Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats
Scutellariae Radix (Scutellaria baicalensis Georgi) is a well-known Traditional Chinese Medicine (TCM) which mainly contains flavonoids. Our previous studies have demonstrated that total aglycone extracts of Scutellaria baicalensis (TAES) can improve kidney disease in rats. To investigate the renal...
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| Veröffentlicht in: | Journal of ethnopharmacology 2016-11, Vol.192, p.20-29 |
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| creator | Fang, Junwei Wang, Wenyu Sun, Shujun Wang, Yang Li, Qianhua Lu, Xiong Qiu, Mingfeng Zhang, Yongyu |
| description | Scutellariae Radix (Scutellaria baicalensis Georgi) is a well-known Traditional Chinese Medicine (TCM) which mainly contains flavonoids. Our previous studies have demonstrated that total aglycone extracts of Scutellaria baicalensis (TAES) can improve kidney disease in rats.
To investigate the renal fibrosis (RF) pathogenesis and TAES treatment mechanism in unilateral ureteral obstruction (UUO) rats, using a metabolomics approach based on gas chromatography-mass spectrometry (GC/MS).
Rats with RF were divided into 6 groups with rats subjected to sham operation as normal control. The effects of TAES on some RF closely related parameters in UUO rats were investigated. A metabolomics method, based on GC/MS, was developed to monitor metabolic alterations in urine. Multivariate data analysis was utilized to identify biomarkers potentially associated with RF and the anti-RF activity of TAES. Ontology-based enrichment analysis by BiNChE and pathway analysis by MetPA aid in the interpretation of difference metabolites.
After 10 days of treatment, the parameters of renal function begin returning to normal, and the abnormal high expressions of genes associated with extracellular matrix (ECM) were relived. In the metabolomics study, metabolic perturbations induced by UUO were reversed after treatment and TAES showed a dose-dependent therapy effect on RF, meanwhile, 18 potential biomarkers associated with RF were identified. Enrichment analysis of metabolites shows an over representation of mostly alkane-alpha, omega-diamine and alpha, omega-dicarboxylic acid, and these biomarkers are primarily involved in Glycine, serine and threonine metabolism, Retinol metabolism, Arginine and proline metabolism and Fructose and mannose metabolism.
Our findings indicate that TAES have positive effects on UUO-induced RF in rats, meanwhile, metabolomics method coupled with metabolites enrichment analysis is a useful tool for revealing the pathogenesis of diseases and action mechanism of TCM on the whole body.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2016.06.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826698752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874116303725</els_id><sourcerecordid>1826698752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-44bdc1fe4a043ca60e2aad3132ffb33e9fc21f151f61ec3629aaa5ba36216f0e3</originalsourceid><addsrcrecordid>eNp9kc-OFCEQxonRuLOrD-DFcPTSIwXdTU88mY1_NlnjQT2TarowTHpgBHrjPIsvK-2MHk0qoRJ-31dQH2MvQGxBQP96v93TcStruxW1oH3ENjBo2ehOq8dsI5QemkG3cMWuc94LITS04im7kloO_Q70hv36RAXHOMeDt5nnskwnHh1PFHDmzo8pZp85hon7UCg9UCg-Bk7OkS15RUssFcXv88nGQJx-loSXqy92KTTPmDzyEb3FmcJq5wNfgp-xGlbpkujcxDGXtNg_AxKW_Iw9cThnen45b9i39---3n5s7j9_uLt9e99Y1anStO04WXDUomiVxV6QRJwUKOncqBTtnJXgoAPXA1nVyx0idiPWDnonSN2wV2ffY4o_FsrFHHy268MDxSUbGGTf7wbdyYrCGbV1MTmRM8fkD5hOBoRZMzF7UzMxayZG1IK2al5e7JfxQNM_xd8QKvDmDFD95IOnZLL1FCxNPtUtmyn6_9j_Bj5tof4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826698752</pqid></control><display><type>article</type><title>Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Fang, Junwei ; Wang, Wenyu ; Sun, Shujun ; Wang, Yang ; Li, Qianhua ; Lu, Xiong ; Qiu, Mingfeng ; Zhang, Yongyu</creator><creatorcontrib>Fang, Junwei ; Wang, Wenyu ; Sun, Shujun ; Wang, Yang ; Li, Qianhua ; Lu, Xiong ; Qiu, Mingfeng ; Zhang, Yongyu</creatorcontrib><description>Scutellariae Radix (Scutellaria baicalensis Georgi) is a well-known Traditional Chinese Medicine (TCM) which mainly contains flavonoids. Our previous studies have demonstrated that total aglycone extracts of Scutellaria baicalensis (TAES) can improve kidney disease in rats.
To investigate the renal fibrosis (RF) pathogenesis and TAES treatment mechanism in unilateral ureteral obstruction (UUO) rats, using a metabolomics approach based on gas chromatography-mass spectrometry (GC/MS).
Rats with RF were divided into 6 groups with rats subjected to sham operation as normal control. The effects of TAES on some RF closely related parameters in UUO rats were investigated. A metabolomics method, based on GC/MS, was developed to monitor metabolic alterations in urine. Multivariate data analysis was utilized to identify biomarkers potentially associated with RF and the anti-RF activity of TAES. Ontology-based enrichment analysis by BiNChE and pathway analysis by MetPA aid in the interpretation of difference metabolites.
After 10 days of treatment, the parameters of renal function begin returning to normal, and the abnormal high expressions of genes associated with extracellular matrix (ECM) were relived. In the metabolomics study, metabolic perturbations induced by UUO were reversed after treatment and TAES showed a dose-dependent therapy effect on RF, meanwhile, 18 potential biomarkers associated with RF were identified. Enrichment analysis of metabolites shows an over representation of mostly alkane-alpha, omega-diamine and alpha, omega-dicarboxylic acid, and these biomarkers are primarily involved in Glycine, serine and threonine metabolism, Retinol metabolism, Arginine and proline metabolism and Fructose and mannose metabolism.
Our findings indicate that TAES have positive effects on UUO-induced RF in rats, meanwhile, metabolomics method coupled with metabolites enrichment analysis is a useful tool for revealing the pathogenesis of diseases and action mechanism of TCM on the whole body.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2016.06.014</identifier><identifier>PMID: 27286917</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology ; Animals ; Biomarkers - blood ; Biomarkers - urine ; Blood Urea Nitrogen ; Creatinine - blood ; Discriminant Analysis ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fibrosis ; Gas Chromatography-Mass Spectrometry ; GC/MS ; Hydroxyproline - urine ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Diseases - etiology ; Kidney Diseases - pathology ; Kidney Diseases - prevention & control ; Kidney Diseases - urine ; Losartan - pharmacology ; Male ; Metabolomics ; Metabolomics - methods ; Multivariate Analysis ; Phytotherapy ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal ; Principal Component Analysis ; Rats, Wistar ; Renal fibrosis ; Scutellaria baicalensis - classification ; Time Factors ; Total aglycone extracts of Scutellaria baicalensis ; Unilateral ureteral obstruction ; Ureteral Obstruction - complications ; Ureteral Obstruction - drug therapy ; Ureteral Obstruction - pathology ; Ureteral Obstruction - urine ; Urological Agents - isolation & purification ; Urological Agents - pharmacology</subject><ispartof>Journal of ethnopharmacology, 2016-11, Vol.192, p.20-29</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-44bdc1fe4a043ca60e2aad3132ffb33e9fc21f151f61ec3629aaa5ba36216f0e3</citedby><cites>FETCH-LOGICAL-c353t-44bdc1fe4a043ca60e2aad3132ffb33e9fc21f151f61ec3629aaa5ba36216f0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2016.06.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27286917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Junwei</creatorcontrib><creatorcontrib>Wang, Wenyu</creatorcontrib><creatorcontrib>Sun, Shujun</creatorcontrib><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Li, Qianhua</creatorcontrib><creatorcontrib>Lu, Xiong</creatorcontrib><creatorcontrib>Qiu, Mingfeng</creatorcontrib><creatorcontrib>Zhang, Yongyu</creatorcontrib><title>Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Scutellariae Radix (Scutellaria baicalensis Georgi) is a well-known Traditional Chinese Medicine (TCM) which mainly contains flavonoids. Our previous studies have demonstrated that total aglycone extracts of Scutellaria baicalensis (TAES) can improve kidney disease in rats.
To investigate the renal fibrosis (RF) pathogenesis and TAES treatment mechanism in unilateral ureteral obstruction (UUO) rats, using a metabolomics approach based on gas chromatography-mass spectrometry (GC/MS).
Rats with RF were divided into 6 groups with rats subjected to sham operation as normal control. The effects of TAES on some RF closely related parameters in UUO rats were investigated. A metabolomics method, based on GC/MS, was developed to monitor metabolic alterations in urine. Multivariate data analysis was utilized to identify biomarkers potentially associated with RF and the anti-RF activity of TAES. Ontology-based enrichment analysis by BiNChE and pathway analysis by MetPA aid in the interpretation of difference metabolites.
After 10 days of treatment, the parameters of renal function begin returning to normal, and the abnormal high expressions of genes associated with extracellular matrix (ECM) were relived. In the metabolomics study, metabolic perturbations induced by UUO were reversed after treatment and TAES showed a dose-dependent therapy effect on RF, meanwhile, 18 potential biomarkers associated with RF were identified. Enrichment analysis of metabolites shows an over representation of mostly alkane-alpha, omega-diamine and alpha, omega-dicarboxylic acid, and these biomarkers are primarily involved in Glycine, serine and threonine metabolism, Retinol metabolism, Arginine and proline metabolism and Fructose and mannose metabolism.
Our findings indicate that TAES have positive effects on UUO-induced RF in rats, meanwhile, metabolomics method coupled with metabolites enrichment analysis is a useful tool for revealing the pathogenesis of diseases and action mechanism of TCM on the whole body.
[Display omitted]</description><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine - blood</subject><subject>Discriminant Analysis</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fibrosis</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>GC/MS</subject><subject>Hydroxyproline - urine</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidney Diseases - urine</subject><subject>Losartan - pharmacology</subject><subject>Male</subject><subject>Metabolomics</subject><subject>Metabolomics - methods</subject><subject>Multivariate Analysis</subject><subject>Phytotherapy</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Principal Component Analysis</subject><subject>Rats, Wistar</subject><subject>Renal fibrosis</subject><subject>Scutellaria baicalensis - classification</subject><subject>Time Factors</subject><subject>Total aglycone extracts of Scutellaria baicalensis</subject><subject>Unilateral ureteral obstruction</subject><subject>Ureteral Obstruction - complications</subject><subject>Ureteral Obstruction - drug therapy</subject><subject>Ureteral Obstruction - pathology</subject><subject>Ureteral Obstruction - urine</subject><subject>Urological Agents - isolation & purification</subject><subject>Urological Agents - pharmacology</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-OFCEQxonRuLOrD-DFcPTSIwXdTU88mY1_NlnjQT2TarowTHpgBHrjPIsvK-2MHk0qoRJ-31dQH2MvQGxBQP96v93TcStruxW1oH3ENjBo2ehOq8dsI5QemkG3cMWuc94LITS04im7kloO_Q70hv36RAXHOMeDt5nnskwnHh1PFHDmzo8pZp85hon7UCg9UCg-Bk7OkS15RUssFcXv88nGQJx-loSXqy92KTTPmDzyEb3FmcJq5wNfgp-xGlbpkujcxDGXtNg_AxKW_Iw9cThnen45b9i39---3n5s7j9_uLt9e99Y1anStO04WXDUomiVxV6QRJwUKOncqBTtnJXgoAPXA1nVyx0idiPWDnonSN2wV2ffY4o_FsrFHHy268MDxSUbGGTf7wbdyYrCGbV1MTmRM8fkD5hOBoRZMzF7UzMxayZG1IK2al5e7JfxQNM_xd8QKvDmDFD95IOnZLL1FCxNPtUtmyn6_9j_Bj5tof4</recordid><startdate>20161104</startdate><enddate>20161104</enddate><creator>Fang, Junwei</creator><creator>Wang, Wenyu</creator><creator>Sun, Shujun</creator><creator>Wang, Yang</creator><creator>Li, Qianhua</creator><creator>Lu, Xiong</creator><creator>Qiu, Mingfeng</creator><creator>Zhang, Yongyu</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161104</creationdate><title>Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats</title><author>Fang, Junwei ; Wang, Wenyu ; Sun, Shujun ; Wang, Yang ; Li, Qianhua ; Lu, Xiong ; Qiu, Mingfeng ; Zhang, Yongyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-44bdc1fe4a043ca60e2aad3132ffb33e9fc21f151f61ec3629aaa5ba36216f0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Angiotensin II Type 1 Receptor Blockers - pharmacology</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood Urea Nitrogen</topic><topic>Creatinine - blood</topic><topic>Discriminant Analysis</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fibrosis</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>GC/MS</topic><topic>Hydroxyproline - urine</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidney Diseases - urine</topic><topic>Losartan - pharmacology</topic><topic>Male</topic><topic>Metabolomics</topic><topic>Metabolomics - methods</topic><topic>Multivariate Analysis</topic><topic>Phytotherapy</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Principal Component Analysis</topic><topic>Rats, Wistar</topic><topic>Renal fibrosis</topic><topic>Scutellaria baicalensis - classification</topic><topic>Time Factors</topic><topic>Total aglycone extracts of Scutellaria baicalensis</topic><topic>Unilateral ureteral obstruction</topic><topic>Ureteral Obstruction - complications</topic><topic>Ureteral Obstruction - drug therapy</topic><topic>Ureteral Obstruction - pathology</topic><topic>Ureteral Obstruction - urine</topic><topic>Urological Agents - isolation & purification</topic><topic>Urological Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Junwei</creatorcontrib><creatorcontrib>Wang, Wenyu</creatorcontrib><creatorcontrib>Sun, Shujun</creatorcontrib><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Li, Qianhua</creatorcontrib><creatorcontrib>Lu, Xiong</creatorcontrib><creatorcontrib>Qiu, Mingfeng</creatorcontrib><creatorcontrib>Zhang, Yongyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Junwei</au><au>Wang, Wenyu</au><au>Sun, Shujun</au><au>Wang, Yang</au><au>Li, Qianhua</au><au>Lu, Xiong</au><au>Qiu, Mingfeng</au><au>Zhang, Yongyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2016-11-04</date><risdate>2016</risdate><volume>192</volume><spage>20</spage><epage>29</epage><pages>20-29</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Scutellariae Radix (Scutellaria baicalensis Georgi) is a well-known Traditional Chinese Medicine (TCM) which mainly contains flavonoids. Our previous studies have demonstrated that total aglycone extracts of Scutellaria baicalensis (TAES) can improve kidney disease in rats.
To investigate the renal fibrosis (RF) pathogenesis and TAES treatment mechanism in unilateral ureteral obstruction (UUO) rats, using a metabolomics approach based on gas chromatography-mass spectrometry (GC/MS).
Rats with RF were divided into 6 groups with rats subjected to sham operation as normal control. The effects of TAES on some RF closely related parameters in UUO rats were investigated. A metabolomics method, based on GC/MS, was developed to monitor metabolic alterations in urine. Multivariate data analysis was utilized to identify biomarkers potentially associated with RF and the anti-RF activity of TAES. Ontology-based enrichment analysis by BiNChE and pathway analysis by MetPA aid in the interpretation of difference metabolites.
After 10 days of treatment, the parameters of renal function begin returning to normal, and the abnormal high expressions of genes associated with extracellular matrix (ECM) were relived. In the metabolomics study, metabolic perturbations induced by UUO were reversed after treatment and TAES showed a dose-dependent therapy effect on RF, meanwhile, 18 potential biomarkers associated with RF were identified. Enrichment analysis of metabolites shows an over representation of mostly alkane-alpha, omega-diamine and alpha, omega-dicarboxylic acid, and these biomarkers are primarily involved in Glycine, serine and threonine metabolism, Retinol metabolism, Arginine and proline metabolism and Fructose and mannose metabolism.
Our findings indicate that TAES have positive effects on UUO-induced RF in rats, meanwhile, metabolomics method coupled with metabolites enrichment analysis is a useful tool for revealing the pathogenesis of diseases and action mechanism of TCM on the whole body.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>27286917</pmid><doi>10.1016/j.jep.2016.06.014</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2016-11, Vol.192, p.20-29 |
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| subjects | Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Biomarkers - blood Biomarkers - urine Blood Urea Nitrogen Creatinine - blood Discriminant Analysis Disease Models, Animal Dose-Response Relationship, Drug Fibrosis Gas Chromatography-Mass Spectrometry GC/MS Hydroxyproline - urine Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - etiology Kidney Diseases - pathology Kidney Diseases - prevention & control Kidney Diseases - urine Losartan - pharmacology Male Metabolomics Metabolomics - methods Multivariate Analysis Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Principal Component Analysis Rats, Wistar Renal fibrosis Scutellaria baicalensis - classification Time Factors Total aglycone extracts of Scutellaria baicalensis Unilateral ureteral obstruction Ureteral Obstruction - complications Ureteral Obstruction - drug therapy Ureteral Obstruction - pathology Ureteral Obstruction - urine Urological Agents - isolation & purification Urological Agents - pharmacology |
| title | Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats |
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