Hospitalization and mortality due to hepatitis A in Taiwan: a 15-year nationwide cohort study
Summary Hepatitis A virus (HAV) is the most common food‐borne hepatitis in the world. The study objectives were (i) to describe the epidemiology of HAV‐related hospitalizations during 1997–2011 in Taiwan, (ii) to examine the age effect on the length of stay (LOS) in hospital and (iii) to study the f...
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| Veröffentlicht in: | Journal of viral hepatitis 2016-11, Vol.23 (11), p.940-945 |
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| container_title | Journal of viral hepatitis |
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| creator | Chen, C.-M. Chen, S. C.-C. Yang, H.-Y. Yang, S.-T. Wang, C.-M. |
| description | Summary
Hepatitis A virus (HAV) is the most common food‐borne hepatitis in the world. The study objectives were (i) to describe the epidemiology of HAV‐related hospitalizations during 1997–2011 in Taiwan, (ii) to examine the age effect on the length of stay (LOS) in hospital and (iii) to study the factors associated with death. The hospitalized cases were identified from the Taiwan National Health Insurance Research Database between 1997 and 2011 by ICD‐9‐CM code of 070.0/070.1. Patient sex, birthday, dates of hospitalization and death were analysed. A total of 3990 HAV‐hospitalized cases, males 2467 (62%), were identified. The LOS increased as patients’ age increased. The overall mortality rate was 16.8 per 1000 hospitalizations. Males had significantly higher case fatality rate than females (20.7 vs 10.5 per 1000 cases). The adjusted odds ratio (aOR) for death rose by age and increased rapidly over 40 years of age. The aOR and 95% confidence interval [95%CI] for aged 40–59 years and aged over 60 years were 7.89 (1.06–58.98) and 14.88 (2.02–109.40) compared to aged 0–19 years, respectively. Patients with chronic liver disease and cirrhosis had significantly higher risk of death (aOR=1.03 [1.01–1.04]), compared to those without liver disease. However, patients with liver disease, but no cirrhosis did not have higher risk of death (aOR=1.00 [0.99–1.01]). The aOR [95%CI] for LOS >9 day was 3.26 (1.96–5.40) compared to cases with LOS ≤9 days. Male sex, age over 40 years, cirrhotic liver and long LOS are significant factors associated with death in HAV‐hospitalized cases. |
| doi_str_mv | 10.1111/jvh.12564 |
| format | Article |
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Hepatitis A virus (HAV) is the most common food‐borne hepatitis in the world. The study objectives were (i) to describe the epidemiology of HAV‐related hospitalizations during 1997–2011 in Taiwan, (ii) to examine the age effect on the length of stay (LOS) in hospital and (iii) to study the factors associated with death. The hospitalized cases were identified from the Taiwan National Health Insurance Research Database between 1997 and 2011 by ICD‐9‐CM code of 070.0/070.1. Patient sex, birthday, dates of hospitalization and death were analysed. A total of 3990 HAV‐hospitalized cases, males 2467 (62%), were identified. The LOS increased as patients’ age increased. The overall mortality rate was 16.8 per 1000 hospitalizations. Males had significantly higher case fatality rate than females (20.7 vs 10.5 per 1000 cases). The adjusted odds ratio (aOR) for death rose by age and increased rapidly over 40 years of age. The aOR and 95% confidence interval [95%CI] for aged 40–59 years and aged over 60 years were 7.89 (1.06–58.98) and 14.88 (2.02–109.40) compared to aged 0–19 years, respectively. Patients with chronic liver disease and cirrhosis had significantly higher risk of death (aOR=1.03 [1.01–1.04]), compared to those without liver disease. However, patients with liver disease, but no cirrhosis did not have higher risk of death (aOR=1.00 [0.99–1.01]). The aOR [95%CI] for LOS >9 day was 3.26 (1.96–5.40) compared to cases with LOS ≤9 days. Male sex, age over 40 years, cirrhotic liver and long LOS are significant factors associated with death in HAV‐hospitalized cases.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/jvh.12564</identifier><identifier>PMID: 27386835</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Cohort Studies ; death ; Fatalities ; Female ; HAV ; Health risk assessment ; Hepatitis ; Hepatitis A - epidemiology ; Hepatitis A - mortality ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Length of Stay ; liver cirrhosis ; Liver diseases ; Male ; Males ; Middle Aged ; Mortality ; Risk Factors ; sex difference ; Sex Factors ; Survival Analysis ; Taiwan - epidemiology ; Young Adult</subject><ispartof>Journal of viral hepatitis, 2016-11, Vol.23 (11), p.940-945</ispartof><rights>2016 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2016 The Authors. Journal of Viral Hepatitis Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4924-a72633addc77c59b2f686fe44cecdc6b7c6e76b95d16186def9c5dd1576ac2cf3</citedby><cites>FETCH-LOGICAL-c4924-a72633addc77c59b2f686fe44cecdc6b7c6e76b95d16186def9c5dd1576ac2cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjvh.12564$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjvh.12564$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27386835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, C.-M.</creatorcontrib><creatorcontrib>Chen, S. C.-C.</creatorcontrib><creatorcontrib>Yang, H.-Y.</creatorcontrib><creatorcontrib>Yang, S.-T.</creatorcontrib><creatorcontrib>Wang, C.-M.</creatorcontrib><title>Hospitalization and mortality due to hepatitis A in Taiwan: a 15-year nationwide cohort study</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>Summary
Hepatitis A virus (HAV) is the most common food‐borne hepatitis in the world. The study objectives were (i) to describe the epidemiology of HAV‐related hospitalizations during 1997–2011 in Taiwan, (ii) to examine the age effect on the length of stay (LOS) in hospital and (iii) to study the factors associated with death. The hospitalized cases were identified from the Taiwan National Health Insurance Research Database between 1997 and 2011 by ICD‐9‐CM code of 070.0/070.1. Patient sex, birthday, dates of hospitalization and death were analysed. A total of 3990 HAV‐hospitalized cases, males 2467 (62%), were identified. The LOS increased as patients’ age increased. The overall mortality rate was 16.8 per 1000 hospitalizations. Males had significantly higher case fatality rate than females (20.7 vs 10.5 per 1000 cases). The adjusted odds ratio (aOR) for death rose by age and increased rapidly over 40 years of age. The aOR and 95% confidence interval [95%CI] for aged 40–59 years and aged over 60 years were 7.89 (1.06–58.98) and 14.88 (2.02–109.40) compared to aged 0–19 years, respectively. Patients with chronic liver disease and cirrhosis had significantly higher risk of death (aOR=1.03 [1.01–1.04]), compared to those without liver disease. However, patients with liver disease, but no cirrhosis did not have higher risk of death (aOR=1.00 [0.99–1.01]). The aOR [95%CI] for LOS >9 day was 3.26 (1.96–5.40) compared to cases with LOS ≤9 days. Male sex, age over 40 years, cirrhotic liver and long LOS are significant factors associated with death in HAV‐hospitalized cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>death</subject><subject>Fatalities</subject><subject>Female</subject><subject>HAV</subject><subject>Health risk assessment</subject><subject>Hepatitis</subject><subject>Hepatitis A - epidemiology</subject><subject>Hepatitis A - mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Length of Stay</subject><subject>liver cirrhosis</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Risk Factors</subject><subject>sex difference</subject><subject>Sex Factors</subject><subject>Survival Analysis</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kEtLKzEYhoMoXqoL_4AE3HgWo5P7jDspHquIgnhZSUiTDE2dTmoyY53z609q1YVgNl9Invfl4wFgH-XHKJ2T6dvkGGHG6RrYRoSzDBclWV_eGc5yltMtsBPjNM8RwQxtgi0sSMELwrbB88jHuWtV7f6p1vkGqsbAmQ_Ll7aHprOw9XBi5-m3dRGeQdfAe-UWqjmFCiKW9VYF2HyEF85YqP0kxWFsO9Pvgo1K1dHufc4BePh7fj8cZde3F5fDs-tM0xLTTAnMCVHGaCE0K8e44gWvLKXaaqP5WGhuBR-XzCCOCm5sVWpmDGKCK411RQbgaNU7D_61s7GVMxe1rWvVWN9FiQrMBaIiCRiAwx_o1HehSdslitAlRnmi_qwoHXyMwVZyHtxMhV6iXC6dy-RcfjhP7MFnYzeeWfNNfklOwMkKWLja9r83yavH0Vdltkq42Nr374QKL5ILIph8urmQZDgqqMB3EpP_vySZ9w</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Chen, C.-M.</creator><creator>Chen, S. C.-C.</creator><creator>Yang, H.-Y.</creator><creator>Yang, S.-T.</creator><creator>Wang, C.-M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Hospitalization and mortality due to hepatitis A in Taiwan: a 15-year nationwide cohort study</title><author>Chen, C.-M. ; Chen, S. C.-C. ; Yang, H.-Y. ; Yang, S.-T. ; Wang, C.-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4924-a72633addc77c59b2f686fe44cecdc6b7c6e76b95d16186def9c5dd1576ac2cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>death</topic><topic>Fatalities</topic><topic>Female</topic><topic>HAV</topic><topic>Health risk assessment</topic><topic>Hepatitis</topic><topic>Hepatitis A - epidemiology</topic><topic>Hepatitis A - mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Length of Stay</topic><topic>liver cirrhosis</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Risk Factors</topic><topic>sex difference</topic><topic>Sex Factors</topic><topic>Survival Analysis</topic><topic>Taiwan - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, C.-M.</creatorcontrib><creatorcontrib>Chen, S. C.-C.</creatorcontrib><creatorcontrib>Yang, H.-Y.</creatorcontrib><creatorcontrib>Yang, S.-T.</creatorcontrib><creatorcontrib>Wang, C.-M.</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, C.-M.</au><au>Chen, S. C.-C.</au><au>Yang, H.-Y.</au><au>Yang, S.-T.</au><au>Wang, C.-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hospitalization and mortality due to hepatitis A in Taiwan: a 15-year nationwide cohort study</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2016-11</date><risdate>2016</risdate><volume>23</volume><issue>11</issue><spage>940</spage><epage>945</epage><pages>940-945</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>Summary
Hepatitis A virus (HAV) is the most common food‐borne hepatitis in the world. The study objectives were (i) to describe the epidemiology of HAV‐related hospitalizations during 1997–2011 in Taiwan, (ii) to examine the age effect on the length of stay (LOS) in hospital and (iii) to study the factors associated with death. The hospitalized cases were identified from the Taiwan National Health Insurance Research Database between 1997 and 2011 by ICD‐9‐CM code of 070.0/070.1. Patient sex, birthday, dates of hospitalization and death were analysed. A total of 3990 HAV‐hospitalized cases, males 2467 (62%), were identified. The LOS increased as patients’ age increased. The overall mortality rate was 16.8 per 1000 hospitalizations. Males had significantly higher case fatality rate than females (20.7 vs 10.5 per 1000 cases). The adjusted odds ratio (aOR) for death rose by age and increased rapidly over 40 years of age. The aOR and 95% confidence interval [95%CI] for aged 40–59 years and aged over 60 years were 7.89 (1.06–58.98) and 14.88 (2.02–109.40) compared to aged 0–19 years, respectively. Patients with chronic liver disease and cirrhosis had significantly higher risk of death (aOR=1.03 [1.01–1.04]), compared to those without liver disease. However, patients with liver disease, but no cirrhosis did not have higher risk of death (aOR=1.00 [0.99–1.01]). The aOR [95%CI] for LOS >9 day was 3.26 (1.96–5.40) compared to cases with LOS ≤9 days. Male sex, age over 40 years, cirrhotic liver and long LOS are significant factors associated with death in HAV‐hospitalized cases.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27386835</pmid><doi>10.1111/jvh.12564</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Age Factors Aged Aged, 80 and over Child Child, Preschool Cohort Studies death Fatalities Female HAV Health risk assessment Hepatitis Hepatitis A - epidemiology Hepatitis A - mortality Hospitalization Humans Infant Infant, Newborn Length of Stay liver cirrhosis Liver diseases Male Males Middle Aged Mortality Risk Factors sex difference Sex Factors Survival Analysis Taiwan - epidemiology Young Adult |
| title | Hospitalization and mortality due to hepatitis A in Taiwan: a 15-year nationwide cohort study |
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