Artificial Biosensors: How Can Molecular Imprinting Mimic Biorecognition?
Receptors generated by natural evolution in living organisms show an astonishing capacity for specifically recognizing target molecules. If applied as recognition units of biosensors, these receptors provide very high selectivity. However, they suffer from instability under measurement conditions, a...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2016-11, Vol.34 (11), p.922-941 |
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| creator | Cieplak, Maciej Kutner, Włodzimierz |
| description | Receptors generated by natural evolution in living organisms show an astonishing capacity for specifically recognizing target molecules. If applied as recognition units of biosensors, these receptors provide very high selectivity. However, they suffer from instability under measurement conditions, and low durability. Devising alternative robust artificial receptors circumvents these deficiencies. For instance, an antibody can be successfully replaced by a corresponding molecularly imprinted polymer (MIP), sometimes called a ‘plastic antibody’. Therefore, MIPs used as recognition units in chemical sensors are gaining increasing interest. In this review, we survey selected examples of MIPs used for determining target bioanalytes by mimicking natural recognition. For scientists working with biosensors, MIPs might be considered as alternatives to natural receptors, such as antibodies, enzymes, or histones. |
| doi_str_mv | 10.1016/j.tibtech.2016.05.011 |
| format | Article |
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If applied as recognition units of biosensors, these receptors provide very high selectivity. However, they suffer from instability under measurement conditions, and low durability. Devising alternative robust artificial receptors circumvents these deficiencies. For instance, an antibody can be successfully replaced by a corresponding molecularly imprinted polymer (MIP), sometimes called a ‘plastic antibody’. Therefore, MIPs used as recognition units in chemical sensors are gaining increasing interest. In this review, we survey selected examples of MIPs used for determining target bioanalytes by mimicking natural recognition. For scientists working with biosensors, MIPs might be considered as alternatives to natural receptors, such as antibodies, enzymes, or histones.</description><identifier>ISSN: 0167-7799</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2016.05.011</identifier><identifier>PMID: 27289133</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; aptamer-DNA ; artificial biosensor ; artificial enzyme ; artificial immunosensor ; Biosensing Techniques ; biosensor ; Biosensors ; Carbon ; Chemical bonds ; chemosensor ; Electrodes ; Enzymes ; Glucose ; Humans ; Internal Medicine ; Mice ; Molecular Imprinting ; molecularly imprinted polymer (MIP) ; Oxidation ; Polymerization ; Polymers ; Proteins ; selective recognition ; Synthetic Biology</subject><ispartof>Trends in biotechnology (Regular ed.), 2016-11, Vol.34 (11), p.922-941</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. 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If applied as recognition units of biosensors, these receptors provide very high selectivity. However, they suffer from instability under measurement conditions, and low durability. Devising alternative robust artificial receptors circumvents these deficiencies. For instance, an antibody can be successfully replaced by a corresponding molecularly imprinted polymer (MIP), sometimes called a ‘plastic antibody’. Therefore, MIPs used as recognition units in chemical sensors are gaining increasing interest. In this review, we survey selected examples of MIPs used for determining target bioanalytes by mimicking natural recognition. For scientists working with biosensors, MIPs might be considered as alternatives to natural receptors, such as antibodies, enzymes, or histones.</description><subject>Animals</subject><subject>aptamer-DNA</subject><subject>artificial biosensor</subject><subject>artificial enzyme</subject><subject>artificial immunosensor</subject><subject>Biosensing Techniques</subject><subject>biosensor</subject><subject>Biosensors</subject><subject>Carbon</subject><subject>Chemical bonds</subject><subject>chemosensor</subject><subject>Electrodes</subject><subject>Enzymes</subject><subject>Glucose</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mice</subject><subject>Molecular Imprinting</subject><subject>molecularly imprinted polymer (MIP)</subject><subject>Oxidation</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Proteins</subject><subject>selective recognition</subject><subject>Synthetic 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| subjects | Animals aptamer-DNA artificial biosensor artificial enzyme artificial immunosensor Biosensing Techniques biosensor Biosensors Carbon Chemical bonds chemosensor Electrodes Enzymes Glucose Humans Internal Medicine Mice Molecular Imprinting molecularly imprinted polymer (MIP) Oxidation Polymerization Polymers Proteins selective recognition Synthetic Biology |
| title | Artificial Biosensors: How Can Molecular Imprinting Mimic Biorecognition? |
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