Pathogenesis of alcoholic liver disease
Alcoholic liver disease (ALD) has become one of the most critical health problems in many countries, including Japan. Liver injury in ALD ranges from steatosis and steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Many factors are thought to contribute to the development and prog...
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| Veröffentlicht in: | Hepatology research 2017-01, Vol.47 (1), p.70-79 |
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| container_title | Hepatology research |
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| creator | Sugimoto, Kazushi Takei, Yoshiyuki |
| description | Alcoholic liver disease (ALD) has become one of the most critical health problems in many countries, including Japan. Liver injury in ALD ranges from steatosis and steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Many factors are thought to contribute to the development and progression of ALD, particularly insulin resistance, generation of reactive oxygen species during alcohol metabolism, adipokines from visceral adipose tissue, and endotoxin derived from the gut. Although the pathogenesis of ALD has been widely investigated, the precise mechanisms are yet to be elucidated and many questions remain. This article reviews the possible mechanisms for the development of ALD identified to date. |
| doi_str_mv | 10.1111/hepr.12736 |
| format | Article |
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Liver injury in ALD ranges from steatosis and steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Many factors are thought to contribute to the development and progression of ALD, particularly insulin resistance, generation of reactive oxygen species during alcohol metabolism, adipokines from visceral adipose tissue, and endotoxin derived from the gut. Although the pathogenesis of ALD has been widely investigated, the precise mechanisms are yet to be elucidated and many questions remain. This article reviews the possible mechanisms for the development of ALD identified to date.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12736</identifier><identifier>PMID: 27138729</identifier><language>eng</language><publisher>Netherlands: Wiley Subscription Services, Inc</publisher><subject>adipokine ; Adipose tissue ; alcohol ; Cirrhosis ; cytochrome P450 ; epigenetic change ; Fibrosis ; Hepatocellular carcinoma ; Insulin ; Liver cirrhosis ; Liver diseases ; oxidative stress, intestinal bacterial flora ; Pathogenesis ; Reactive oxygen species ; Steatosis</subject><ispartof>Hepatology research, 2017-01, Vol.47 (1), p.70-79</ispartof><rights>2016 The Japan Society of Hepatology</rights><rights>2016 The Japan Society of Hepatology.</rights><rights>2017 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4476-398b7a913bb5bdaf4556fffec6db2850c4fc0bafa05c018ad6398349853f2c73</citedby><cites>FETCH-LOGICAL-c4476-398b7a913bb5bdaf4556fffec6db2850c4fc0bafa05c018ad6398349853f2c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.12736$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.12736$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27138729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugimoto, Kazushi</creatorcontrib><creatorcontrib>Takei, Yoshiyuki</creatorcontrib><title>Pathogenesis of alcoholic liver disease</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Alcoholic liver disease (ALD) has become one of the most critical health problems in many countries, including Japan. 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This article reviews the possible mechanisms for the development of ALD identified to date.</description><subject>adipokine</subject><subject>Adipose tissue</subject><subject>alcohol</subject><subject>Cirrhosis</subject><subject>cytochrome P450</subject><subject>epigenetic change</subject><subject>Fibrosis</subject><subject>Hepatocellular carcinoma</subject><subject>Insulin</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>oxidative stress, intestinal bacterial flora</subject><subject>Pathogenesis</subject><subject>Reactive oxygen species</subject><subject>Steatosis</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoVqsXf4AseFCErflO9iilWqFgkR68hWw2sVu2TU26Sv-9qVs9eHAuMzDPPAwvABcIDlCqu7ldhwHCgvADcIKkwDkk9PUwzUTynBPKe-A0xgWESEBMj0EPi7QSuDgB11O9mfs3u7Kxjpl3mW6Mn_umNllTf9iQVXW0OtozcOR0E-35vvfB7GE0G47zyfPj0_B-khtKBc9JIUuhC0TKkpWVdpQx7pyzhlcllgwa6gwstdOQGYikrni6ILSQjDhsBOmDm067Dv69tXGjlnU0tmn0yvo2KiQx54JgSBJ69Qdd-Das0nMKFRgyVoiCJuq2o0zwMQbr1DrUSx22CkG1S0_t0lPf6SX4cq9sy6WtftGfuBKAOuCzbuz2H5Uaj6YvnfQLB9t4kw</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Sugimoto, Kazushi</creator><creator>Takei, Yoshiyuki</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Pathogenesis of alcoholic liver disease</title><author>Sugimoto, Kazushi ; Takei, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4476-398b7a913bb5bdaf4556fffec6db2850c4fc0bafa05c018ad6398349853f2c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>adipokine</topic><topic>Adipose tissue</topic><topic>alcohol</topic><topic>Cirrhosis</topic><topic>cytochrome P450</topic><topic>epigenetic change</topic><topic>Fibrosis</topic><topic>Hepatocellular carcinoma</topic><topic>Insulin</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>oxidative stress, intestinal bacterial flora</topic><topic>Pathogenesis</topic><topic>Reactive oxygen species</topic><topic>Steatosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugimoto, Kazushi</creatorcontrib><creatorcontrib>Takei, Yoshiyuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugimoto, Kazushi</au><au>Takei, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenesis of alcoholic liver disease</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2017-01</date><risdate>2017</risdate><volume>47</volume><issue>1</issue><spage>70</spage><epage>79</epage><pages>70-79</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Alcoholic liver disease (ALD) has become one of the most critical health problems in many countries, including Japan. 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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | adipokine Adipose tissue alcohol Cirrhosis cytochrome P450 epigenetic change Fibrosis Hepatocellular carcinoma Insulin Liver cirrhosis Liver diseases oxidative stress, intestinal bacterial flora Pathogenesis Reactive oxygen species Steatosis |
| title | Pathogenesis of alcoholic liver disease |
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