Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells

Pogostemon cablin is a medicinal herb widely used to treat gastrointestinal diseases in many Asian countries. Pogostone is an important constituent of Pogostemon cablin, and possesses various bioactivitys. In this study, we performed to investigate the anti-colorectal tumor property of Pogostone by...

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Veröffentlicht in:	Journal of ethnopharmacology 2017-04, Vol.202, p.20-27
Hauptverfasser:	Cao, Zhi-Xing, Yang, Yu-Ting, Yu, Si, Li, Yu-Zhi, Wang, Wen-Wen, Huang, Jing, Xie, Xiao-Fang, Xiong, Liang, Lei, Song, Peng, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Cell Survival - drug effects Colorectal Neoplasms Female HCT116 Cells Humans Mice Mice, Inbred BALB C Mice, Nude mTOR Oils, Volatile - pharmacology Oncogene Protein v-akt - drug effects Phosphatidylinositol 3-Kinases - drug effects Pogostone Signal Transduction - drug effects TOR Serine-Threonine Kinases - drug effects Xenograft Model Antitumor Assays
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