb31398a9fc6291774e9307f4079332eb4d43</citedby><cites>FETCH-LOGICAL-c373t-f1fdcbe1ea4ff4ac4296fd9645e3eb31398a9fc6291774e9307f4079332eb4d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0954579416000511/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27416920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lahat, Ayelet</creatorcontrib><creatorcontrib>van Lieshout, Ryan J.</creatorcontrib><creatorcontrib>Mathewson, Karen J.</creatorcontrib><creatorcontrib>Mackillop, James</creatorcontrib><creatorcontrib>Saigal, Saroj</creatorcontrib><creatorcontrib>Morrison, Katherine M.</creatorcontrib><creatorcontrib>Boyle, Michael H.</creatorcontrib><creatorcontrib>Schmidt, Louis A.</creatorcontrib><title>Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life</title><title>Development and psychopathology</title><addtitle>Dev Psychopathol</addtitle><description>Extremely low birth weight (ELBW; <1000 g) infants have been exposed to stressful intrauterine and early postnatal environments. Even greater early adversity has been experienced by ELBW survivors who were also born small for gestational age (SGA; <10th percentile for GA) compared to those born appropriate for GA (AGA). ELBW survivors, particularly those born SGA, face increased risk for internalizing problems compared to normal BW (NBW; ≥2500 g) controls. Internalizing problems are related to allelic variations in the promoter region of the serotonin transporter linked polymorphic region gene (5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Anxiety</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Dental Anxiety - etiology</subject><subject>Depression - etiology</subject><subject>Female</subject><subject>Gene-Environment Interaction</subject><subject>Gestational age</subject><subject>Humans</subject><subject>Infant, Extremely Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Intensive care</subject><subject>Intrauterine exposure</subject><subject>Low birth weight</subject><subject>Male</subject><subject>Mental depression</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Psychopathology</subject><subject>Regular Articles</subject><subject>Self Report</subject><subject>Serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Serotonin transporter</subject><subject>Small for gestational age</subject><subject>Stress</subject><subject>Survivors</subject><subject>Young Adult</subject><issn>0954-5794</issn><issn>1469-2198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1Uctu1DAUtRAVHQofwAZZYsMmYMdOHLNDVSlIlboorCPHvp5xldiD7XRoV_0G-EO-BEczVAjEwrJ07nncq4PQC0reUELF2ysiG94IyWlLCGkofYRWlLeyqqnsHqPVMq6W-TF6mtL1wmG8eYKOa1EksiYr9P3sW44wwXiLx7DDg4t5g3fg1puMBzU4SHgdw87jefsOn4OHn_c_wN-4GPwEPmPnM0SlswsebyMYp3Pag16N7s75dYHDMMK0wDhvoDwXDVbeYBvmJc6AVqYEBYtHZ-EZOrJqTPD88J-gLx_OPp9-rC4uzz-dvr-oNBMsV5ZaowegoLi1XGley9Ya2fIGGAyMMtkpaXVbSyoEB8mIsJwIyVgNAzecnaDXe9-y4NcZUu4nlzSMo_IQ5tTTrm5FzTrZFeqrv6jXZfVyYWFJ2hXbrl4M6Z6lY0gpgu230U0q3vaU9Eth_T-FFc3Lg_M8TGAeFL8bKgR2MFXTEJ1Zwx_Z_7X9BeK1ozQ</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Lahat, Ayelet</creator><creator>van Lieshout, Ryan J.</creator><creator>Mathewson, Karen J.</creator><creator>Mackillop, James</creator><creator>Saigal, Saroj</creator><creator>Morrison, Katherine M.</creator><creator>Boyle, Michael H.</creator><creator>Schmidt, Louis A.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K7.</scope><scope>K9.</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life</title><author>Lahat, Ayelet ; van Lieshout, Ryan J. ; Mathewson, Karen J. ; Mackillop, James ; Saigal, Saroj ; Morrison, Katherine M. ; Boyle, Michael H. ; Schmidt, Louis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-f1fdcbe1ea4ff4ac4296fd9645e3eb31398a9fc6291774e9307f4079332eb4d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Anxiety</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Dental Anxiety - etiology</topic><topic>Depression - etiology</topic><topic>Female</topic><topic>Gene-Environment Interaction</topic><topic>Gestational age</topic><topic>Humans</topic><topic>Infant, Extremely Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Intrauterine exposure</topic><topic>Low birth weight</topic><topic>Male</topic><topic>Mental depression</topic><topic>Pediatrics</topic><topic>Psychiatry</topic><topic>Psychopathology</topic><topic>Regular Articles</topic><topic>Self Report</topic><topic>Serotonin</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Serotonin transporter</topic><topic>Small for gestational age</topic><topic>Stress</topic><topic>Survivors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lahat, Ayelet</creatorcontrib><creatorcontrib>van Lieshout, Ryan J.</creatorcontrib><creatorcontrib>Mathewson, Karen J.</creatorcontrib><creatorcontrib>Mackillop, James</creatorcontrib><creatorcontrib>Saigal, Saroj</creatorcontrib><creatorcontrib>Morrison, Katherine M.</creatorcontrib><creatorcontrib>Boyle, Michael H.</creatorcontrib><creatorcontrib>Schmidt, Louis A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Criminal Justice Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Development and psychopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lahat, Ayelet</au><au>van Lieshout, Ryan J.</au><au>Mathewson, Karen J.</au><au>Mackillop, James</au><au>Saigal, Saroj</au><au>Morrison, Katherine M.</au><au>Boyle, Michael H.</au><au>Schmidt, Louis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life</atitle><jtitle>Development and psychopathology</jtitle><addtitle>Dev Psychopathol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>29</volume><issue>3</issue><spage>837</spage><epage>843</epage><pages>837-843</pages><issn>0954-5794</issn><eissn>1469-2198</eissn><abstract>Extremely low birth weight (ELBW; <1000 g) infants have been exposed to stressful intrauterine and early postnatal environments. Even greater early adversity has been experienced by ELBW survivors who were also born small for gestational age (SGA; <10th percentile for GA) compared to those born appropriate for GA (AGA). ELBW survivors, particularly those born SGA, face increased risk for internalizing problems compared to normal BW (NBW; ≥2500 g) controls. Internalizing problems are related to allelic variations in the promoter region of the serotonin transporter linked polymorphic region gene (5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>27416920</pmid><doi>10.1017/S0954579416000511</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0954-5794 |
| ispartof | Development and psychopathology, 2017-08, Vol.29 (3), p.837-843 |
| issn | 0954-5794 1469-2198 |
| language | eng |
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| source | MEDLINE; Cambridge Journals |
| subjects | Adult Adults Age Anxiety Attention deficit hyperactivity disorder Babies Birth weight Dental Anxiety - etiology Depression - etiology Female Gene-Environment Interaction Gestational age Humans Infant, Extremely Low Birth Weight Infant, Newborn Infants Intensive care Intrauterine exposure Low birth weight Male Mental depression Pediatrics Psychiatry Psychopathology Regular Articles Self Report Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin transporter Small for gestational age Stress Survivors Young Adult |
| title | Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life |
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