Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors
Summary Background Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age‐m...
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| Veröffentlicht in: | Pediatric pulmonology 2016-12, Vol.51 (12), p.1320-1329 |
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| creator | Bojanić, Katarina Grizelj, Ruža Dilber, Daniel Šarić, Dalibor Vuković, Jurica Pianosi, Paolo T. Driscoll, David J. Weingarten, Toby N. Pritišanac, Ena Schroeder, Darrell R. Sprung, Juraj |
| description | Summary
Background
Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age‐matched controls and whether CPET results among CDH survivors differ according to self‐reported daily activity.
Methods
In one medical center in Croatia, CDH survivors—patients with surgically corrected CDH who were alive at age 5 years—were invited to participate in spirometry and CPET. Values were compared with those of controls matched 2:1 by age and sex for each CDH survivor aged 7 years or older.
Results
Among 27 CDH survivors aged 5–20 years, 13 (48%) had continued symptoms or spirometric evidence of pulmonary disease. Compared with controls (n = 44), survivors (n = 22) had lower peak oxygen consumption (V˙O2 mean [SD], 35.7 [6.9] vs. 45.3 [8.2] ml/kg per min; P |
| doi_str_mv | 10.1002/ppul.23481 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826687239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4268630991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3601-75c8cbab23a58d96c110e5a60811b4056b227a649c68743fb84fe8c2330ecc003</originalsourceid><addsrcrecordid>eNpdkUtLAzEUhYMoWqsbf4AE3LgZzWOSySy1PqFokYobIWQytxqdl0nHx783tdWFq3vhfudwOQehPUqOKCHsuOv66ojxVNE1NKAkzxOS5nIdDVQmRCKV5FtoO4QXQuItp5toi2WMKa7YAD2OjC9dGx3qtjH-C8MneOsC4A78rPW1aSxgF7CHsrdQYtdg2zZP0Li5qXDpTPfszVNt5s7iZ_CNMzj0_t29tz7soI2ZqQLsruYQ3V-cT0dXyfj28np0Mk4sl4QmmbDKFqZg3AhV5tJSSkAYSRSlRUqELBjLjExzK1WW8lmh0hkoyzgnYC0hfIgOl76db996CHNdu2ChqkwDbR80VUxGKeN5RA_-oS9t75v4XaRSkQqeqwW1v6L6ooZSd97VMRz9m1sE6BL4cBV8_d0p0YtG9KIR_dOInkzuxz9b1CRLjQtz-PzTGP-qZcYzoR9uLvXoTJ7eTSdTfcW_AdlLjgw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1845453989</pqid></control><display><type>article</type><title>Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bojanić, Katarina ; Grizelj, Ruža ; Dilber, Daniel ; Šarić, Dalibor ; Vuković, Jurica ; Pianosi, Paolo T. ; Driscoll, David J. ; Weingarten, Toby N. ; Pritišanac, Ena ; Schroeder, Darrell R. ; Sprung, Juraj</creator><creatorcontrib>Bojanić, Katarina ; Grizelj, Ruža ; Dilber, Daniel ; Šarić, Dalibor ; Vuković, Jurica ; Pianosi, Paolo T. ; Driscoll, David J. ; Weingarten, Toby N. ; Pritišanac, Ena ; Schroeder, Darrell R. ; Sprung, Juraj</creatorcontrib><description>Summary
Background
Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age‐matched controls and whether CPET results among CDH survivors differ according to self‐reported daily activity.
Methods
In one medical center in Croatia, CDH survivors—patients with surgically corrected CDH who were alive at age 5 years—were invited to participate in spirometry and CPET. Values were compared with those of controls matched 2:1 by age and sex for each CDH survivor aged 7 years or older.
Results
Among 27 CDH survivors aged 5–20 years, 13 (48%) had continued symptoms or spirometric evidence of pulmonary disease. Compared with controls (n = 44), survivors (n = 22) had lower peak oxygen consumption (V˙O2 mean [SD], 35.7 [6.9] vs. 45.3 [8.2] ml/kg per min; P < 0.001). At peak exercise, V˙O2/heart rate (P < 0.001), tidal volume (P = 0.005), and minute ventilation (P < 0.001) were lower in survivors, but the maximal respiratory rate was not different (P = 0.72). Among survivors, mean (SD) V˙O2peak (ml/kg per min) differed by self‐reported activity level: athletic, 40.3 (5.0); normal, 35.8 (6.5); and sedentary, 32.1 (6.8) (by ANOVA, P = 0.10 across three groups and P = 0.04 athletic vs. sedentary).
Conclusion
More than half of CDH survivors continue to have chronic pulmonary disease. CDH survivors had lower aerobic exercise capacity than controls. Self‐reporting information on daily activities may identify CDH patients with low V˙O2max who may benefit from physical training. Pediatr Pulmonol. 2016;51:1320–1329. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.23481</identifier><identifier>PMID: 27228382</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; cardiopulmonary exercise performance ; cardiopulmonary exercise testing ; Case-Control Studies ; Child ; Child, Preschool ; Chronic Disease ; congenital diaphragmatic hernia ; Croatia ; Exercise ; Exercise Test ; Exercise Tolerance - physiology ; Female ; Heart Rate ; Hernias, Diaphragmatic, Congenital - complications ; Hernias, Diaphragmatic, Congenital - physiopathology ; Hernias, Diaphragmatic, Congenital - surgery ; Humans ; Lung - physiopathology ; Lung Diseases - etiology ; Lung Diseases - physiopathology ; Male ; maximal exercise capacity ; Oxygen Consumption - physiology ; pulmonary function ; Spirometry ; Survivors ; Young Adult</subject><ispartof>Pediatric pulmonology, 2016-12, Vol.51 (12), p.1320-1329</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3601-75c8cbab23a58d96c110e5a60811b4056b227a649c68743fb84fe8c2330ecc003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.23481$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.23481$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27228382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bojanić, Katarina</creatorcontrib><creatorcontrib>Grizelj, Ruža</creatorcontrib><creatorcontrib>Dilber, Daniel</creatorcontrib><creatorcontrib>Šarić, Dalibor</creatorcontrib><creatorcontrib>Vuković, Jurica</creatorcontrib><creatorcontrib>Pianosi, Paolo T.</creatorcontrib><creatorcontrib>Driscoll, David J.</creatorcontrib><creatorcontrib>Weingarten, Toby N.</creatorcontrib><creatorcontrib>Pritišanac, Ena</creatorcontrib><creatorcontrib>Schroeder, Darrell R.</creatorcontrib><creatorcontrib>Sprung, Juraj</creatorcontrib><title>Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Summary
Background
Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age‐matched controls and whether CPET results among CDH survivors differ according to self‐reported daily activity.
Methods
In one medical center in Croatia, CDH survivors—patients with surgically corrected CDH who were alive at age 5 years—were invited to participate in spirometry and CPET. Values were compared with those of controls matched 2:1 by age and sex for each CDH survivor aged 7 years or older.
Results
Among 27 CDH survivors aged 5–20 years, 13 (48%) had continued symptoms or spirometric evidence of pulmonary disease. Compared with controls (n = 44), survivors (n = 22) had lower peak oxygen consumption (V˙O2 mean [SD], 35.7 [6.9] vs. 45.3 [8.2] ml/kg per min; P < 0.001). At peak exercise, V˙O2/heart rate (P < 0.001), tidal volume (P = 0.005), and minute ventilation (P < 0.001) were lower in survivors, but the maximal respiratory rate was not different (P = 0.72). Among survivors, mean (SD) V˙O2peak (ml/kg per min) differed by self‐reported activity level: athletic, 40.3 (5.0); normal, 35.8 (6.5); and sedentary, 32.1 (6.8) (by ANOVA, P = 0.10 across three groups and P = 0.04 athletic vs. sedentary).
Conclusion
More than half of CDH survivors continue to have chronic pulmonary disease. CDH survivors had lower aerobic exercise capacity than controls. Self‐reporting information on daily activities may identify CDH patients with low V˙O2max who may benefit from physical training. Pediatr Pulmonol. 2016;51:1320–1329. © 2016 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>cardiopulmonary exercise performance</subject><subject>cardiopulmonary exercise testing</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>congenital diaphragmatic hernia</subject><subject>Croatia</subject><subject>Exercise</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Hernias, Diaphragmatic, Congenital - complications</subject><subject>Hernias, Diaphragmatic, Congenital - physiopathology</subject><subject>Hernias, Diaphragmatic, Congenital - surgery</subject><subject>Humans</subject><subject>Lung - physiopathology</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - physiopathology</subject><subject>Male</subject><subject>maximal exercise capacity</subject><subject>Oxygen Consumption - physiology</subject><subject>pulmonary function</subject><subject>Spirometry</subject><subject>Survivors</subject><subject>Young Adult</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLAzEUhYMoWqsbf4AE3LgZzWOSySy1PqFokYobIWQytxqdl0nHx783tdWFq3vhfudwOQehPUqOKCHsuOv66ojxVNE1NKAkzxOS5nIdDVQmRCKV5FtoO4QXQuItp5toi2WMKa7YAD2OjC9dGx3qtjH-C8MneOsC4A78rPW1aSxgF7CHsrdQYtdg2zZP0Li5qXDpTPfszVNt5s7iZ_CNMzj0_t29tz7soI2ZqQLsruYQ3V-cT0dXyfj28np0Mk4sl4QmmbDKFqZg3AhV5tJSSkAYSRSlRUqELBjLjExzK1WW8lmh0hkoyzgnYC0hfIgOl76db996CHNdu2ChqkwDbR80VUxGKeN5RA_-oS9t75v4XaRSkQqeqwW1v6L6ooZSd97VMRz9m1sE6BL4cBV8_d0p0YtG9KIR_dOInkzuxz9b1CRLjQtz-PzTGP-qZcYzoR9uLvXoTJ7eTSdTfcW_AdlLjgw</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Bojanić, Katarina</creator><creator>Grizelj, Ruža</creator><creator>Dilber, Daniel</creator><creator>Šarić, Dalibor</creator><creator>Vuković, Jurica</creator><creator>Pianosi, Paolo T.</creator><creator>Driscoll, David J.</creator><creator>Weingarten, Toby N.</creator><creator>Pritišanac, Ena</creator><creator>Schroeder, Darrell R.</creator><creator>Sprung, Juraj</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors</title><author>Bojanić, Katarina ; Grizelj, Ruža ; Dilber, Daniel ; Šarić, Dalibor ; Vuković, Jurica ; Pianosi, Paolo T. ; Driscoll, David J. ; Weingarten, Toby N. ; Pritišanac, Ena ; Schroeder, Darrell R. ; Sprung, Juraj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3601-75c8cbab23a58d96c110e5a60811b4056b227a649c68743fb84fe8c2330ecc003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>cardiopulmonary exercise performance</topic><topic>cardiopulmonary exercise testing</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>congenital diaphragmatic hernia</topic><topic>Croatia</topic><topic>Exercise</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Hernias, Diaphragmatic, Congenital - complications</topic><topic>Hernias, Diaphragmatic, Congenital - physiopathology</topic><topic>Hernias, Diaphragmatic, Congenital - surgery</topic><topic>Humans</topic><topic>Lung - physiopathology</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - physiopathology</topic><topic>Male</topic><topic>maximal exercise capacity</topic><topic>Oxygen Consumption - physiology</topic><topic>pulmonary function</topic><topic>Spirometry</topic><topic>Survivors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bojanić, Katarina</creatorcontrib><creatorcontrib>Grizelj, Ruža</creatorcontrib><creatorcontrib>Dilber, Daniel</creatorcontrib><creatorcontrib>Šarić, Dalibor</creatorcontrib><creatorcontrib>Vuković, Jurica</creatorcontrib><creatorcontrib>Pianosi, Paolo T.</creatorcontrib><creatorcontrib>Driscoll, David J.</creatorcontrib><creatorcontrib>Weingarten, Toby N.</creatorcontrib><creatorcontrib>Pritišanac, Ena</creatorcontrib><creatorcontrib>Schroeder, Darrell R.</creatorcontrib><creatorcontrib>Sprung, Juraj</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bojanić, Katarina</au><au>Grizelj, Ruža</au><au>Dilber, Daniel</au><au>Šarić, Dalibor</au><au>Vuković, Jurica</au><au>Pianosi, Paolo T.</au><au>Driscoll, David J.</au><au>Weingarten, Toby N.</au><au>Pritišanac, Ena</au><au>Schroeder, Darrell R.</au><au>Sprung, Juraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2016-12</date><risdate>2016</risdate><volume>51</volume><issue>12</issue><spage>1320</spage><epage>1329</epage><pages>1320-1329</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Summary
Background
Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether cardiopulmonary exercise testing (CPET) results differ in CDH survivors versus healthy age‐matched controls and whether CPET results among CDH survivors differ according to self‐reported daily activity.
Methods
In one medical center in Croatia, CDH survivors—patients with surgically corrected CDH who were alive at age 5 years—were invited to participate in spirometry and CPET. Values were compared with those of controls matched 2:1 by age and sex for each CDH survivor aged 7 years or older.
Results
Among 27 CDH survivors aged 5–20 years, 13 (48%) had continued symptoms or spirometric evidence of pulmonary disease. Compared with controls (n = 44), survivors (n = 22) had lower peak oxygen consumption (V˙O2 mean [SD], 35.7 [6.9] vs. 45.3 [8.2] ml/kg per min; P < 0.001). At peak exercise, V˙O2/heart rate (P < 0.001), tidal volume (P = 0.005), and minute ventilation (P < 0.001) were lower in survivors, but the maximal respiratory rate was not different (P = 0.72). Among survivors, mean (SD) V˙O2peak (ml/kg per min) differed by self‐reported activity level: athletic, 40.3 (5.0); normal, 35.8 (6.5); and sedentary, 32.1 (6.8) (by ANOVA, P = 0.10 across three groups and P = 0.04 athletic vs. sedentary).
Conclusion
More than half of CDH survivors continue to have chronic pulmonary disease. CDH survivors had lower aerobic exercise capacity than controls. Self‐reporting information on daily activities may identify CDH patients with low V˙O2max who may benefit from physical training. Pediatr Pulmonol. 2016;51:1320–1329. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27228382</pmid><doi>10.1002/ppul.23481</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent cardiopulmonary exercise performance cardiopulmonary exercise testing Case-Control Studies Child Child, Preschool Chronic Disease congenital diaphragmatic hernia Croatia Exercise Exercise Test Exercise Tolerance - physiology Female Heart Rate Hernias, Diaphragmatic, Congenital - complications Hernias, Diaphragmatic, Congenital - physiopathology Hernias, Diaphragmatic, Congenital - surgery Humans Lung - physiopathology Lung Diseases - etiology Lung Diseases - physiopathology Male maximal exercise capacity Oxygen Consumption - physiology pulmonary function Spirometry Survivors Young Adult |
| title | Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors |
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