Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone
Objectives The aim of this study was to prospectively evaluate the clinical efficacy and histological outcome of the autogenous tooth graft material (AutoBT) compared to that of anorganic bovine bone (Bio‐Oss®, Geistlich, Switzerland) in post‐extraction alveolar bone augmentation. Patients and Metho...
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| Veröffentlicht in: | Clinical oral implants research 2017-07, Vol.28 (7), p.809-815 |
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| creator | Pang, Kang‐Mi Um, In‐Woong Kim, Young‐Kyun Woo, Jae‐Man Kim, Soung‐Min Lee, Jong‐Ho |
| description | Objectives
The aim of this study was to prospectively evaluate the clinical efficacy and histological outcome of the autogenous tooth graft material (AutoBT) compared to that of anorganic bovine bone (Bio‐Oss®, Geistlich, Switzerland) in post‐extraction alveolar bone augmentation.
Patients and Methods
A total of 33 graft sites in 24 patients were included in this study. AutoBT was used in 21 sites of 15 patients and Bio‐Oss® was used in 12 sites of 9 patients for alveolar bone augmentation 2–4 weeks after dental extraction. Vertical dimension of grafted bone was measured both at the time of graft placement and at implant fixture placement after 6 months. Trephine cores were harvested for the histomorphometric evaluations during implant placement when feasible. The primary stability of implant fixture was also measured.
Results
Infection of graft material or graft bed was not observed and graft sites healed without any notable complications in both groups. The vertical dimensions of alveolar bone increased by 5.38 ± 2.65 mm in AutoBT group and 6.56 ± 3.54 mm in Bio‐Oss® group at 6 months post‐extraction. Histomorphometrically, new bone formation of AutoBT‐grafted site was 31.24 ± 13.87% while that of Bio‐Oss® was 35.00 ± 19.33%. The implant stability quotient (ISQ) of implants placed in AutoBT‐grafted sites measured 72.80 ± 10.81 while those placed in Bio‐Oss®‐grafted sites measured 70.0 ± 12.86. There were no statistically significant differences between measurements of the two groups.
Conclusion
Autogenous demineralized dentin matrix from extracted tooth grafted to extraction sockets for the augmentation of vertical dimension was as effective as augmentation using anorganic bovine bone. Both groups showed favorable wound healing, similar amount of implant stability, and histologically confirmed new bone formation. Thus, the results of this study suggest that autogenous tooth graft material is a viable option for alveolar bone augmentation following dental extraction. |
| doi_str_mv | 10.1111/clr.12885 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826695554</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826695554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-6cec803dee38be69b27703998d902e65575e8705528c212406a8f93f30aa2e5f3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhyMEokvhwAsgS1zKIe3YWTs2t2oFLdJKSAjOkdeZbF059uI425ZH4-kYdgsHJHzwH_nTN6P5VdVrDuec1oUL-ZwLreWTasEVQA0S-NNqAQZk3XLFT6oX03QLAMpo87w6Ea1ojVy2i-rn5VzSFmOaJ9bj6CNmG_wP7OkVi49stCX7ezbkNDK8L9m6Qp8lpXLDhpRZuUFm5-1ItC0-RZYGZsMeU7CZbVJEEg3oyntm2S6naUd3v0eWbezTeKjkgo_e2cCoEu1U1KVxZ7OfSHfnqZCNKW8tQWTcU48H8cvq2WDDhK8ez9Pq28cPX1fX9frz1afV5bp2jWxkrRw6DU2P2OgNKrMRbQuNMbo3IFBJ2UrULUgptBNcLEFZPZhmaMBagXJoTquzo5fa_z7jVLrRTw5DsBFpbB3XQikjpVwS-vYf9DbNOVJ3HTcClkoAaKLeHSlH85gyDt0u-9Hmh45D9zvQjgLtDoES--bROG9G7P-SfxIk4OII3PmAD_83dav1l6PyF5uvrgs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920462008</pqid></control><display><type>article</type><title>Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Pang, Kang‐Mi ; Um, In‐Woong ; Kim, Young‐Kyun ; Woo, Jae‐Man ; Kim, Soung‐Min ; Lee, Jong‐Ho</creator><creatorcontrib>Pang, Kang‐Mi ; Um, In‐Woong ; Kim, Young‐Kyun ; Woo, Jae‐Man ; Kim, Soung‐Min ; Lee, Jong‐Ho</creatorcontrib><description>Objectives
The aim of this study was to prospectively evaluate the clinical efficacy and histological outcome of the autogenous tooth graft material (AutoBT) compared to that of anorganic bovine bone (Bio‐Oss®, Geistlich, Switzerland) in post‐extraction alveolar bone augmentation.
Patients and Methods
A total of 33 graft sites in 24 patients were included in this study. AutoBT was used in 21 sites of 15 patients and Bio‐Oss® was used in 12 sites of 9 patients for alveolar bone augmentation 2–4 weeks after dental extraction. Vertical dimension of grafted bone was measured both at the time of graft placement and at implant fixture placement after 6 months. Trephine cores were harvested for the histomorphometric evaluations during implant placement when feasible. The primary stability of implant fixture was also measured.
Results
Infection of graft material or graft bed was not observed and graft sites healed without any notable complications in both groups. The vertical dimensions of alveolar bone increased by 5.38 ± 2.65 mm in AutoBT group and 6.56 ± 3.54 mm in Bio‐Oss® group at 6 months post‐extraction. Histomorphometrically, new bone formation of AutoBT‐grafted site was 31.24 ± 13.87% while that of Bio‐Oss® was 35.00 ± 19.33%. The implant stability quotient (ISQ) of implants placed in AutoBT‐grafted sites measured 72.80 ± 10.81 while those placed in Bio‐Oss®‐grafted sites measured 70.0 ± 12.86. There were no statistically significant differences between measurements of the two groups.
Conclusion
Autogenous demineralized dentin matrix from extracted tooth grafted to extraction sockets for the augmentation of vertical dimension was as effective as augmentation using anorganic bovine bone. Both groups showed favorable wound healing, similar amount of implant stability, and histologically confirmed new bone formation. Thus, the results of this study suggest that autogenous tooth graft material is a viable option for alveolar bone augmentation following dental extraction.</description><identifier>ISSN: 0905-7161</identifier><identifier>EISSN: 1600-0501</identifier><identifier>DOI: 10.1111/clr.12885</identifier><identifier>PMID: 27279547</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Alveolar bone ; Alveolar Ridge Augmentation - methods ; Animals ; Augmentation ; Bone grafts ; Bone growth ; Bone healing ; bone regeneration ; bone substitutes ; Cattle ; clinical research ; Clinical trials ; Complications ; Cores ; Demineralizing ; Dental Implantation, Endosseous ; Dental materials ; Dental prosthetics ; Dentin ; Dentin - transplantation ; Dentistry ; Extraction ; Feasibility studies ; Female ; Grafting ; guided tissue regeneration ; histo‐pathology ; host mechanisms ; Humans ; Implants ; Infections ; Male ; Middle Aged ; Minerals ; Osteogenesis ; Patients ; Placement ; Prospective Studies ; Republic of Korea ; Skin & tissue grafts ; Sockets ; Stability analysis ; Statistical analysis ; Teeth ; Tooth Extraction ; Tooth Socket - surgery ; Transplantation, Autologous ; Transplants & implants ; Treatment Outcome ; Vertical Dimension ; Wound healing</subject><ispartof>Clinical oral implants research, 2017-07, Vol.28 (7), p.809-815</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-6cec803dee38be69b27703998d902e65575e8705528c212406a8f93f30aa2e5f3</citedby><cites>FETCH-LOGICAL-c3535-6cec803dee38be69b27703998d902e65575e8705528c212406a8f93f30aa2e5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fclr.12885$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fclr.12885$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27279547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Kang‐Mi</creatorcontrib><creatorcontrib>Um, In‐Woong</creatorcontrib><creatorcontrib>Kim, Young‐Kyun</creatorcontrib><creatorcontrib>Woo, Jae‐Man</creatorcontrib><creatorcontrib>Kim, Soung‐Min</creatorcontrib><creatorcontrib>Lee, Jong‐Ho</creatorcontrib><title>Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone</title><title>Clinical oral implants research</title><addtitle>Clin Oral Implants Res</addtitle><description>Objectives
The aim of this study was to prospectively evaluate the clinical efficacy and histological outcome of the autogenous tooth graft material (AutoBT) compared to that of anorganic bovine bone (Bio‐Oss®, Geistlich, Switzerland) in post‐extraction alveolar bone augmentation.
Patients and Methods
A total of 33 graft sites in 24 patients were included in this study. AutoBT was used in 21 sites of 15 patients and Bio‐Oss® was used in 12 sites of 9 patients for alveolar bone augmentation 2–4 weeks after dental extraction. Vertical dimension of grafted bone was measured both at the time of graft placement and at implant fixture placement after 6 months. Trephine cores were harvested for the histomorphometric evaluations during implant placement when feasible. The primary stability of implant fixture was also measured.
Results
Infection of graft material or graft bed was not observed and graft sites healed without any notable complications in both groups. The vertical dimensions of alveolar bone increased by 5.38 ± 2.65 mm in AutoBT group and 6.56 ± 3.54 mm in Bio‐Oss® group at 6 months post‐extraction. Histomorphometrically, new bone formation of AutoBT‐grafted site was 31.24 ± 13.87% while that of Bio‐Oss® was 35.00 ± 19.33%. The implant stability quotient (ISQ) of implants placed in AutoBT‐grafted sites measured 72.80 ± 10.81 while those placed in Bio‐Oss®‐grafted sites measured 70.0 ± 12.86. There were no statistically significant differences between measurements of the two groups.
Conclusion
Autogenous demineralized dentin matrix from extracted tooth grafted to extraction sockets for the augmentation of vertical dimension was as effective as augmentation using anorganic bovine bone. Both groups showed favorable wound healing, similar amount of implant stability, and histologically confirmed new bone formation. Thus, the results of this study suggest that autogenous tooth graft material is a viable option for alveolar bone augmentation following dental extraction.</description><subject>Alveolar bone</subject><subject>Alveolar Ridge Augmentation - methods</subject><subject>Animals</subject><subject>Augmentation</subject><subject>Bone grafts</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>bone regeneration</subject><subject>bone substitutes</subject><subject>Cattle</subject><subject>clinical research</subject><subject>Clinical trials</subject><subject>Complications</subject><subject>Cores</subject><subject>Demineralizing</subject><subject>Dental Implantation, Endosseous</subject><subject>Dental materials</subject><subject>Dental prosthetics</subject><subject>Dentin</subject><subject>Dentin - transplantation</subject><subject>Dentistry</subject><subject>Extraction</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Grafting</subject><subject>guided tissue regeneration</subject><subject>histo‐pathology</subject><subject>host mechanisms</subject><subject>Humans</subject><subject>Implants</subject><subject>Infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minerals</subject><subject>Osteogenesis</subject><subject>Patients</subject><subject>Placement</subject><subject>Prospective Studies</subject><subject>Republic of Korea</subject><subject>Skin & tissue grafts</subject><subject>Sockets</subject><subject>Stability analysis</subject><subject>Statistical analysis</subject><subject>Teeth</subject><subject>Tooth Extraction</subject><subject>Tooth Socket - surgery</subject><subject>Transplantation, Autologous</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Vertical Dimension</subject><subject>Wound healing</subject><issn>0905-7161</issn><issn>1600-0501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQhyMEokvhwAsgS1zKIe3YWTs2t2oFLdJKSAjOkdeZbF059uI425ZH4-kYdgsHJHzwH_nTN6P5VdVrDuec1oUL-ZwLreWTasEVQA0S-NNqAQZk3XLFT6oX03QLAMpo87w6Ea1ojVy2i-rn5VzSFmOaJ9bj6CNmG_wP7OkVi49stCX7ezbkNDK8L9m6Qp8lpXLDhpRZuUFm5-1ItC0-RZYGZsMeU7CZbVJEEg3oyntm2S6naUd3v0eWbezTeKjkgo_e2cCoEu1U1KVxZ7OfSHfnqZCNKW8tQWTcU48H8cvq2WDDhK8ez9Pq28cPX1fX9frz1afV5bp2jWxkrRw6DU2P2OgNKrMRbQuNMbo3IFBJ2UrULUgptBNcLEFZPZhmaMBagXJoTquzo5fa_z7jVLrRTw5DsBFpbB3XQikjpVwS-vYf9DbNOVJ3HTcClkoAaKLeHSlH85gyDt0u-9Hmh45D9zvQjgLtDoES--bROG9G7P-SfxIk4OII3PmAD_83dav1l6PyF5uvrgs</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Pang, Kang‐Mi</creator><creator>Um, In‐Woong</creator><creator>Kim, Young‐Kyun</creator><creator>Woo, Jae‐Man</creator><creator>Kim, Soung‐Min</creator><creator>Lee, Jong‐Ho</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone</title><author>Pang, Kang‐Mi ; Um, In‐Woong ; Kim, Young‐Kyun ; Woo, Jae‐Man ; Kim, Soung‐Min ; Lee, Jong‐Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-6cec803dee38be69b27703998d902e65575e8705528c212406a8f93f30aa2e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alveolar bone</topic><topic>Alveolar Ridge Augmentation - methods</topic><topic>Animals</topic><topic>Augmentation</topic><topic>Bone grafts</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>bone regeneration</topic><topic>bone substitutes</topic><topic>Cattle</topic><topic>clinical research</topic><topic>Clinical trials</topic><topic>Complications</topic><topic>Cores</topic><topic>Demineralizing</topic><topic>Dental Implantation, Endosseous</topic><topic>Dental materials</topic><topic>Dental prosthetics</topic><topic>Dentin</topic><topic>Dentin - transplantation</topic><topic>Dentistry</topic><topic>Extraction</topic><topic>Feasibility studies</topic><topic>Female</topic><topic>Grafting</topic><topic>guided tissue regeneration</topic><topic>histo‐pathology</topic><topic>host mechanisms</topic><topic>Humans</topic><topic>Implants</topic><topic>Infections</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minerals</topic><topic>Osteogenesis</topic><topic>Patients</topic><topic>Placement</topic><topic>Prospective Studies</topic><topic>Republic of Korea</topic><topic>Skin & tissue grafts</topic><topic>Sockets</topic><topic>Stability analysis</topic><topic>Statistical analysis</topic><topic>Teeth</topic><topic>Tooth Extraction</topic><topic>Tooth Socket - surgery</topic><topic>Transplantation, Autologous</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Vertical Dimension</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Kang‐Mi</creatorcontrib><creatorcontrib>Um, In‐Woong</creatorcontrib><creatorcontrib>Kim, Young‐Kyun</creatorcontrib><creatorcontrib>Woo, Jae‐Man</creatorcontrib><creatorcontrib>Kim, Soung‐Min</creatorcontrib><creatorcontrib>Lee, Jong‐Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral implants research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Kang‐Mi</au><au>Um, In‐Woong</au><au>Kim, Young‐Kyun</au><au>Woo, Jae‐Man</au><au>Kim, Soung‐Min</au><au>Lee, Jong‐Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone</atitle><jtitle>Clinical oral implants research</jtitle><addtitle>Clin Oral Implants Res</addtitle><date>2017-07</date><risdate>2017</risdate><volume>28</volume><issue>7</issue><spage>809</spage><epage>815</epage><pages>809-815</pages><issn>0905-7161</issn><eissn>1600-0501</eissn><abstract>Objectives
The aim of this study was to prospectively evaluate the clinical efficacy and histological outcome of the autogenous tooth graft material (AutoBT) compared to that of anorganic bovine bone (Bio‐Oss®, Geistlich, Switzerland) in post‐extraction alveolar bone augmentation.
Patients and Methods
A total of 33 graft sites in 24 patients were included in this study. AutoBT was used in 21 sites of 15 patients and Bio‐Oss® was used in 12 sites of 9 patients for alveolar bone augmentation 2–4 weeks after dental extraction. Vertical dimension of grafted bone was measured both at the time of graft placement and at implant fixture placement after 6 months. Trephine cores were harvested for the histomorphometric evaluations during implant placement when feasible. The primary stability of implant fixture was also measured.
Results
Infection of graft material or graft bed was not observed and graft sites healed without any notable complications in both groups. The vertical dimensions of alveolar bone increased by 5.38 ± 2.65 mm in AutoBT group and 6.56 ± 3.54 mm in Bio‐Oss® group at 6 months post‐extraction. Histomorphometrically, new bone formation of AutoBT‐grafted site was 31.24 ± 13.87% while that of Bio‐Oss® was 35.00 ± 19.33%. The implant stability quotient (ISQ) of implants placed in AutoBT‐grafted sites measured 72.80 ± 10.81 while those placed in Bio‐Oss®‐grafted sites measured 70.0 ± 12.86. There were no statistically significant differences between measurements of the two groups.
Conclusion
Autogenous demineralized dentin matrix from extracted tooth grafted to extraction sockets for the augmentation of vertical dimension was as effective as augmentation using anorganic bovine bone. Both groups showed favorable wound healing, similar amount of implant stability, and histologically confirmed new bone formation. Thus, the results of this study suggest that autogenous tooth graft material is a viable option for alveolar bone augmentation following dental extraction.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27279547</pmid><doi>10.1111/clr.12885</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alveolar bone Alveolar Ridge Augmentation - methods Animals Augmentation Bone grafts Bone growth Bone healing bone regeneration bone substitutes Cattle clinical research Clinical trials Complications Cores Demineralizing Dental Implantation, Endosseous Dental materials Dental prosthetics Dentin Dentin - transplantation Dentistry Extraction Feasibility studies Female Grafting guided tissue regeneration histo‐pathology host mechanisms Humans Implants Infections Male Middle Aged Minerals Osteogenesis Patients Placement Prospective Studies Republic of Korea Skin & tissue grafts Sockets Stability analysis Statistical analysis Teeth Tooth Extraction Tooth Socket - surgery Transplantation, Autologous Transplants & implants Treatment Outcome Vertical Dimension Wound healing |
| title | Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: a prospective randomized clinical trial in comparison with anorganic bovine bone |
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