Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: a probable linkage between obesity and coronary arterial disease

Obesity is positively related to the growing prevalence of coronary arterial disease (CAD). It is well established in terms of the plasma concentrations of free fatty acid (FFA) that are up-regulated in cases associating with obesity. Oleic acid (OA) is known as the most abundant monounsaturated fat...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2016-10, Vol.160 (4), p.217-225
Hauptverfasser:	Chan, Shih-Hung, Chu, Pei-Ming, Kao, Chung-Lan, Cheng, Yung-Hsin, Hung, Ching-Hsia, Tsai, Kun-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Gene Expression Regulation, Enzymologic Humans Matrix Metalloproteinase 1 - biosynthesis Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 3 - biosynthesis Matrix Metalloproteinase 3 - genetics Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Obesity - genetics Obesity - metabolism Obesity - pathology Oleic Acid - genetics Oleic Acid - metabolism PPAR gamma - biosynthesis PPAR gamma - genetics Sirtuin 1 - biosynthesis Sirtuin 1 - genetics Up-Regulation
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