Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers
Background Urinary dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid are established tests for diagnosis and monitoring of neuroblastic disease. We compared the diagnostic performance of total urinary 3-methoxytyramine, the O-methylated product of dopamine, to these three established...
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| Veröffentlicht in: | Annals of clinical biochemistry 2017-03, Vol.54 (2), p.264-272 |
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| creator | Lam, Leo Woollard, Gerald A Teague, Lochie Davidson, James S |
| description | Background
Urinary dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid are established tests for diagnosis and monitoring of neuroblastic disease. We compared the diagnostic performance of total urinary 3-methoxytyramine, the O-methylated product of dopamine, to these three established tumour markers.
Methods
Urinary 3-methoxytyramine, dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid were measured by high-performance liquid chromatography with electrochemical detection on consecutive urine samples from histologically proven neuroblastic patients and controls. Patients with neuroblastic disease were further classified as untreated, advancing, residual or absent disease based on clinical and radiological criteria. Receiver operating characteristic curve analysis was used to compare the diagnostic performance of the four tumour markers.
Results
Urinary 3-methoxytyramine was well correlated with established tumour markers and its concentration correlated with disease activity. It was the most commonly elevated tumour marker in neuroblastic disease and showed similar sensitivity to dopamine and homovanillic acid. The diagnostic utility of urinary 3-methoxytyramine as measured by area under the receiver operating characteristic curve was similar to dopamine and homovanillic acid.
Conclusion
Our results support the use of urinary 3-methoxytyramine as a tumour marker in the diagnosis and the monitoring of neuroblastoma disease. |
| doi_str_mv | 10.1177/0004563216654723 |
| format | Article |
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Urinary dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid are established tests for diagnosis and monitoring of neuroblastic disease. We compared the diagnostic performance of total urinary 3-methoxytyramine, the O-methylated product of dopamine, to these three established tumour markers.
Methods
Urinary 3-methoxytyramine, dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid were measured by high-performance liquid chromatography with electrochemical detection on consecutive urine samples from histologically proven neuroblastic patients and controls. Patients with neuroblastic disease were further classified as untreated, advancing, residual or absent disease based on clinical and radiological criteria. Receiver operating characteristic curve analysis was used to compare the diagnostic performance of the four tumour markers.
Results
Urinary 3-methoxytyramine was well correlated with established tumour markers and its concentration correlated with disease activity. It was the most commonly elevated tumour marker in neuroblastic disease and showed similar sensitivity to dopamine and homovanillic acid. The diagnostic utility of urinary 3-methoxytyramine as measured by area under the receiver operating characteristic curve was similar to dopamine and homovanillic acid.
Conclusion
Our results support the use of urinary 3-methoxytyramine as a tumour marker in the diagnosis and the monitoring of neuroblastoma disease.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/0004563216654723</identifier><identifier>PMID: 27235704</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biomarkers, Tumor - urine ; Case-Control Studies ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Dopamine - analogs & derivatives ; Dopamine - urine ; Female ; Homovanillic Acid - urine ; Humans ; Infant ; Infant, Newborn ; Male ; Metanephrine - urine ; Neoplasm Staging ; Neoplasm, Residual ; Nervous System Neoplasms - diagnosis ; Nervous System Neoplasms - pathology ; Nervous System Neoplasms - urine ; Neuroblastoma - diagnosis ; Neuroblastoma - pathology ; Neuroblastoma - urine ; ROC Curve ; Sympathetic Nervous System - metabolism ; Sympathetic Nervous System - pathology ; Vanilmandelic Acid - urine</subject><ispartof>Annals of clinical biochemistry, 2017-03, Vol.54 (2), p.264-272</ispartof><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-f556babf7ac183f21ab38974711f4848452082e031f723111e4cd4701e9d3333</citedby><cites>FETCH-LOGICAL-c379t-f556babf7ac183f21ab38974711f4848452082e031f723111e4cd4701e9d3333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0004563216654723$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0004563216654723$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27235704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Leo</creatorcontrib><creatorcontrib>Woollard, Gerald A</creatorcontrib><creatorcontrib>Teague, Lochie</creatorcontrib><creatorcontrib>Davidson, James S</creatorcontrib><title>Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers</title><title>Annals of clinical biochemistry</title><addtitle>Ann Clin Biochem</addtitle><description>Background
Urinary dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid are established tests for diagnosis and monitoring of neuroblastic disease. We compared the diagnostic performance of total urinary 3-methoxytyramine, the O-methylated product of dopamine, to these three established tumour markers.
Methods
Urinary 3-methoxytyramine, dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid were measured by high-performance liquid chromatography with electrochemical detection on consecutive urine samples from histologically proven neuroblastic patients and controls. Patients with neuroblastic disease were further classified as untreated, advancing, residual or absent disease based on clinical and radiological criteria. Receiver operating characteristic curve analysis was used to compare the diagnostic performance of the four tumour markers.
Results
Urinary 3-methoxytyramine was well correlated with established tumour markers and its concentration correlated with disease activity. It was the most commonly elevated tumour marker in neuroblastic disease and showed similar sensitivity to dopamine and homovanillic acid. The diagnostic utility of urinary 3-methoxytyramine as measured by area under the receiver operating characteristic curve was similar to dopamine and homovanillic acid.
Conclusion
Our results support the use of urinary 3-methoxytyramine as a tumour marker in the diagnosis and the monitoring of neuroblastoma disease.</description><subject>Biomarkers, Tumor - urine</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dopamine - analogs & derivatives</subject><subject>Dopamine - urine</subject><subject>Female</subject><subject>Homovanillic Acid - urine</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Metanephrine - urine</subject><subject>Neoplasm Staging</subject><subject>Neoplasm, Residual</subject><subject>Nervous System Neoplasms - diagnosis</subject><subject>Nervous System Neoplasms - pathology</subject><subject>Nervous System Neoplasms - urine</subject><subject>Neuroblastoma - diagnosis</subject><subject>Neuroblastoma - pathology</subject><subject>Neuroblastoma - urine</subject><subject>ROC Curve</subject><subject>Sympathetic Nervous System - metabolism</subject><subject>Sympathetic Nervous System - pathology</subject><subject>Vanilmandelic Acid - urine</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAQgC0EglLYmZBHloAvTuJ0RBUvCYmle3RxHOrixMV2gP4E_jUO5SEhYQ_W3X33yXeEnAA7BxDigjGW5QVPoSjyTKR8h0xA5GUCjMEumYzlZKwfkEPvVzFMBWP75CCNbC5YNiHvc6N7LdHQFzS6waBtT21LB6d7RXnSqbC0b5uwcdiNGfQUaa1th-5JuZHs1eBsbdCHmKTYN1Tabo1O-2h61WFJbVhGVGJQcmnNpydxysS4-VX5I7LXovHq-OudksX11WJ-m9w_3NzNL-8TycUsJG2eFzXWrUAJJW9TwJqXM5EJgDYr481TVqaKcWjjkACgMtlkgoGaNTyeKTnbatfOPg_Kh6rTXipjsFd28BWUaVHMeJHlEWVbVDrrvVNttXY6_nZTAavG_Vd_9x9bTr_sQ92p5qfhe-ERSLaAx0dVrezg-jjs_8IP4NCOtA</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Lam, Leo</creator><creator>Woollard, Gerald A</creator><creator>Teague, Lochie</creator><creator>Davidson, James S</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers</title><author>Lam, Leo ; Woollard, Gerald A ; Teague, Lochie ; Davidson, James S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-f556babf7ac183f21ab38974711f4848452082e031f723111e4cd4701e9d3333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers, Tumor - urine</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dopamine - analogs & derivatives</topic><topic>Dopamine - urine</topic><topic>Female</topic><topic>Homovanillic Acid - urine</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Metanephrine - urine</topic><topic>Neoplasm Staging</topic><topic>Neoplasm, Residual</topic><topic>Nervous System Neoplasms - diagnosis</topic><topic>Nervous System Neoplasms - pathology</topic><topic>Nervous System Neoplasms - urine</topic><topic>Neuroblastoma - diagnosis</topic><topic>Neuroblastoma - pathology</topic><topic>Neuroblastoma - urine</topic><topic>ROC Curve</topic><topic>Sympathetic Nervous System - metabolism</topic><topic>Sympathetic Nervous System - pathology</topic><topic>Vanilmandelic Acid - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Leo</creatorcontrib><creatorcontrib>Woollard, Gerald A</creatorcontrib><creatorcontrib>Teague, Lochie</creatorcontrib><creatorcontrib>Davidson, James S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Leo</au><au>Woollard, Gerald A</au><au>Teague, Lochie</au><au>Davidson, James S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>2017-03</date><risdate>2017</risdate><volume>54</volume><issue>2</issue><spage>264</spage><epage>272</epage><pages>264-272</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><abstract>Background
Urinary dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid are established tests for diagnosis and monitoring of neuroblastic disease. We compared the diagnostic performance of total urinary 3-methoxytyramine, the O-methylated product of dopamine, to these three established tumour markers.
Methods
Urinary 3-methoxytyramine, dopamine, homovanillic acid and 4-hydroxy-3-methoxymandelic acid were measured by high-performance liquid chromatography with electrochemical detection on consecutive urine samples from histologically proven neuroblastic patients and controls. Patients with neuroblastic disease were further classified as untreated, advancing, residual or absent disease based on clinical and radiological criteria. Receiver operating characteristic curve analysis was used to compare the diagnostic performance of the four tumour markers.
Results
Urinary 3-methoxytyramine was well correlated with established tumour markers and its concentration correlated with disease activity. It was the most commonly elevated tumour marker in neuroblastic disease and showed similar sensitivity to dopamine and homovanillic acid. The diagnostic utility of urinary 3-methoxytyramine as measured by area under the receiver operating characteristic curve was similar to dopamine and homovanillic acid.
Conclusion
Our results support the use of urinary 3-methoxytyramine as a tumour marker in the diagnosis and the monitoring of neuroblastoma disease.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27235704</pmid><doi>10.1177/0004563216654723</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of clinical biochemistry, 2017-03, Vol.54 (2), p.264-272 |
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| subjects | Biomarkers, Tumor - urine Case-Control Studies Child Child, Preschool Chromatography, High Pressure Liquid Dopamine - analogs & derivatives Dopamine - urine Female Homovanillic Acid - urine Humans Infant Infant, Newborn Male Metanephrine - urine Neoplasm Staging Neoplasm, Residual Nervous System Neoplasms - diagnosis Nervous System Neoplasms - pathology Nervous System Neoplasms - urine Neuroblastoma - diagnosis Neuroblastoma - pathology Neuroblastoma - urine ROC Curve Sympathetic Nervous System - metabolism Sympathetic Nervous System - pathology Vanilmandelic Acid - urine |
| title | Clinical validation of urine 3-methoxytyramine as a biomarker of neuroblastoma and comparison with other catecholamine-related biomarkers |
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