Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

Extracellular signal-regulated kinase (ERK) has been implicated in the development of insulin resistance associated with obesity and type 2 diabetes mellitus. We have now examined the potential of pharmacological targeting of the ERK pathway with MEK (ERK kinase) inhibitors (PD184352 and PD0325901)...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2016-04, Vol.310 (8), p.E643-E651
Hauptverfasser:	Ozaki, Kei-Ichi, Awazu, Midori, Tamiya, Mayuko, Iwasaki, Yuka, Harada, Aya, Kugisaki, Satomi, Tanimura, Susumu, Kohno, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Adipokines - metabolism Adiponectin - metabolism Animals Benzamides - pharmacology Blood Glucose - drug effects Blood Glucose - metabolism Chemokine CCL2 - drug effects Chemokine CCL2 - metabolism Diabetes Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat Diphenylamine - analogs & derivatives Diphenylamine - pharmacology Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Fatty Acids, Nonesterified - metabolism Glucose Tolerance Test Hyperlipidemias - metabolism Immunoblotting In Vitro Techniques Insulin - metabolism Insulin Resistance Interleukin-6 - metabolism Lipolysis - drug effects Male MAP Kinase Signaling System - drug effects Mice Obesity Pathogenesis Protein Kinase Inhibitors - pharmacology Real-Time Polymerase Chain Reaction Receptors, Leptin - deficiency Reverse Transcriptase Polymerase Chain Reaction Rodents Signal Transduction Tissues Triglycerides - metabolism Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism
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