A Novel Human PTH Analog [Cys25]hPTH(1–34) Restores Bone Mass in Ovariectomized Mice

Context: Recently, an arginine-to-cysteine homozygous mutation at position 25 in mature PTH was reported in a Korean patient with hypoparathyroidism. Objective: To clarify whether the high bone mass phenotype observed in this patient was related to the hypoparathyroidism itself or to chronic elevati...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2016-10, Vol.101 (10), p.3700-3708
Hauptverfasser:	Bae, Chu Hyun, Kang, Myeongmo, Park, Clara Yongjoo, Park, Bo Mi, Zhang, Dongdong, Nam, Hee Jin, Yang, Yu-Mi, Shin, Dong Min, Choi, Je-Yong, Lim, Sung-Kil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Density - drug effects Cell Culture Techniques Female Mice Mice, Inbred C57BL Ovariectomy Parathyroid Hormone - analysis Parathyroid Hormone - genetics Parathyroid Hormone - pharmacology Signal Transduction - drug effects
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