Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice

Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin...

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Veröffentlicht in:	Molecular neurobiology 2017-07, Vol.54 (5), p.3465-3475
Hauptverfasser:	Lima, Leandro Ceotto Freitas, Saliba, Soraya Wilke, Andrade, João Marcus Oliveira, Cunha, Maria Luisa, Cassini-Vieira, Puebla, Feltenberger, John David, Barcelos, Lucíola Silva, Guimarães, André Luiz Sena, de-Paula, Alfredo Mauricio Batista, de Oliveira, Antônio Carlos Pinheiro, Santos, Sérgio Henrique Sousa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animals Biomedical and Life Sciences Biomedicine Body Composition - drug effects Body fat Body Weight - drug effects Body weight gain Cell Biology Corpus Striatum - drug effects Corpus Striatum - pathology Diet Diet, High-Fat Epidemics Excitotoxicity High fat diet Impairment Insulin Male Metabolic Networks and Pathways - drug effects Metabolic pathways Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - metabolism Metabolism Metabolome - drug effects Mice Mice, Obese Models, Biological Motor Activity - drug effects Motor task performance Neostriatum Nerve Degeneration - metabolism Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neurosciences Obesity Quinolinic acid Quinolinic Acid - pharmacology Rodents Rotarod Performance Test Signal transduction Signal Transduction - drug effects Sirtuin 1 - metabolism Stereotaxic surgery Surgery
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