An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers

The National Lung Cancer Screening Trial has confirmed that lung cancer mortality can be reduced if tumors are diagnosed early, that is, at stage I. However, a substantial fraction of stage I lung cancer patients still develop metastatic disease within 5 years from surgery. Prognostic biomarkers are...

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Veröffentlicht in:	Clinical cancer research 2017-01, Vol.23 (1), p.62-72
Hauptverfasser:	Dama, Elisa, Melocchi, Valentina, Dezi, Fabio, Pirroni, Stefania, Carletti, Rose Mary, Brambilla, Daniela, Bertalot, Giovanni, Casiraghi, Monica, Maisonneuve, Patrick, Barberis, Massimo, Viale, Giuseppe, Vecchi, Manuela, Spaggiari, Lorenzo, Bianchi, Fabrizio, Di Fiore, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma of Lung Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor Cancer Cancer screening Cohort Studies Confidence intervals Copy number Disease Progression DNA Copy Number Variations DNA Methylation Experimental design Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genomes Genomics - methods Health risks Humans Kaplan-Meier Estimate Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical screening Metastases Middle Aged Mutation Neoplasm Staging Paraffin Patients Prognosis Proportional Hazards Models Proteomics Risk analysis Risk Factors Surgery Tumors
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