Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis

[Display omitted] This study reports a promising approach to enhance the oral delivery of propolis, improve its aqueous solubility and bioavailability, and allow its controlled release as well as enhancing its anticancer activity. Propolis was standardized then its solubility was improved via formul...

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Veröffentlicht in:	International journal of biological macromolecules 2016-11, Vol.92, p.254-269
Hauptverfasser:	Elbaz, Nancy M., Khalil, Islam A., Abd-Rabou, Ahmed A., El-Sherbiny, Ibrahim M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Calorimetry, Differential Scanning Cell Cycle Checkpoints Chitosan - chemistry Chromatography, High Pressure Liquid Colon cancer Drug Carriers - chemistry Drug Delivery Systems - methods Drug Liberation HCT116 Cells Hep G2 Cells Humans Liver cancer Microspheres Mitochondria - drug effects Mitochondria - metabolism Nano-in-Microparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Oral delivery Phenols - analysis PLGA Pluronic F-108 Propolis Propolis - pharmacokinetics Propolis - pharmacology Reference Standards Solid dispersion Solubility Spectroscopy, Fourier Transform Infrared Staining and Labeling
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