The regulatory role of smooth muscle 22 on the proliferation of aortic smooth muscle cells participates in the development of aortic dissection

Objective The aim of this study was to determine the role of smooth muscle 22 (SM22) in aortic dissection (AD) vascular remodeling and its regulatory mechanism on vascular smooth muscle cell function. Methods Seven patients who underwent surgery for AD with no genetic predisposition and seven organ...

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Veröffentlicht in:	Journal of vascular surgery 2017-09, Vol.66 (3), p.875-882
Hauptverfasser:	Sun, Yudong, MD, Zhao, Zhiqing, MD, Hou, Lewei, MD, Xiao, Yu, MD, Qin, Feng, MD, Yan, Junyi, BSc, Zhou, Jian, MD, Jing, Zaiping, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aneurysm, Dissecting - genetics Aneurysm, Dissecting - metabolism Aneurysm, Dissecting - pathology Aneurysm, Dissecting - physiopathology Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Aortic Aneurysm, Thoracic - genetics Aortic Aneurysm, Thoracic - metabolism Aortic Aneurysm, Thoracic - pathology Aortic Aneurysm, Thoracic - physiopathology Calcium - metabolism Calcium Signaling Cell Proliferation Cells, Cultured Down-Regulation Female Humans Male Microfilament Proteins - genetics Microfilament Proteins - metabolism Middle Aged Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Promoter Regions, Genetic RNA Interference Surgery Transcription, Genetic Transfection Vascular Remodeling
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