Osteopontin expression in co-cultures of human squamous cell carcinoma-derived cells and osteoblastic cells and its effects on the neoplastic cell phenotype and osteoclastic activation

This study evaluated the temporal expression of osteopontin (OPN) in co-cultures of human osteoblastic cells (SAOS-2) and oral squamous cell carcinoma (OSCC)-derived cells (SCC9) and examined the effects of osteoblast-derived OPN on the neoplastic cell phenotype. Additionally, the effects of these c...

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Veröffentlicht in:	Tumor biology 2016-09, Vol.37 (9), p.12371-12385
Hauptverfasser:	Teixeira, Lucas Novaes, de Castro Raucci, Larissa Moreira Spinola, Alonso, Gabriela Caroline, Coletta, Ricardo Della, Rosa, Adalberto Luiz, de Oliveira, Paulo Tambasco
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Bone cancer Cancer Research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Adhesion - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Coculture Techniques Collagen Cytokines - metabolism Drug Combinations Enzyme-Linked Immunosorbent Assay Gene Expression Regulation, Neoplastic Genotype & phenotype Humans Laminin Microscopy, Fluorescence Oral cancer Original Article Osteoblasts - metabolism Osteoblasts - pathology Osteoclasts - metabolism Osteoclasts - pathology Osteopontin - genetics Osteopontin - metabolism Phenotype Proteoglycans Reverse Transcriptase Polymerase Chain Reaction Tumors U937 Cells
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