Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone

•UPC2-MS/MS show alternative pathway is dominant in PNT2 prostate cells.•11OHA4 metabolism in PNT2 cells is less efficient than in LNCaP cells.•11KDHT is efficiently glucuronidated in LNCaP cells while 11KT conjugation is poor.•In PCa tissue 11OHA4, 11KT, 11OHT and 11KDHT are present at significant...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2017-02, Vol.166, p.54-67
Hauptverfasser:	du Toit, Therina, Bloem, Liezl M., Quanson, Jonathan L., Ehlers, Riaan, Serafin, Antonio M., Swart, Amanda C.
Format:	Artikel
Sprache:	eng
Schlagworte:	11K-DHT 11keto-testosterone (11KT) Adrenal 11β -hydroxy-androstenedione (11β OHA4) Castration-resistant prostate cancer (CRPC) LC–MS/MS LNCaP prostate cancer cell model PNT2 epithelial prostate cell model
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