TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles

ABSTRACT Innate immune reactions to orthopedic implant debris are the primary cause of total joint replacement (TJR) failure over the long term (15–20 years). The role of pathogen associated pattern recognition receptors (i.e., TLRs) in regulating immune reactivity to metal implant particles remains...

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Veröffentlicht in:	Journal of orthopaedic research 2017-05, Vol.35 (5), p.1007-1017
Hauptverfasser:	Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone Cell Line implant wear infection inflammation Interleukin-1beta - secretion Lipopeptides Lipopolysaccharides Male Metals, Heavy - adverse effects Metals, Heavy - immunology Mice, Inbred C57BL Monocytes - metabolism Osteolysis - etiology osteolysis and adverse soft tissue reaction Prostheses and Implants - adverse effects synovium & osteoarthritis Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - secretion
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