Influence of VKORC1 and CYP2C9 Polymorphisms on Daily Acenocoumarol Dose Requirement in South Indian Patients With Mechanical Heart Valves

Background and Aim: Chronic rheumatic heart disease (RHD) patients who undergo valve replacement with mechanical valves require lifelong anticoagulation. Acenocoumarol, a vitamin K antagonist has a narrow therapeutic range and wide inter-individual variability. Our aim was to investigate the influen...

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Veröffentlicht in:	Clinical and applied thrombosis/hemostasis 2017-10, Vol.23 (7), p.876-882
Hauptverfasser:	Kalpana, S. R., Bharath, G., Manjunath, C. N., Christopher, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Acenocoumarol - administration & dosage Cytochrome P-450 CYP2C9 - genetics Female Genotype Genotype & phenotype Heart Valve Prosthesis Humans India Male Polymorphism, Single Nucleotide - genetics Rheumatic Heart Disease - drug therapy Rheumatic Heart Disease - genetics Rheumatic Heart Disease - therapy Vitamin K Epoxide Reductases - genetics
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