Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection

Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection

Highlights • Microfluidic nitric oxide sensor is used to directly measure nitric oxide levels in fresh whole blood. • Increased nitric oxide production measured in mice infected with Pseudomonas aeruginosa. • Significantly diminished nitric oxide levels observed in infected animals that had suffered...

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Veröffentlicht in:Burns 2016-11, Vol.42 (7), p.1522-1527
Hauptverfasser: Dunn, Julia L.M, Hunter, Rebecca A, Gast, Karli, Maile, Robert, Cairns, Bruce A, Schoenfisch, Mark H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Burn
Burns - blood
Compensatory anti-inflammatory response syndrome
Critical Care
Disease Models, Animal
Electrochemistry
Female
Mice
Mice, Inbred C57BL
Microfluidic sensor
Nitric oxide
Nitric Oxide - blood
Pneumonia
Pneumonia, Bacterial - blood
Pseudomonas aeruginosa
Pseudomonas Infections - blood
Sepsis
Sepsis - blood
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Zusammenfassung:Highlights • Microfluidic nitric oxide sensor is used to directly measure nitric oxide levels in fresh whole blood. • Increased nitric oxide production measured in mice infected with Pseudomonas aeruginosa. • Significantly diminished nitric oxide levels observed in infected animals that had suffered a burn 14 d prior.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2016.05.005