Pravastatin Effects on Placental Prosurvival Molecular Pathways in a Mouse Model of Preeclampsia

Objective: Using an animal model of preeclampsia induced by overexpression of soluble fms-like tyrosine kinase 1 (sFlt-1), we previously showed that pravastatin prevents the development of a preeclampsia phenotype. Our objective is to determine whether pravastatin treatment may be explained by its e...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2016-11, Vol.23 (11), p.1593-1599
Hauptverfasser:	Saad, Antonio F., Diken, Zaid M., Kechichian, Talar B., Clark, Shannon M., Olson, Gayle L., Saade, George R., Costantine, Maged M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Disease Models, Animal Embryology Female HSP27 Heat-Shock Proteins - metabolism MAP Kinase Signaling System - drug effects Medicine & Public Health Mice Obstetrics/Perinatology/Midwifery Original Article Phosphorylation Placenta - drug effects Placenta - metabolism Pravastatin - administration & dosage Pre-Eclampsia - metabolism Pre-Eclampsia - prevention & control Pregnancy Reproductive Medicine STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism
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