Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

Over the past decade, foldamers have progressively emerged as useful architectures to mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid based backbones, have been the most studied from a therapeutic perspective, while polyaromatic foldamers have barely evol...

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Veröffentlicht in:	Journal of medicinal chemistry 2016-11, Vol.59 (21), p.9599-9621
Hauptverfasser:	Gopalakrishnan, Ranganath, Frolov, Andrey I, Knerr, Laurent, Drury, William J, Valeur, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Discovery Humans Models, Molecular Molecular Structure Peptides - chemistry Peptides - pharmacology Peptides - therapeutic use Polycyclic Aromatic Hydrocarbons - chemistry Polycyclic Aromatic Hydrocarbons - pharmacology Polycyclic Aromatic Hydrocarbons - therapeutic use Protein Folding - drug effects
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