αvß3-Integrin–Targeted Magnetic Resonance Imaging for the Assessment of Early Antiangiogenic Therapy Effects in Orthotopic Breast Cancer Xenografts

OBJECTIVESThe aim of this study was to investigate magnetic resonance imaging (MRI) with αvß3-integrin–targeted ultrasmall superparamagnetic iron oxide nanoparticles (RGD-USPIO) for the in vivo monitoring of early antiangiogenic therapy effects in experimental breast cancer. MATERIALS AND METHODSOrt...

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Veröffentlicht in:	Investigative radiology 2016-11, Vol.51 (11), p.746-755
Hauptverfasser:	Kazmierczak, Philipp Maximilian, Schneider, Moritz, Habereder, Thomas, Hirner-Eppeneder, Heidrun, Eschbach, Ralf S, Moser, Matthias, Reiser, Maximilian F, Lauber, Kirsten, Nikolaou, Konstantin, Cyran, Clemens C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Animals Bevacizumab - therapeutic use Breast Neoplasms - drug therapy Contrast Media Dextrans Disease Models, Animal Female Heterografts Humans Integrin alphaVbeta3 Magnetic Resonance Imaging - methods Magnetite Nanoparticles Mice Treatment Outcome
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