In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio

Nowadays, combination therapy became a standard in oncology. In this study, we compare the activity of two polymeric carriers bearing a combination of the anticancer drugs paclitaxel (PTX) and doxorubicin (DOX), which differ mainly in their architecture and supramolecular assembly. Drugs were covale...

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Veröffentlicht in:	Journal of controlled release 2017-07, Vol.257, p.118-131
Hauptverfasser:	Baabur-Cohen, Hemda, Vossen, Laura Isabel, Krüger, Harald Rune, Eldar-boock, Anat, Yeini, Eilam, Landa-Rouben, Natalie, Tiram, Galia, Wedepohl, Stefanie, Markovsky, Ela, Leor, Jonathan, Calderón, Marcelo, Satchi-Fainaro, Ronit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Cell Line, Tumor Cell Survival - drug effects Combination therapy Dendritic polymer Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Drug Combinations Drug Delivery Systems Drug Synergism Female Glycerol - chemistry Humans Mice Mice, Inbred BALB C Paclitaxel Paclitaxel - chemistry Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Polyethylene Glycols - chemistry Polyglutamic acid Polyglutamic Acid - analogs & derivatives Polyglycerol Polymeric nanomedicines Polymers - chemistry
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