Single‐ and Multiple‐Dose Pharmacokinetics of Immediate‐Release/Extended‐Release Ibuprofen Tablets

A single‐dose, randomized, open‐label, crossover study (study 1; n = 35) and a multiple‐dose, randomized, open‐label, crossover study (study 2; n = 28) compared the pharmacokinetics of a new immediate‐release/extended‐release (IR/ER) bilayer tablet formulation of ibuprofen 600 mg every 12 hours with...

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Veröffentlicht in:	Clinical pharmacology in drug development 2017-01, Vol.6 (1), p.36-43
Hauptverfasser:	Legg, Thomas, Paluch, Edward, Jayawardena, Shyamalie
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Adult Area Under Curve bioequivalence Cross-Over Studies Delayed-Action Preparations Fasting Female food effect Humans ibuprofen Ibuprofen - administration & dosage Ibuprofen - pharmacokinetics Male pharmacokinetics Tablets Therapeutic Equivalency Young Adult
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