Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non‐alcoholic steatohepatitis, modified choline‐deficient, amino acid‐defined diet fed low‐density lipoprotein receptor knockout mice

Aim Low‐density lipoprotein receptor knockout (LDLR‐KO) mice fed a modified choline‐deficient and amino acid‐defined (mCDAA) diet show non‐alcoholic steatohepatitis (NASH)‐like pathophysiology. In order to pharmacologically benchmark this model, effects of pioglitazone (a thiazolidinedione) and cand...

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Veröffentlicht in:	Hepatology research 2017-05, Vol.47 (6), p.584-592
Hauptverfasser:	Tsuchiya, Shuntarou, Amano, Yuichiro, Isono, Osamu, Imai, Mayumi, Shimizu, Fumi, Asada, Mari, Imai, Shigemitsu, Harada, Ayako, Yasuhara, Yoshitaka, Tozawa, Ryuichi, Nagabukuro, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Amino acids Angiotensin Angiotensin II Candesartan cilexetil Choline Collagen (type I) Fatty liver Fibrosis Gene expression hepatic fibrosis Interleukin 6 LDL receptor knockout mouse Liver Low density lipoprotein receptors non‐alcoholic steatohepatitis Pioglitazone Receptor density Rodents Steatosis Tissue inhibitor of metalloproteinase 1 Transaminase Transforming growth factor-b1
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