Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis

Objectives/Hypothesis Idiopathic subglottic stenosis (iSGS) is a rare and devastating extrathoracic obstruction involving the lower laryngeal and upper tracheal airway. It arises without known antecedent injury or associated disease process. Persistent mucosal inflammation and a localized fibrotic r...

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Veröffentlicht in:	The Laryngoscope 2016-11, Vol.126 (11), p.E356-E361
Hauptverfasser:	Gelbard, Alexander, Katsantonis, Nicolas-George, Mizuta, Masanobu, Newcomb, Dawn, Rotsinger, Joseph, Rousseau, Bernard, Daniero, James J., Edell, Eric S., Ekbom, Dale C., Kasperbauer, Jan L., Hillel, Alexander T., Yang, Liying, Garrett, C. Gaelyn, Netterville, James L., Wootten, Christopher T., Francis, David O., Stratton, Charles, Jenkins, Kevin, McGregor, Tracy L., Gaddy, Jennifer A., Blackwell, Timothy S., Drake, Wonder P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Airway Obstruction - etiology Case-Control Studies Humans idiopathic subglottis stenosis IL-17 IL-17A Inflammation Mediators - physiology Interleukin-17 - physiology Interleukin-23 - physiology iSGS ISS laryngotracheal stenosis Larynx - metabolism Larynx - pathology Mucous membrane Pathogenesis Signal Transduction - physiology Trachea - metabolism Trachea - pathology tracheal stenosis Tracheal Stenosis - complications Tracheal Stenosis - metabolism Tracheal Stenosis - pathology
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