Applying Physiologically Relevant Strains to Tenocytes in an In Vitro Cell Device Induces In Vivo Like Behaviors

We have developed a novel cell stretching device (called Cell Gym) capable of applying physiologically relevant low magnitude strains to tenocytes on a collagen type I coated membrane. We validated our device thoroughly on two levels: (1) substrate strains, (2) cell level strains. Our cell level str...

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Veröffentlicht in:	Journal of biomechanical engineering 2016-12, Vol.138 (12)
Hauptverfasser:	Joo Kim, Jung, Musson, David S, Matthews, Brya G, Cornish, Jillian, Anderson, Iain A, Shim, Vickie B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetics - instrumentation Cell Size Cells, Cultured Collagen - biosynthesis Compressive Strength - physiology Elastic Modulus - physiology Equipment Design Equipment Failure Analysis Female Mechanotransduction, Cellular - physiology Micro-Electrical-Mechanical Systems - instrumentation Micromanipulation - instrumentation Physical Stimulation - instrumentation Rats Rats, Wistar Stress, Mechanical Tenocytes - cytology Tenocytes - physiology Tensile Strength - physiology Tissue Scaffolds
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