Recruitment of osteogenic cells to bone formation sites during development and fracture repair
Recruitment of osteoblast lineage cells to their bone-forming locations is essential for skeletal development and fracture healing. In developing bones, osteoprogenitor cells invade the cartilage mold to establish the primary ossification center. Similarly, osteogenic cells infiltrate and populate t...
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| Veröffentlicht in: | Zeitschrift für Rheumatologie 2017-03, Vol.76 (Suppl 1), p.5-9 |
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| container_issue | Suppl 1 |
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| container_title | Zeitschrift für Rheumatologie |
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| creator | Böhm, A.-M. Dirckx, N. Maes, C. |
| description | Recruitment of osteoblast lineage cells to their bone-forming locations is essential for skeletal development and fracture healing. In developing bones, osteoprogenitor cells invade the cartilage mold to establish the primary ossification center. Similarly, osteogenic cells infiltrate and populate the callus tissue that is formed following an injury. Proper bone development and successful fracture repair must, therefore, rely on controlled temporal and spatial navigation cues guiding the cells to the sites where new bone formation is needed. Some cellular mechanisms and molecular pathways involved have been elucidated. |
| doi_str_mv | 10.1007/s00393-015-1574-5 |
| format | Article |
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| subjects | Immunology Internal Medicine Laboratory Medicine Medicine Medicine & Public Health Neues aus der Forschung Orthopedics Rheumatology |
| title | Recruitment of osteogenic cells to bone formation sites during development and fracture repair |
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