Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect

Abstract Background and Aims: Crohn’s disease [CD] is a complex disorder characterised by an inappropriate immune response, impaired barrier function and microbial dysbiosis. Mutations in nucleotide oligomeriation domain 2 [NOD2] are CD risk factors. Increase of intestinal permeability, CD4+ T cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Crohn's and colitis 2016-12, Vol.10 (12), p.1428-1436
Hauptverfasser:	Al Nabhani, Ziad, Lepage, Patricia, Mauny, Pascal, Montcuquet, Nicolas, Roy, Maryline, Le Roux, Karine, Dussaillant, Monique, Berrebi, Dominique, Hugot, Jean-Pierre, Barreau, Frédérick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - metabolism Dysbiosis - physiopathology Female Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - physiopathology Mice Mice, Inbred C57BL Mice, Knockout Mucins - metabolism Nod2 Signaling Adaptor Protein - deficiency Nod2 Signaling Adaptor Protein - physiology Peyer's Patches - physiopathology Real-Time Polymerase Chain Reaction RNA, Ribosomal, 16S - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!