Recent updates on GPCR biased agonism

[Display omitted] G protein-coupled receptors (GPCRs) are the most important targets for drug discovery and not surprisingly ∼40% of all drugs currently in the market act on these receptors. Currently, one of the most active areas in GPCRs signaling is biased agonism, a phenomenon that occurs when a...

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Veröffentlicht in:	Pharmacological research 2016-10, Vol.112, p.49-57
Hauptverfasser:	Pupo, André S., Duarte, Diego A., Lima, Vanessa, Teixeira, Larissa B., Parreiras-e-Silva, Lucas T., Costa-Neto, Claudio M.
Format:	Artikel
Sprache:	eng
Schlagworte:	7TMR Allosteric Site Animals Binding Sites Drug Discovery Functional selectivity GPCR Humans Ligands Molecular Targeted Therapy Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Signal Transduction
Online-Zugang:	Volltext
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