Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels
Objectives To evaluate whether cerebrospinal fluid (CSF) and PET Pittsburgh Compound B (PiB) biomarkers of underlying Alzheimer disease (AD) pathology (β-amyloid42 [Aβ42 ], tau, phosphorylated tau181 [ptau181 ], tau/Aβ42 , ptau181 /Aβ42 and mean cortical binding potential [MCBP] for PET-PiB) predict...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2016-11, Vol.24 (11), p.1095-1104 |
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| creator | Babulal, Ganesh M., O.T.D Ghoshal, Nupur, M.D., Ph.D Head, Denise, Ph.D Vernon, Elizabeth K., B.A Holtzman, David M., M.D Benzinger, Tammie L.S., M.D., Ph.D Fagan, Anne M., Ph.D Morris, John C., M.D Roe, Catherine M., Ph.D |
| description | Objectives To evaluate whether cerebrospinal fluid (CSF) and PET Pittsburgh Compound B (PiB) biomarkers of underlying Alzheimer disease (AD) pathology (β-amyloid42 [Aβ42 ], tau, phosphorylated tau181 [ptau181 ], tau/Aβ42 , ptau181 /Aβ42 and mean cortical binding potential [MCBP] for PET-PiB) predict changes in mood in cognitively normal older adults. Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC. Measurements CSF, PET-PiB biomarkers, Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Profile of Mood States-Short Form (POMS-SF), the Geriatric Depression Scale (GDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Data from 118 participants at baseline and 66 participants at one-year follow-up were analyzed. CSF and PET biomarkers were not associated cross-sectionally with any mood disturbances at baseline (p > 0.05). Changes in mood as indicated by the total mood disturbance score on the POMS-SF, selected POMS-SF subscales, GDS, and NPI-Q scores from baseline to one-year follow-up were associated with (p |
| doi_str_mv | 10.1016/j.jagp.2016.04.004 |
| format | Article |
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Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC. Measurements CSF, PET-PiB biomarkers, Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Profile of Mood States-Short Form (POMS-SF), the Geriatric Depression Scale (GDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Data from 118 participants at baseline and 66 participants at one-year follow-up were analyzed. CSF and PET biomarkers were not associated cross-sectionally with any mood disturbances at baseline (p > 0.05). Changes in mood as indicated by the total mood disturbance score on the POMS-SF, selected POMS-SF subscales, GDS, and NPI-Q scores from baseline to one-year follow-up were associated with (p < 0.05) CSF and PET-PiB biomarkers. There was no statistically significant decline in cognitive functioning. Conclusions Generally, higher values of CSF and PET-PiB biomarkers are associated with more changes in mood in cognitively normal older adults. Further work is needed to understand the temporal development of mood changes over several years during the phase of preclinical AD. Evaluating mood as a noncognitive outcome may provide further insight into the development of preclinical AD in cognitively normal older adults.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1016/j.jagp.2016.04.004</identifier><identifier>PMID: 27426238</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Alzheimer disease ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Amyloid beta-Peptides - cerebrospinal fluid ; Aniline Compounds - metabolism ; biomarkers ; Biomarkers - metabolism ; Brain - diagnostic imaging ; Brain - metabolism ; depression ; Depression - diagnostic imaging ; Depression - metabolism ; Depressive Disorder - diagnostic imaging ; Depressive Disorder - metabolism ; Female ; Humans ; Internal Medicine ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; mood ; Mood Disorders - diagnostic imaging ; Mood Disorders - metabolism ; older adults ; Peptide Fragments - cerebrospinal fluid ; Phosphoproteins - cerebrospinal fluid ; Positron-Emission Tomography ; tau Proteins - cerebrospinal fluid ; Thiazoles - metabolism</subject><ispartof>The American journal of geriatric psychiatry, 2016-11, Vol.24 (11), p.1095-1104</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2016 American Association for Geriatric Psychiatry</rights><rights>Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-9c083ace7adf951f814c1b1d7f71260e152e9ca3df28ca3993046c378a73a4ff3</citedby><cites>FETCH-LOGICAL-c455t-9c083ace7adf951f814c1b1d7f71260e152e9ca3df28ca3993046c378a73a4ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27426238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babulal, Ganesh M., O.T.D</creatorcontrib><creatorcontrib>Ghoshal, Nupur, M.D., Ph.D</creatorcontrib><creatorcontrib>Head, Denise, Ph.D</creatorcontrib><creatorcontrib>Vernon, Elizabeth K., B.A</creatorcontrib><creatorcontrib>Holtzman, David M., M.D</creatorcontrib><creatorcontrib>Benzinger, Tammie L.S., M.D., Ph.D</creatorcontrib><creatorcontrib>Fagan, Anne M., Ph.D</creatorcontrib><creatorcontrib>Morris, John C., M.D</creatorcontrib><creatorcontrib>Roe, Catherine M., Ph.D</creatorcontrib><title>Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Objectives To evaluate whether cerebrospinal fluid (CSF) and PET Pittsburgh Compound B (PiB) biomarkers of underlying Alzheimer disease (AD) pathology (β-amyloid42 [Aβ42 ], tau, phosphorylated tau181 [ptau181 ], tau/Aβ42 , ptau181 /Aβ42 and mean cortical binding potential [MCBP] for PET-PiB) predict changes in mood in cognitively normal older adults. Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC. Measurements CSF, PET-PiB biomarkers, Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Profile of Mood States-Short Form (POMS-SF), the Geriatric Depression Scale (GDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Data from 118 participants at baseline and 66 participants at one-year follow-up were analyzed. CSF and PET biomarkers were not associated cross-sectionally with any mood disturbances at baseline (p > 0.05). Changes in mood as indicated by the total mood disturbance score on the POMS-SF, selected POMS-SF subscales, GDS, and NPI-Q scores from baseline to one-year follow-up were associated with (p < 0.05) CSF and PET-PiB biomarkers. There was no statistically significant decline in cognitive functioning. Conclusions Generally, higher values of CSF and PET-PiB biomarkers are associated with more changes in mood in cognitively normal older adults. Further work is needed to understand the temporal development of mood changes over several years during the phase of preclinical AD. Evaluating mood as a noncognitive outcome may provide further insight into the development of preclinical AD in cognitively normal older adults.</description><subject>Aged</subject><subject>Alzheimer disease</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Amyloid beta-Peptides - cerebrospinal fluid</subject><subject>Aniline Compounds - metabolism</subject><subject>biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>depression</subject><subject>Depression - diagnostic imaging</subject><subject>Depression - metabolism</subject><subject>Depressive Disorder - diagnostic imaging</subject><subject>Depressive Disorder - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>mood</subject><subject>Mood Disorders - diagnostic imaging</subject><subject>Mood Disorders - metabolism</subject><subject>older adults</subject><subject>Peptide Fragments - cerebrospinal fluid</subject><subject>Phosphoproteins - cerebrospinal fluid</subject><subject>Positron-Emission Tomography</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>Thiazoles - metabolism</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS1ERUvhC3BAPnJJ8L8kjoSQloWWSgs9AGfj2pOts068tZNKy6fH0bY9cOA0o5n3nuzfIPSGkpISWr_vy15v9yXLfUlESYh4hs5oJaqiYVQ8zz2pRdEISU_Ry5R6Qkjd1uIFOmWNYDXj8gz9_haCxetbPW4hYTfiddiObnL34A_4e4iD9vjaW4h4ZWc_Jawj4I0bd2DxFPDK_7kFN-T1Z5dAJ8CfXBh03OXJBnJIeoVOOu0TvH6o5-jXxZef66_F5vryar3aFEZU1VS0hkiuDTTadm1FO0mFoTfUNl1DWU2AVgxao7ntmMylbTkRteGN1A3Xouv4OXp3zN3HcDdDmtTgkgHv9QhhTopKVjeMSUmzlB2lJoaUInRqH11-9EFRohayqlcLWbWQVUSoTDab3j7kzzcD2CfLI8os-HAU5E_DvYOoknEwGrAugpmUDe7_-R__sRvvRme038EBUh_mOGZ-iqrEFFE_ltsup6U1J0Qyzv8CFJSeeg</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Babulal, Ganesh M., O.T.D</creator><creator>Ghoshal, Nupur, M.D., Ph.D</creator><creator>Head, Denise, Ph.D</creator><creator>Vernon, Elizabeth K., B.A</creator><creator>Holtzman, David M., M.D</creator><creator>Benzinger, Tammie L.S., M.D., Ph.D</creator><creator>Fagan, Anne M., Ph.D</creator><creator>Morris, John C., M.D</creator><creator>Roe, Catherine M., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels</title><author>Babulal, Ganesh M., O.T.D ; Ghoshal, Nupur, M.D., Ph.D ; Head, Denise, Ph.D ; Vernon, Elizabeth K., B.A ; Holtzman, David M., M.D ; Benzinger, Tammie L.S., M.D., Ph.D ; Fagan, Anne M., Ph.D ; Morris, John C., M.D ; Roe, Catherine M., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-9c083ace7adf951f814c1b1d7f71260e152e9ca3df28ca3993046c378a73a4ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Alzheimer disease</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - metabolism</topic><topic>Amyloid beta-Peptides - cerebrospinal fluid</topic><topic>Aniline Compounds - metabolism</topic><topic>biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>depression</topic><topic>Depression - diagnostic imaging</topic><topic>Depression - metabolism</topic><topic>Depressive Disorder - diagnostic imaging</topic><topic>Depressive Disorder - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>mood</topic><topic>Mood Disorders - diagnostic imaging</topic><topic>Mood Disorders - metabolism</topic><topic>older adults</topic><topic>Peptide Fragments - cerebrospinal fluid</topic><topic>Phosphoproteins - cerebrospinal fluid</topic><topic>Positron-Emission Tomography</topic><topic>tau Proteins - cerebrospinal fluid</topic><topic>Thiazoles - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babulal, Ganesh M., O.T.D</creatorcontrib><creatorcontrib>Ghoshal, Nupur, M.D., Ph.D</creatorcontrib><creatorcontrib>Head, Denise, Ph.D</creatorcontrib><creatorcontrib>Vernon, Elizabeth K., B.A</creatorcontrib><creatorcontrib>Holtzman, David M., M.D</creatorcontrib><creatorcontrib>Benzinger, Tammie L.S., M.D., Ph.D</creatorcontrib><creatorcontrib>Fagan, Anne M., Ph.D</creatorcontrib><creatorcontrib>Morris, John C., M.D</creatorcontrib><creatorcontrib>Roe, Catherine M., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babulal, Ganesh M., O.T.D</au><au>Ghoshal, Nupur, M.D., Ph.D</au><au>Head, Denise, Ph.D</au><au>Vernon, Elizabeth K., B.A</au><au>Holtzman, David M., M.D</au><au>Benzinger, Tammie L.S., M.D., Ph.D</au><au>Fagan, Anne M., Ph.D</au><au>Morris, John C., M.D</au><au>Roe, Catherine M., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>24</volume><issue>11</issue><spage>1095</spage><epage>1104</epage><pages>1095-1104</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Objectives To evaluate whether cerebrospinal fluid (CSF) and PET Pittsburgh Compound B (PiB) biomarkers of underlying Alzheimer disease (AD) pathology (β-amyloid42 [Aβ42 ], tau, phosphorylated tau181 [ptau181 ], tau/Aβ42 , ptau181 /Aβ42 and mean cortical binding potential [MCBP] for PET-PiB) predict changes in mood in cognitively normal older adults. Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC. Measurements CSF, PET-PiB biomarkers, Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Profile of Mood States-Short Form (POMS-SF), the Geriatric Depression Scale (GDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Data from 118 participants at baseline and 66 participants at one-year follow-up were analyzed. CSF and PET biomarkers were not associated cross-sectionally with any mood disturbances at baseline (p > 0.05). Changes in mood as indicated by the total mood disturbance score on the POMS-SF, selected POMS-SF subscales, GDS, and NPI-Q scores from baseline to one-year follow-up were associated with (p < 0.05) CSF and PET-PiB biomarkers. There was no statistically significant decline in cognitive functioning. Conclusions Generally, higher values of CSF and PET-PiB biomarkers are associated with more changes in mood in cognitively normal older adults. Further work is needed to understand the temporal development of mood changes over several years during the phase of preclinical AD. Evaluating mood as a noncognitive outcome may provide further insight into the development of preclinical AD in cognitively normal older adults.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>27426238</pmid><doi>10.1016/j.jagp.2016.04.004</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alzheimer disease Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Amyloid beta-Peptides - cerebrospinal fluid Aniline Compounds - metabolism biomarkers Biomarkers - metabolism Brain - diagnostic imaging Brain - metabolism depression Depression - diagnostic imaging Depression - metabolism Depressive Disorder - diagnostic imaging Depressive Disorder - metabolism Female Humans Internal Medicine Longitudinal Studies Magnetic Resonance Imaging Male mood Mood Disorders - diagnostic imaging Mood Disorders - metabolism older adults Peptide Fragments - cerebrospinal fluid Phosphoproteins - cerebrospinal fluid Positron-Emission Tomography tau Proteins - cerebrospinal fluid Thiazoles - metabolism |
| title | Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels |
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