Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study
Objectives/Hypothesis To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy. Methods A prospective randomized controlled trial in patients with CRS of...
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| Veröffentlicht in: | The Laryngoscope 2016-12, Vol.126 (12), p.2652-2658 |
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| container_title | The Laryngoscope |
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| creator | Bizaki, Argyro J. Numminen, Jura Taulu, Rami Kholova, Ivana Rautiainen, Markus |
| description | Objectives/Hypothesis
To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy.
Methods
A prospective randomized controlled trial in patients with CRS of the maxillary sinuses without severe pathology of other sinuses. Patients were randomized into two groups: uncinectomy and balloon sinuplasty. The main variables in our study are histopathology of nasal mucosa and expression of metalloproteinase‐9 protein. These parameters were analyzed preoperatively and at 3 months, 6 months, and 12 months postoperatively.
Results
Thickened epithelium, absence of cilia, metaplasia of epithelium, hyperplasia of mucosal glands, angiogenesis, and increased inflammatory cells were observed in the majority of preoperative samples. History of allergy was associated with a higher number of goblet cells, and shedding of epithelium was associated with worse quality of life. A higher number of inflammatory cells were associated with an increased number of goblet cells preoperatively, as well as after treatment. Both treatments resulted in a decrease of inflammation in the mucosa and epithelium. Hypertrophy of the mucosal glands, hyperplasia of blood vessels, and mucosal edema decreased after treatment. These changes were more noticeable in uncinectomy group. Balloon sinuplasty was associated with a higher number of inflammatory cells at 6 months after treatment (P = 0.05).
Level of Evidence
1b. Laryngoscope, 126:2652–2658, 2016 |
| doi_str_mv | 10.1002/lary.26072 |
| format | Article |
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To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy.
Methods
A prospective randomized controlled trial in patients with CRS of the maxillary sinuses without severe pathology of other sinuses. Patients were randomized into two groups: uncinectomy and balloon sinuplasty. The main variables in our study are histopathology of nasal mucosa and expression of metalloproteinase‐9 protein. These parameters were analyzed preoperatively and at 3 months, 6 months, and 12 months postoperatively.
Results
Thickened epithelium, absence of cilia, metaplasia of epithelium, hyperplasia of mucosal glands, angiogenesis, and increased inflammatory cells were observed in the majority of preoperative samples. History of allergy was associated with a higher number of goblet cells, and shedding of epithelium was associated with worse quality of life. A higher number of inflammatory cells were associated with an increased number of goblet cells preoperatively, as well as after treatment. Both treatments resulted in a decrease of inflammation in the mucosa and epithelium. Hypertrophy of the mucosal glands, hyperplasia of blood vessels, and mucosal edema decreased after treatment. These changes were more noticeable in uncinectomy group. Balloon sinuplasty was associated with a higher number of inflammatory cells at 6 months after treatment (P = 0.05).
Level of Evidence
1b. Laryngoscope, 126:2652–2658, 2016</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.26072</identifier><identifier>PMID: 27261416</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; balloon sinuplasty ; Chronic Disease ; Female ; Histopathology ; Humans ; Hypersensitivity - complications ; inflammation ; Inflammation - pathology ; Male ; Mucous membrane ; nasal mucosa ; Nasal Mucosa - pathology ; Nose ; Otorhinolaryngologic Surgical Procedures - methods ; Pathology ; Prospective Studies ; Quality of Life ; Rhinitis ; Rhinitis - complications ; Rhinitis - pathology ; Rhinitis - surgery ; Rhinosinusitis ; Sinusitis ; Sinusitis - complications ; Sinusitis - pathology ; Sinusitis - surgery ; uncinectomy</subject><ispartof>The Laryngoscope, 2016-12, Vol.126 (12), p.2652-2658</ispartof><rights>2016 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3952-50fcd0f0eebd5fd13406da84de71c5c381d2aabf99136a9d358add7d55c1f94f3</citedby><cites>FETCH-LOGICAL-c3952-50fcd0f0eebd5fd13406da84de71c5c381d2aabf99136a9d358add7d55c1f94f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.26072$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.26072$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27261416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bizaki, Argyro J.</creatorcontrib><creatorcontrib>Numminen, Jura</creatorcontrib><creatorcontrib>Taulu, Rami</creatorcontrib><creatorcontrib>Kholova, Ivana</creatorcontrib><creatorcontrib>Rautiainen, Markus</creatorcontrib><title>Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy.
Methods
A prospective randomized controlled trial in patients with CRS of the maxillary sinuses without severe pathology of other sinuses. Patients were randomized into two groups: uncinectomy and balloon sinuplasty. The main variables in our study are histopathology of nasal mucosa and expression of metalloproteinase‐9 protein. These parameters were analyzed preoperatively and at 3 months, 6 months, and 12 months postoperatively.
Results
Thickened epithelium, absence of cilia, metaplasia of epithelium, hyperplasia of mucosal glands, angiogenesis, and increased inflammatory cells were observed in the majority of preoperative samples. History of allergy was associated with a higher number of goblet cells, and shedding of epithelium was associated with worse quality of life. A higher number of inflammatory cells were associated with an increased number of goblet cells preoperatively, as well as after treatment. Both treatments resulted in a decrease of inflammation in the mucosa and epithelium. Hypertrophy of the mucosal glands, hyperplasia of blood vessels, and mucosal edema decreased after treatment. These changes were more noticeable in uncinectomy group. Balloon sinuplasty was associated with a higher number of inflammatory cells at 6 months after treatment (P = 0.05).
Level of Evidence
1b. Laryngoscope, 126:2652–2658, 2016</description><subject>Adult</subject><subject>balloon sinuplasty</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>inflammation</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Mucous membrane</subject><subject>nasal mucosa</subject><subject>Nasal Mucosa - pathology</subject><subject>Nose</subject><subject>Otorhinolaryngologic Surgical Procedures - methods</subject><subject>Pathology</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Rhinitis</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - pathology</subject><subject>Rhinitis - surgery</subject><subject>Rhinosinusitis</subject><subject>Sinusitis</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - pathology</subject><subject>Sinusitis - surgery</subject><subject>uncinectomy</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1rFDEYB_AgFrtWL34AGfAi0ql5mWQmva2LW2uXCqWinkI2L25qJlmTGXT76c24bQ8ePCWQ3_Mn_B8AXiB4giDEb71MuxPMYIsfgRmiBNUN5_QxmJVHUncUfz0ET3O-gRC1hMIn4BC3mKEGsRnYXCcjh96EoYq2ShsXYnZhzG5wuZJBVxuXh7iVwyb6-H03oSCz9FU_qpjlaTWvVAxDit4bfVylMhJ7dzvdlXfBqULzMOrdM3Bgpc_m-d15BD4v318vPtSrT2fni_mqVoRTXFNolYYWGrPW1GpEGsi07BptWqSoIh3SWMq15RwRJrkmtJNat5pShSxvLDkCr_e52xR_jiYPondZGe9lMHHMAnWYMQ550xT66h96E8cUyu-K4i3mBLFJvdkrlWLOyVixTa4vlQsExdS_mPoXf_sv-OVd5LjujX6g94UXgPbgl_Nm958osZpffbsPrfczZRXm98OMTD8Ea0lLxZfLM7G8_Pjuarm4EBfkD3x8oUI</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Bizaki, Argyro J.</creator><creator>Numminen, Jura</creator><creator>Taulu, Rami</creator><creator>Kholova, Ivana</creator><creator>Rautiainen, Markus</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study</title><author>Bizaki, Argyro J. ; Numminen, Jura ; Taulu, Rami ; Kholova, Ivana ; Rautiainen, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3952-50fcd0f0eebd5fd13406da84de71c5c381d2aabf99136a9d358add7d55c1f94f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>balloon sinuplasty</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>inflammation</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Mucous membrane</topic><topic>nasal mucosa</topic><topic>Nasal Mucosa - pathology</topic><topic>Nose</topic><topic>Otorhinolaryngologic Surgical Procedures - methods</topic><topic>Pathology</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Rhinitis</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - pathology</topic><topic>Rhinitis - surgery</topic><topic>Rhinosinusitis</topic><topic>Sinusitis</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - pathology</topic><topic>Sinusitis - surgery</topic><topic>uncinectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bizaki, Argyro J.</creatorcontrib><creatorcontrib>Numminen, Jura</creatorcontrib><creatorcontrib>Taulu, Rami</creatorcontrib><creatorcontrib>Kholova, Ivana</creatorcontrib><creatorcontrib>Rautiainen, Markus</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bizaki, Argyro J.</au><au>Numminen, Jura</au><au>Taulu, Rami</au><au>Kholova, Ivana</au><au>Rautiainen, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2016-12</date><risdate>2016</risdate><volume>126</volume><issue>12</issue><spage>2652</spage><epage>2658</epage><pages>2652-2658</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
To study the pathology of upper airway mucosa, as well as valuate and compare changes in pathology after the treatment of chronic rhinosinusitis (CRS) patients with balloon sinuplasty versus uncinectomy.
Methods
A prospective randomized controlled trial in patients with CRS of the maxillary sinuses without severe pathology of other sinuses. Patients were randomized into two groups: uncinectomy and balloon sinuplasty. The main variables in our study are histopathology of nasal mucosa and expression of metalloproteinase‐9 protein. These parameters were analyzed preoperatively and at 3 months, 6 months, and 12 months postoperatively.
Results
Thickened epithelium, absence of cilia, metaplasia of epithelium, hyperplasia of mucosal glands, angiogenesis, and increased inflammatory cells were observed in the majority of preoperative samples. History of allergy was associated with a higher number of goblet cells, and shedding of epithelium was associated with worse quality of life. A higher number of inflammatory cells were associated with an increased number of goblet cells preoperatively, as well as after treatment. Both treatments resulted in a decrease of inflammation in the mucosa and epithelium. Hypertrophy of the mucosal glands, hyperplasia of blood vessels, and mucosal edema decreased after treatment. These changes were more noticeable in uncinectomy group. Balloon sinuplasty was associated with a higher number of inflammatory cells at 6 months after treatment (P = 0.05).
Level of Evidence
1b. Laryngoscope, 126:2652–2658, 2016</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27261416</pmid><doi>10.1002/lary.26072</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult balloon sinuplasty Chronic Disease Female Histopathology Humans Hypersensitivity - complications inflammation Inflammation - pathology Male Mucous membrane nasal mucosa Nasal Mucosa - pathology Nose Otorhinolaryngologic Surgical Procedures - methods Pathology Prospective Studies Quality of Life Rhinitis Rhinitis - complications Rhinitis - pathology Rhinitis - surgery Rhinosinusitis Sinusitis Sinusitis - complications Sinusitis - pathology Sinusitis - surgery uncinectomy |
| title | Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study |
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