Gulp1 is associated with the pharmacokinetics of PEGylated liposomal doxorubicin (PLD) in inbred mouse strains

Abstract Nanoparticles (NP) including liposomes are cleared by phagocytes of the mononuclear phagocyte system. High inter-patient variability in pharmacokinetics of PEGylated liposomal doxorubicin (PLD) has been reported. We hypothesized that genetic factors may be associated with the variable dispo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nanomedicine 2016-10, Vol.12 (7), p.2007-2017
Hauptverfasser:	Song, Gina, PharmD, PhD, Suzuki, Oscar T., PhD, Santos, Charlene M., RLATG, Lucas, Andrew T., PharmD, Wiltshire, Tim, PhD, Zamboni, William C., PharmD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Doxorubicin Gulp1 Humans Internal Medicine Kinetics Liposomes Male Mice Mice, Inbred Strains Nanoparticles Pharmacogenetics Pharmacogenomic Variants Pharmacokinetics PLD Polyethylene Glycols
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!