Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer
Background Colorectal cancer (CRC) is the third leading cause of death from cancer worldwide. Immature colon carcinoma transcript-1 (ICT1) has been reported to be correlated with lung cancer; however, whether ICT1 is a functional gene in CRC, as well as the molecular mechanism underlying ICT1 mediat...
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| Veröffentlicht in: | Annals of surgical oncology 2016-11, Vol.23 (12), p.3924-3933 |
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| container_title | Annals of surgical oncology |
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| creator | Lao, Xinyuan Feng, Qingyang He, Guodong Ji, Meiling Zhu, Dexiang Xu, Pingping Tang, Wentao Xu, Jianmin Qin, Xinyu |
| description | Background
Colorectal cancer (CRC) is the third leading cause of death from cancer worldwide. Immature colon carcinoma transcript-1 (ICT1) has been reported to be correlated with lung cancer; however, whether ICT1 is a functional gene in CRC, as well as the molecular mechanism underlying ICT1 mediation of colorectal-tumor formation, remains unknown.
Methods
The expression of ICT1 was firstly determined by using immunohistochemistry in 861 CRC specimens. The correlation of ICT1 expression with clinicopathological parameters and the survival rate was analyzed. Furthermore, we investigated the effect of ICT1 silencing on CRC cell proliferation and migration by MTT, colony formation, flow cytometry, and transwell in vitro.
Results
ICT1 is highly expressed in a cohort of human CRCs, and that higher ICT1 expression may lead to reduced overall survival rate of CRC. Likewise, ICT1 silencing lowered the cell viability through cell-cycle arrest, inhibited cell migration, and induced apoptosis in CRC. We further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways.
Conclusions
Our data showed that ICT1 could be an important target for CRC diagnosis and treatment. |
| doi_str_mv | 10.1245/s10434-016-5305-1 |
| format | Article |
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Colorectal cancer (CRC) is the third leading cause of death from cancer worldwide. Immature colon carcinoma transcript-1 (ICT1) has been reported to be correlated with lung cancer; however, whether ICT1 is a functional gene in CRC, as well as the molecular mechanism underlying ICT1 mediation of colorectal-tumor formation, remains unknown.
Methods
The expression of ICT1 was firstly determined by using immunohistochemistry in 861 CRC specimens. The correlation of ICT1 expression with clinicopathological parameters and the survival rate was analyzed. Furthermore, we investigated the effect of ICT1 silencing on CRC cell proliferation and migration by MTT, colony formation, flow cytometry, and transwell in vitro.
Results
ICT1 is highly expressed in a cohort of human CRCs, and that higher ICT1 expression may lead to reduced overall survival rate of CRC. Likewise, ICT1 silencing lowered the cell viability through cell-cycle arrest, inhibited cell migration, and induced apoptosis in CRC. We further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways.
Conclusions
Our data showed that ICT1 could be an important target for CRC diagnosis and treatment.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-016-5305-1</identifier><identifier>PMID: 27411551</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adenylate Kinase - metabolism ; Aged ; Apoptosis - genetics ; Carcinoma - genetics ; Carcinoma - metabolism ; Carcinoma - secondary ; Cell Movement - genetics ; Cell Proliferation - genetics ; Cell Survival - genetics ; Colorectal Cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Female ; G2 Phase Cell Cycle Checkpoints - genetics ; Gene Silencing ; HCT116 Cells ; Humans ; Male ; MAP Kinase Signaling System ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Poly(ADP-ribose) Polymerases - metabolism ; Prognosis ; Proteins - genetics ; Proteins - metabolism ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2016-11, Vol.23 (12), p.3924-3933</ispartof><rights>Society of Surgical Oncology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9b0286716ee643faeef0c8ac15e4dbc5344c66b91eec3eadfa7aeaff927fb52c3</citedby><cites>FETCH-LOGICAL-c372t-9b0286716ee643faeef0c8ac15e4dbc5344c66b91eec3eadfa7aeaff927fb52c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-016-5305-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-016-5305-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27411551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lao, Xinyuan</creatorcontrib><creatorcontrib>Feng, Qingyang</creatorcontrib><creatorcontrib>He, Guodong</creatorcontrib><creatorcontrib>Ji, Meiling</creatorcontrib><creatorcontrib>Zhu, Dexiang</creatorcontrib><creatorcontrib>Xu, Pingping</creatorcontrib><creatorcontrib>Tang, Wentao</creatorcontrib><creatorcontrib>Xu, Jianmin</creatorcontrib><creatorcontrib>Qin, Xinyu</creatorcontrib><title>Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Colorectal cancer (CRC) is the third leading cause of death from cancer worldwide. Immature colon carcinoma transcript-1 (ICT1) has been reported to be correlated with lung cancer; however, whether ICT1 is a functional gene in CRC, as well as the molecular mechanism underlying ICT1 mediation of colorectal-tumor formation, remains unknown.
Methods
The expression of ICT1 was firstly determined by using immunohistochemistry in 861 CRC specimens. The correlation of ICT1 expression with clinicopathological parameters and the survival rate was analyzed. Furthermore, we investigated the effect of ICT1 silencing on CRC cell proliferation and migration by MTT, colony formation, flow cytometry, and transwell in vitro.
Results
ICT1 is highly expressed in a cohort of human CRCs, and that higher ICT1 expression may lead to reduced overall survival rate of CRC. Likewise, ICT1 silencing lowered the cell viability through cell-cycle arrest, inhibited cell migration, and induced apoptosis in CRC. We further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways.
Conclusions
Our data showed that ICT1 could be an important target for CRC diagnosis and treatment.</description><subject>Adenylate Kinase - metabolism</subject><subject>Aged</subject><subject>Apoptosis - genetics</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - secondary</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Cell Survival - genetics</subject><subject>Colorectal Cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>G2 Phase Cell Cycle Checkpoints - genetics</subject><subject>Gene Silencing</subject><subject>HCT116 Cells</subject><subject>Humans</subject><subject>Male</subject><subject>MAP Kinase Signaling System</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Prognosis</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcFu1DAQhiMEoqXwAFyQJS7lEPA4sZMcUVRgpUpUYnuOJt5JcZXYyzjZwkPwzjjaBSEkTh55vv-f0fxZ9hLkW1ClfhdBlkWZSzC5LqTO4VF2Djr9lKaGx6mWps4bZfRZ9izGeymhStjT7ExVJYDWcJ793EwTzguTaMMYvGiRrfNhQrFl9NGy2885iMtNu4U34ur7nilGt4KBmUacKYoHN38Vt37AQ2DsRxI3HO58iC4K9DvxZeGDO-AonBc3ODvy80mzjmSyc-q16C3x8-zJgGOkF6f3Irv9cLVtP-XXnz9u2vfXuS0qNedNL1VtKjBEpiwGJBqkrdGCpnLX23SB0hrTN0BkC8LdgBUSDkOjqqHXyhYX2eXRd8_h20Jx7iYXLY0jegpL7KBWyb6qdJPQ1_-g92Fhn7ZbKV0YLVWRKDhSlkOMTEO3Zzch_-hAdmtW3TGrLmXVrVl1kDSvTs5LP9Huj-J3OAlQRyCmlr8j_mv0f11_AaB5oRg</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Lao, Xinyuan</creator><creator>Feng, Qingyang</creator><creator>He, Guodong</creator><creator>Ji, Meiling</creator><creator>Zhu, Dexiang</creator><creator>Xu, Pingping</creator><creator>Tang, Wentao</creator><creator>Xu, Jianmin</creator><creator>Qin, Xinyu</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer</title><author>Lao, Xinyuan ; 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Colorectal cancer (CRC) is the third leading cause of death from cancer worldwide. Immature colon carcinoma transcript-1 (ICT1) has been reported to be correlated with lung cancer; however, whether ICT1 is a functional gene in CRC, as well as the molecular mechanism underlying ICT1 mediation of colorectal-tumor formation, remains unknown.
Methods
The expression of ICT1 was firstly determined by using immunohistochemistry in 861 CRC specimens. The correlation of ICT1 expression with clinicopathological parameters and the survival rate was analyzed. Furthermore, we investigated the effect of ICT1 silencing on CRC cell proliferation and migration by MTT, colony formation, flow cytometry, and transwell in vitro.
Results
ICT1 is highly expressed in a cohort of human CRCs, and that higher ICT1 expression may lead to reduced overall survival rate of CRC. Likewise, ICT1 silencing lowered the cell viability through cell-cycle arrest, inhibited cell migration, and induced apoptosis in CRC. We further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways.
Conclusions
Our data showed that ICT1 could be an important target for CRC diagnosis and treatment.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27411551</pmid><doi>10.1245/s10434-016-5305-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2016-11, Vol.23 (12), p.3924-3933 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenylate Kinase - metabolism Aged Apoptosis - genetics Carcinoma - genetics Carcinoma - metabolism Carcinoma - secondary Cell Movement - genetics Cell Proliferation - genetics Cell Survival - genetics Colorectal Cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female G2 Phase Cell Cycle Checkpoints - genetics Gene Silencing HCT116 Cells Humans Male MAP Kinase Signaling System Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Staging Oncology Poly(ADP-ribose) Polymerases - metabolism Prognosis Proteins - genetics Proteins - metabolism Surgery Surgical Oncology Survival Rate |
| title | Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer |
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