CYP gene expressions in obesity-associated metabolic syndrome

Summary Purpose The contribution of cytochrome P450 ( CYP ) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. Methods A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. Results We observed marked suppressions in CYP2A6 ( p = 0.0123), CYP4F2 ( p = 0.0005), CYP3A5 ( p = 0.0003), and CYP17A1 ( p < 0.0001) gene expressions in MetS patients. Conclusions This is the first study to provide evidence that depressed expressions of CYP2A6 , CYP4F2 , CYP3A5 , and CYP17A1 genes may play a role in MetS.