Changes in cognitive functions and cerebral grey matter and their associations with inflammatory markers, endocrine markers, and APOE genotypes in testicular cancer patients undergoing treatment

Evidence suggests that testicular cancer (TC) and its treatment are associated with cognitive impairment. However, the underlying neural substrate and biological mechanisms are poorly understood. This study aimed to investigate changes in cognition and brain grey matter (GM) morphology in TC patient...

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Veröffentlicht in:	Brain imaging and behavior 2017-06, Vol.11 (3), p.769-783
Hauptverfasser:	Amidi, Ali, Agerbæk, Mads, Wu, Lisa M., Pedersen, Anders D., Mehlsen, Mimi, Clausen, Cecilie R., Demontis, Ditte, Børglum, Anders D., Harbøll, Anja, Zachariae, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents - therapeutic use Apolipoprotein E Apolipoproteins E - genetics Assessments Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Brain Brain - diagnostic imaging C-Reactive Protein - metabolism Cancer Chemotherapy Cognition Cognition & reasoning Cognition - physiology Cognitive ability Computed tomography Follow-Up Studies Genotypes Gray Matter - diagnostic imaging Group dynamics Humans Impairment Inflammation Interleukin-6 - blood Magnetic Resonance Imaging Male Markers Matching Measuring techniques Morphology Morphometry Neuroimaging Neuropsychological Tests Neuropsychology Neuroradiology Neurosciences Orchiectomy Original Research Patients Psychiatry Psychology Regression analysis Resonance Substantia grisea Surgery Testes Testicular cancer Testicular Neoplasms - diagnostic imaging Testicular Neoplasms - metabolism Testicular Neoplasms - psychology Testicular Neoplasms - therapy Treatment Outcome Tumor necrosis factor Tumor Necrosis Factor-alpha - blood
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