Impact of tissue T1 on perfusion measurement with arterial spin labeling
Purpose Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1 on CBF quantification using ASL. Methods To locally modify T1, a low dose of manganese (Mn) was intracer...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-04, Vol.77 (4), p.1656-1664 |
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| container_title | Magnetic resonance in medicine |
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| creator | Debacker, Clément S. Daoust, Alexia Köhler, Sascha Voiron, Jérôme Warnking, Jan M. Barbier, Emmanuel L. |
| description | Purpose
Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1 on CBF quantification using ASL.
Methods
To locally modify T1, a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T1 and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T.
Results
Mn reduced the tissue T1 by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single‐compartment model, the use of a single tissue T1 value yielded a mean relative ipsilateral (Mn‐injected) to contralateral (noninjected) CBF difference of −34% in cortex and −22% in striatum tissue. With a T1 map, these values became −7% and +8%, respectively.
Conclusion
A low dose of Mn reduces the tissue T1 without modifying CBF. Heterogeneous T1 impacts the ASL estimate of CBF in a region‐dependent way. In animals, and when T1 modifications exceed the accuracy with which the tissue T1 can be determined, an estimate of tissue T1 should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656–1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine |
| doi_str_mv | 10.1002/mrm.26255 |
| format | Article |
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Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1 on CBF quantification using ASL.
Methods
To locally modify T1, a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T1 and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T.
Results
Mn reduced the tissue T1 by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single‐compartment model, the use of a single tissue T1 value yielded a mean relative ipsilateral (Mn‐injected) to contralateral (noninjected) CBF difference of −34% in cortex and −22% in striatum tissue. With a T1 map, these values became −7% and +8%, respectively.
Conclusion
A low dose of Mn reduces the tissue T1 without modifying CBF. Heterogeneous T1 impacts the ASL estimate of CBF in a region‐dependent way. In animals, and when T1 modifications exceed the accuracy with which the tissue T1 can be determined, an estimate of tissue T1 should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656–1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26255</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>arterial spin labeling ; cerebral blood flow ; manganese ; perfusion ; quantification ; rat</subject><ispartof>Magnetic resonance in medicine, 2017-04, Vol.77 (4), p.1656-1664</ispartof><rights>2016 International Society for Magnetic Resonance in Medicine</rights><rights>2017 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.26255$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.26255$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids></links><search><creatorcontrib>Debacker, Clément S.</creatorcontrib><creatorcontrib>Daoust, Alexia</creatorcontrib><creatorcontrib>Köhler, Sascha</creatorcontrib><creatorcontrib>Voiron, Jérôme</creatorcontrib><creatorcontrib>Warnking, Jan M.</creatorcontrib><creatorcontrib>Barbier, Emmanuel L.</creatorcontrib><title>Impact of tissue T1 on perfusion measurement with arterial spin labeling</title><title>Magnetic resonance in medicine</title><description>Purpose
Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1 on CBF quantification using ASL.
Methods
To locally modify T1, a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T1 and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T.
Results
Mn reduced the tissue T1 by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single‐compartment model, the use of a single tissue T1 value yielded a mean relative ipsilateral (Mn‐injected) to contralateral (noninjected) CBF difference of −34% in cortex and −22% in striatum tissue. With a T1 map, these values became −7% and +8%, respectively.
Conclusion
A low dose of Mn reduces the tissue T1 without modifying CBF. Heterogeneous T1 impacts the ASL estimate of CBF in a region‐dependent way. In animals, and when T1 modifications exceed the accuracy with which the tissue T1 can be determined, an estimate of tissue T1 should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656–1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><subject>arterial spin labeling</subject><subject>cerebral blood flow</subject><subject>manganese</subject><subject>perfusion</subject><subject>quantification</subject><subject>rat</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLAzEUhYMoWKsL_0HAjZtpc-9kHllKUVtoEaSuQzJzqynzMpmh9N87tq5cnbP4OBw-xu5BzEAInNe-nmGKSXLBJpAgRpgoeckmIpMiikHJa3YTwl4IoVQmJ2y5qjtT9Lzd8d6FMBDfAm8b3pHfDcGNrSYTBk81NT0_uP6LG9-Td6bioXMNr4ylyjWft-xqZ6pAd385ZR8vz9vFMlq_va4WT-uogwySyBbSlgaxsFZSnpekyjIpEcosx5iEUUCGUixEZkFCmRJYFASUKYkojI2n7PG82_n2e6DQ69qFgqrKNNQOQUOOaZrHSskRffiH7tvBN-O7kcoSlcYA-UjNz9TBVXTUnXe18UcNQv8K1aNQfRKqN--bU4l_ALKuanE</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Debacker, Clément S.</creator><creator>Daoust, Alexia</creator><creator>Köhler, Sascha</creator><creator>Voiron, Jérôme</creator><creator>Warnking, Jan M.</creator><creator>Barbier, Emmanuel L.</creator><general>Wiley Subscription Services, Inc</general><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Impact of tissue T1 on perfusion measurement with arterial spin labeling</title><author>Debacker, Clément S. ; Daoust, Alexia ; Köhler, Sascha ; Voiron, Jérôme ; Warnking, Jan M. ; Barbier, Emmanuel L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1715-bc4bda22cbb4e88de9dd5d21d7823e0a91eae62c07b141d6e1b20e1e794220ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>arterial spin labeling</topic><topic>cerebral blood flow</topic><topic>manganese</topic><topic>perfusion</topic><topic>quantification</topic><topic>rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debacker, Clément S.</creatorcontrib><creatorcontrib>Daoust, Alexia</creatorcontrib><creatorcontrib>Köhler, Sascha</creatorcontrib><creatorcontrib>Voiron, Jérôme</creatorcontrib><creatorcontrib>Warnking, Jan M.</creatorcontrib><creatorcontrib>Barbier, Emmanuel L.</creatorcontrib><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Debacker, Clément S.</au><au>Daoust, Alexia</au><au>Köhler, Sascha</au><au>Voiron, Jérôme</au><au>Warnking, Jan M.</au><au>Barbier, Emmanuel L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of tissue T1 on perfusion measurement with arterial spin labeling</atitle><jtitle>Magnetic resonance in medicine</jtitle><date>2017-04</date><risdate>2017</risdate><volume>77</volume><issue>4</issue><spage>1656</spage><epage>1664</epage><pages>1656-1664</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Purpose
Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T1 on CBF quantification using ASL.
Methods
To locally modify T1, a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T1 and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T.
Results
Mn reduced the tissue T1 by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single‐compartment model, the use of a single tissue T1 value yielded a mean relative ipsilateral (Mn‐injected) to contralateral (noninjected) CBF difference of −34% in cortex and −22% in striatum tissue. With a T1 map, these values became −7% and +8%, respectively.
Conclusion
A low dose of Mn reduces the tissue T1 without modifying CBF. Heterogeneous T1 impacts the ASL estimate of CBF in a region‐dependent way. In animals, and when T1 modifications exceed the accuracy with which the tissue T1 can be determined, an estimate of tissue T1 should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656–1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/mrm.26255</doi><tpages>9</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2017-04, Vol.77 (4), p.1656-1664 |
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| language | eng |
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| subjects | arterial spin labeling cerebral blood flow manganese perfusion quantification rat |
| title | Impact of tissue T1 on perfusion measurement with arterial spin labeling |
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