In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion
Objectives The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion. Material and methods A three-way crossover study of 7 days was conducted invol...
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| Veröffentlicht in: | Clinical oral investigations 2017, Vol.21 (1), p.339-346 |
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| creator | de Oliveira, Andressa Feitosa Bezerra de Oliveira Diniz, Luciana Vilar Forte, Franklin Delano Soares Sampaio, Fabio Correia Ccahuana-Vásquez, Renzo Alberto Tochukwu Amaechi, Bennett |
| description | Objectives
The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion.
Material and methods
A three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva—no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey’s test were used with a
p
0.05).
Conclusions
It is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface.
Clinical relevance
The CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel. |
| doi_str_mv | 10.1007/s00784-016-1796-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826668218</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826668218</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8584e0eebff678d6f9f68f4191bf8baf1a53af25232b92f33d79269d13f8abc53</originalsourceid><addsrcrecordid>eNp1kE1PxCAQhonR-P0DvBgSL16qDLRAj2bjxyYm7kEPnghth92abVFos_Hfy7pqjImXATLPvMBDyAmwC2BMXcZUdJ4xkBmoMpUtsg-5kJlQCrY_9zyTpYY9chDjC2OQSyV2yR5XjLMS-D55nvY0tsNI0TmsB-odtXQym2VXkxmtF7hq-zmdjx31PcXedrikGHxs09HG6OvWDthQH2jvB7pqhwW1VbDr_hHZcXYZ8fhrPSRPN9ePk7vs_uF2Orm6z2qh-JDpQufIECvnpNKNdKWT2uVQQuV0ZR3YQljHCy54VXInRKNKLssGhNO2qgtxSM43ua_Bv40YB9O1scbl0vbox2hAcyml5qATevYHffFj6NPrElXkQmv5ScGGqtNHY0BnXkPb2fBugJm1d7PxbpJ3s_ZuIM2cfiWPVYfNz8S36ATwDRBTq59j-HX1v6kfjveL7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1854388618</pqid></control><display><type>article</type><title>In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>de Oliveira, Andressa Feitosa Bezerra ; de Oliveira Diniz, Luciana Vilar ; Forte, Franklin Delano Soares ; Sampaio, Fabio Correia ; Ccahuana-Vásquez, Renzo Alberto ; Tochukwu Amaechi, Bennett</creator><creatorcontrib>de Oliveira, Andressa Feitosa Bezerra ; de Oliveira Diniz, Luciana Vilar ; Forte, Franklin Delano Soares ; Sampaio, Fabio Correia ; Ccahuana-Vásquez, Renzo Alberto ; Tochukwu Amaechi, Bennett</creatorcontrib><description>Objectives
The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion.
Material and methods
A three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva—no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey’s test were used with a
p
< 0.05.
Results
The enamel depth and the enamel surface roughness of the CPP-ACP gum group were significantly lower than the others (ANOVA,
p
< 0.05). No significant differences were observed between the treatments when associated with abrasion (
p
> 0.05). A positive and significant correlation was seen between the lesion depth and enamel surface roughness for GI (
r
= 0.87,
p
= 0.00) and GIII (
r
= 0.79,
p
= 0.00) groups. The estimated total calcium presented in the saliva after the chewed CPP-ACP gum showed no statistical significance between the mean absorbance values at the different time collections (
p
> 0.05).
Conclusions
It is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface.
Clinical relevance
The CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-016-1796-1</identifier><identifier>PMID: 27020912</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Caseins - pharmacology ; Chewing Gum ; Cross-Over Studies ; Dentistry ; Double-Blind Method ; Female ; Humans ; Male ; Medicine ; Original Article ; Surface Properties ; Tooth Abrasion - complications ; Tooth Erosion - etiology ; Tooth Erosion - prevention & control ; Treatment Outcome</subject><ispartof>Clinical oral investigations, 2017, Vol.21 (1), p.339-346</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Clinical Oral Investigations is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8584e0eebff678d6f9f68f4191bf8baf1a53af25232b92f33d79269d13f8abc53</citedby><cites>FETCH-LOGICAL-c372t-8584e0eebff678d6f9f68f4191bf8baf1a53af25232b92f33d79269d13f8abc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-016-1796-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-016-1796-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27020912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira, Andressa Feitosa Bezerra</creatorcontrib><creatorcontrib>de Oliveira Diniz, Luciana Vilar</creatorcontrib><creatorcontrib>Forte, Franklin Delano Soares</creatorcontrib><creatorcontrib>Sampaio, Fabio Correia</creatorcontrib><creatorcontrib>Ccahuana-Vásquez, Renzo Alberto</creatorcontrib><creatorcontrib>Tochukwu Amaechi, Bennett</creatorcontrib><title>In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion.
Material and methods
A three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva—no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey’s test were used with a
p
< 0.05.
Results
The enamel depth and the enamel surface roughness of the CPP-ACP gum group were significantly lower than the others (ANOVA,
p
< 0.05). No significant differences were observed between the treatments when associated with abrasion (
p
> 0.05). A positive and significant correlation was seen between the lesion depth and enamel surface roughness for GI (
r
= 0.87,
p
= 0.00) and GIII (
r
= 0.79,
p
= 0.00) groups. The estimated total calcium presented in the saliva after the chewed CPP-ACP gum showed no statistical significance between the mean absorbance values at the different time collections (
p
> 0.05).
Conclusions
It is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface.
Clinical relevance
The CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel.</description><subject>Adult</subject><subject>Caseins - pharmacology</subject><subject>Chewing Gum</subject><subject>Cross-Over Studies</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Original Article</subject><subject>Surface Properties</subject><subject>Tooth Abrasion - complications</subject><subject>Tooth Erosion - etiology</subject><subject>Tooth Erosion - prevention & control</subject><subject>Treatment Outcome</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1PxCAQhonR-P0DvBgSL16qDLRAj2bjxyYm7kEPnghth92abVFos_Hfy7pqjImXATLPvMBDyAmwC2BMXcZUdJ4xkBmoMpUtsg-5kJlQCrY_9zyTpYY9chDjC2OQSyV2yR5XjLMS-D55nvY0tsNI0TmsB-odtXQym2VXkxmtF7hq-zmdjx31PcXedrikGHxs09HG6OvWDthQH2jvB7pqhwW1VbDr_hHZcXYZ8fhrPSRPN9ePk7vs_uF2Orm6z2qh-JDpQufIECvnpNKNdKWT2uVQQuV0ZR3YQljHCy54VXInRKNKLssGhNO2qgtxSM43ua_Bv40YB9O1scbl0vbox2hAcyml5qATevYHffFj6NPrElXkQmv5ScGGqtNHY0BnXkPb2fBugJm1d7PxbpJ3s_ZuIM2cfiWPVYfNz8S36ATwDRBTq59j-HX1v6kfjveL7g</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>de Oliveira, Andressa Feitosa Bezerra</creator><creator>de Oliveira Diniz, Luciana Vilar</creator><creator>Forte, Franklin Delano Soares</creator><creator>Sampaio, Fabio Correia</creator><creator>Ccahuana-Vásquez, Renzo Alberto</creator><creator>Tochukwu Amaechi, Bennett</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion</title><author>de Oliveira, Andressa Feitosa Bezerra ; de Oliveira Diniz, Luciana Vilar ; Forte, Franklin Delano Soares ; Sampaio, Fabio Correia ; Ccahuana-Vásquez, Renzo Alberto ; Tochukwu Amaechi, Bennett</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8584e0eebff678d6f9f68f4191bf8baf1a53af25232b92f33d79269d13f8abc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Caseins - pharmacology</topic><topic>Chewing Gum</topic><topic>Cross-Over Studies</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Original Article</topic><topic>Surface Properties</topic><topic>Tooth Abrasion - complications</topic><topic>Tooth Erosion - etiology</topic><topic>Tooth Erosion - prevention & control</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, Andressa Feitosa Bezerra</creatorcontrib><creatorcontrib>de Oliveira Diniz, Luciana Vilar</creatorcontrib><creatorcontrib>Forte, Franklin Delano Soares</creatorcontrib><creatorcontrib>Sampaio, Fabio Correia</creatorcontrib><creatorcontrib>Ccahuana-Vásquez, Renzo Alberto</creatorcontrib><creatorcontrib>Tochukwu Amaechi, Bennett</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Andressa Feitosa Bezerra</au><au>de Oliveira Diniz, Luciana Vilar</au><au>Forte, Franklin Delano Soares</au><au>Sampaio, Fabio Correia</au><au>Ccahuana-Vásquez, Renzo Alberto</au><au>Tochukwu Amaechi, Bennett</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2017</date><risdate>2017</risdate><volume>21</volume><issue>1</issue><spage>339</spage><epage>346</epage><pages>339-346</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion.
Material and methods
A three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva—no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey’s test were used with a
p
< 0.05.
Results
The enamel depth and the enamel surface roughness of the CPP-ACP gum group were significantly lower than the others (ANOVA,
p
< 0.05). No significant differences were observed between the treatments when associated with abrasion (
p
> 0.05). A positive and significant correlation was seen between the lesion depth and enamel surface roughness for GI (
r
= 0.87,
p
= 0.00) and GIII (
r
= 0.79,
p
= 0.00) groups. The estimated total calcium presented in the saliva after the chewed CPP-ACP gum showed no statistical significance between the mean absorbance values at the different time collections (
p
> 0.05).
Conclusions
It is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface.
Clinical relevance
The CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27020912</pmid><doi>10.1007/s00784-016-1796-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2017, Vol.21 (1), p.339-346 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1826668218 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Caseins - pharmacology Chewing Gum Cross-Over Studies Dentistry Double-Blind Method Female Humans Male Medicine Original Article Surface Properties Tooth Abrasion - complications Tooth Erosion - etiology Tooth Erosion - prevention & control Treatment Outcome |
| title | In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion |
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