Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy
Background/aimsTo investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).MethodsSwept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively...
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| Veröffentlicht in: | British journal of ophthalmology 2017-04, Vol.101 (4), p.433-437 |
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| container_title | British journal of ophthalmology |
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| creator | Izumi, Takahiko Koizumi, Hideki Maruko, Ichiro Takahashi, Yohei Sonoda, Shozo Sakamoto, Taiji Iida, Tomohiro |
| description | Background/aimsTo investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).MethodsSwept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively analysed by a manual delineation technique and binarisation method.ResultsIn the 22 eyes, the mean subfoveal choroidal thickness decreased from 412.9±112.9 μm at baseline to 340.0±111.0 μm at 3 months (p |
| doi_str_mv | 10.1136/bjophthalmol-2016-308921 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826716177</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321358783</sourcerecordid><originalsourceid>FETCH-LOGICAL-b387t-d80a158b088e6ee4255554485fbead2bc564d607834138ac7153276d53af8bac3</originalsourceid><addsrcrecordid>eNqNkUtr3TAQRkVoaG6S_oUg6KYbp3rY0txlCc0DAlk0WRtZHmFfbMuV5IL_feXctJSuoo2QOPPNMIcQytk151J9bQ5-7lJnhtEPhWBcFZLBXvATsuOlgvyl9x_IjjGmC84VPyPnMR7yUyiuP5IzoSWAKGFH0o8UFpuWYAZqJjOsESP1jtrOB9-31LiEgeZOrmh9RPoLQ8LZB9dPdO588u06mbG3NHUYzLxS5wO1OKUtMGLwS3zN6n3A1E9-NqlbL8mpM0PET2_3BXm5_f58c188Pt093Hx7LBoJOhUtMMMraBgAKsRSVPmUJVSuQdOKxlaqbBXTIEsuwVjNKym0aitpHDTGygvy5Zg7B_9zwZjqsY8Wh8FMmAerOQil83q0zujn_9CDX0JeyEaB2HMGfKPgSNngYwzo6jn0owlrzVm9man_NVNvZuqjmVx69dZgaUZs_xb-UZEBeQSa8fD-2N9HQKEI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1882910817</pqid></control><display><type>article</type><title>Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy</title><source>MEDLINE</source><source>PubMed Central</source><creator>Izumi, Takahiko ; Koizumi, Hideki ; Maruko, Ichiro ; Takahashi, Yohei ; Sonoda, Shozo ; Sakamoto, Taiji ; Iida, Tomohiro</creator><creatorcontrib>Izumi, Takahiko ; Koizumi, Hideki ; Maruko, Ichiro ; Takahashi, Yohei ; Sonoda, Shozo ; Sakamoto, Taiji ; Iida, Tomohiro</creatorcontrib><description>Background/aimsTo investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).MethodsSwept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively analysed by a manual delineation technique and binarisation method.ResultsIn the 22 eyes, the mean subfoveal choroidal thickness decreased from 412.9±112.9 μm at baseline to 340.0±111.0 μm at 3 months (p<0.0001). The mean thickness of the large choroidal vessel layer decreased from 368.7±112.7 μm at baseline to 292.2±118.0 μm at 3 months (p<0.0001), but the mean choriocapillaris-medium choroidal vessel layer thickness did not change from 44.2±29.2 μm at baseline to 47.8±25.7 μm at 3 months (p=0.85). Analyses of the binarised choroidal images showed that a 3 mm subfoveal choroidal area decreased from 1.141±0.290 mm2 at baseline to 0.962±0.320 mm2 at 3 months after PDT (p=0.0001). The mean luminal areas decreased from 0.826±0.246 mm2 at baseline to 0.665±0.234 mm2 at 3 months (p=0.0001), however, the mean stromal areas did not change from 0.315±0.066 mm2 at baseline to 0.297±0.095 mm2 at 3 months (p=0.60).ConclusionsHalf-dose PDT reduces subfoveal choroidal thickness and alters the intrachoroidal structures in eyes with CSC.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2016-308921</identifier><identifier>PMID: 27388248</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Central Serous Chorioretinopathy - diagnostic imaging ; Central Serous Chorioretinopathy - drug therapy ; Central Serous Chorioretinopathy - physiopathology ; Choroid - diagnostic imaging ; Choroid - drug effects ; Choroid - pathology ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents - therapeutic use ; Porphyrins - therapeutic use ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2017-04, Vol.101 (4), p.433-437</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</rights><rights>Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b387t-d80a158b088e6ee4255554485fbead2bc564d607834138ac7153276d53af8bac3</citedby><cites>FETCH-LOGICAL-b387t-d80a158b088e6ee4255554485fbead2bc564d607834138ac7153276d53af8bac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27388248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izumi, Takahiko</creatorcontrib><creatorcontrib>Koizumi, Hideki</creatorcontrib><creatorcontrib>Maruko, Ichiro</creatorcontrib><creatorcontrib>Takahashi, Yohei</creatorcontrib><creatorcontrib>Sonoda, Shozo</creatorcontrib><creatorcontrib>Sakamoto, Taiji</creatorcontrib><creatorcontrib>Iida, Tomohiro</creatorcontrib><title>Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Background/aimsTo investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).MethodsSwept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively analysed by a manual delineation technique and binarisation method.ResultsIn the 22 eyes, the mean subfoveal choroidal thickness decreased from 412.9±112.9 μm at baseline to 340.0±111.0 μm at 3 months (p<0.0001). The mean thickness of the large choroidal vessel layer decreased from 368.7±112.7 μm at baseline to 292.2±118.0 μm at 3 months (p<0.0001), but the mean choriocapillaris-medium choroidal vessel layer thickness did not change from 44.2±29.2 μm at baseline to 47.8±25.7 μm at 3 months (p=0.85). Analyses of the binarised choroidal images showed that a 3 mm subfoveal choroidal area decreased from 1.141±0.290 mm2 at baseline to 0.962±0.320 mm2 at 3 months after PDT (p=0.0001). The mean luminal areas decreased from 0.826±0.246 mm2 at baseline to 0.665±0.234 mm2 at 3 months (p=0.0001), however, the mean stromal areas did not change from 0.315±0.066 mm2 at baseline to 0.297±0.095 mm2 at 3 months (p=0.60).ConclusionsHalf-dose PDT reduces subfoveal choroidal thickness and alters the intrachoroidal structures in eyes with CSC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Central Serous Chorioretinopathy - diagnostic imaging</subject><subject>Central Serous Chorioretinopathy - drug therapy</subject><subject>Central Serous Chorioretinopathy - physiopathology</subject><subject>Choroid - diagnostic imaging</subject><subject>Choroid - drug effects</subject><subject>Choroid - pathology</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Porphyrins - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtr3TAQRkVoaG6S_oUg6KYbp3rY0txlCc0DAlk0WRtZHmFfbMuV5IL_feXctJSuoo2QOPPNMIcQytk151J9bQ5-7lJnhtEPhWBcFZLBXvATsuOlgvyl9x_IjjGmC84VPyPnMR7yUyiuP5IzoSWAKGFH0o8UFpuWYAZqJjOsESP1jtrOB9-31LiEgeZOrmh9RPoLQ8LZB9dPdO588u06mbG3NHUYzLxS5wO1OKUtMGLwS3zN6n3A1E9-NqlbL8mpM0PET2_3BXm5_f58c188Pt093Hx7LBoJOhUtMMMraBgAKsRSVPmUJVSuQdOKxlaqbBXTIEsuwVjNKym0aitpHDTGygvy5Zg7B_9zwZjqsY8Wh8FMmAerOQil83q0zujn_9CDX0JeyEaB2HMGfKPgSNngYwzo6jn0owlrzVm9man_NVNvZuqjmVx69dZgaUZs_xb-UZEBeQSa8fD-2N9HQKEI</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Izumi, Takahiko</creator><creator>Koizumi, Hideki</creator><creator>Maruko, Ichiro</creator><creator>Takahashi, Yohei</creator><creator>Sonoda, Shozo</creator><creator>Sakamoto, Taiji</creator><creator>Iida, Tomohiro</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy</title><author>Izumi, Takahiko ; Koizumi, Hideki ; Maruko, Ichiro ; Takahashi, Yohei ; Sonoda, Shozo ; Sakamoto, Taiji ; Iida, Tomohiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b387t-d80a158b088e6ee4255554485fbead2bc564d607834138ac7153276d53af8bac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Central Serous Chorioretinopathy - diagnostic imaging</topic><topic>Central Serous Chorioretinopathy - drug therapy</topic><topic>Central Serous Chorioretinopathy - physiopathology</topic><topic>Choroid - diagnostic imaging</topic><topic>Choroid - drug effects</topic><topic>Choroid - pathology</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Photochemotherapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Porphyrins - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izumi, Takahiko</creatorcontrib><creatorcontrib>Koizumi, Hideki</creatorcontrib><creatorcontrib>Maruko, Ichiro</creatorcontrib><creatorcontrib>Takahashi, Yohei</creatorcontrib><creatorcontrib>Sonoda, Shozo</creatorcontrib><creatorcontrib>Sakamoto, Taiji</creatorcontrib><creatorcontrib>Iida, Tomohiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Proquest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izumi, Takahiko</au><au>Koizumi, Hideki</au><au>Maruko, Ichiro</au><au>Takahashi, Yohei</au><au>Sonoda, Shozo</au><au>Sakamoto, Taiji</au><au>Iida, Tomohiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2017-04</date><risdate>2017</risdate><volume>101</volume><issue>4</issue><spage>433</spage><epage>437</epage><pages>433-437</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Background/aimsTo investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).MethodsSwept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively analysed by a manual delineation technique and binarisation method.ResultsIn the 22 eyes, the mean subfoveal choroidal thickness decreased from 412.9±112.9 μm at baseline to 340.0±111.0 μm at 3 months (p<0.0001). The mean thickness of the large choroidal vessel layer decreased from 368.7±112.7 μm at baseline to 292.2±118.0 μm at 3 months (p<0.0001), but the mean choriocapillaris-medium choroidal vessel layer thickness did not change from 44.2±29.2 μm at baseline to 47.8±25.7 μm at 3 months (p=0.85). Analyses of the binarised choroidal images showed that a 3 mm subfoveal choroidal area decreased from 1.141±0.290 mm2 at baseline to 0.962±0.320 mm2 at 3 months after PDT (p=0.0001). The mean luminal areas decreased from 0.826±0.246 mm2 at baseline to 0.665±0.234 mm2 at 3 months (p=0.0001), however, the mean stromal areas did not change from 0.315±0.066 mm2 at baseline to 0.297±0.095 mm2 at 3 months (p=0.60).ConclusionsHalf-dose PDT reduces subfoveal choroidal thickness and alters the intrachoroidal structures in eyes with CSC.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>27388248</pmid><doi>10.1136/bjophthalmol-2016-308921</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Central Serous Chorioretinopathy - diagnostic imaging Central Serous Chorioretinopathy - drug therapy Central Serous Chorioretinopathy - physiopathology Choroid - diagnostic imaging Choroid - drug effects Choroid - pathology Female Fluorescein Angiography Follow-Up Studies Humans Male Middle Aged Photochemotherapy Photosensitizing Agents - therapeutic use Porphyrins - therapeutic use Retrospective Studies Tomography, Optical Coherence Treatment Outcome Visual Acuity |
| title | Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy |
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