Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes
Abstract Purpose The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs o...
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| Veröffentlicht in: | Surgical oncology 2016-12, Vol.25 (4), p.449-456 |
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| creator | Monahan, Denise A Wang, Jun Lee, Oukseub Revesz, Elizabeth Taft, Nancy Ivancic, David Hansen, Nora M Bethke, Kevin P Zalles, C Khan, Seema A |
| description | Abstract Purpose The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs of newly diagnosed breast cancer patients. Methods 83 women underwent rFNA of the CUB. Cytologic analysis was performed using the Masood Score (MS), atypia was defined as MS > 14. RNA was extracted using 80% of the sample. The expression of 20 hormone related genes was quantified using Taqman Low Density Arrays. Statistical analysis was performed using 2-tailed t tests and linear regression. Results Cytological atypia was more frequent in multiparous women (P = 0.0392), and was not associated with any tumor-related features in the affected breast. Masood Score was higher with shorter interval since last pregnancy (R = 0.204, P = 0.0417), higher number of births (R = 0.369, P = 0.0006), and estrogen receptor (ER) negativity of the index cancer (R = −0.203, P = 0.065). Individual cytologic features were associated with aspects of parity. Specifically, anisonucleosis was correlated with shorter interval since last pregnancy (R = 0.318, P = 0.0201), higher number of births (R = 0.382, P = 0.0004), and ER status (R = −0.314, P = 0.0038). Eight estrogen-regulated genes were increased in atypical samples (P |
| doi_str_mv | 10.1016/j.suronc.2015.12.001 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826659659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0960740415300384</els_id><sourcerecordid>4273577161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-57c544b0c5ccfa9c2aae49679fb7f9f3df29914f34c6665f4a547f2d8df94463</originalsourceid><addsrcrecordid>eNqFkk2LHCEQhiVkyU42-QchCLnk0r1q29peAmHIFyzsIXsXxy4nTnp0ovZC__u1md0E9hIQFep5y7LeQugdJS0lVFwf2jynGGzLCO1bylpC6Au0oYNUTdcx8hJtiBKkkZzwS_Q65wMhREhGX6FLJoZeSEk3aL9dSpzi3ltsynLyBvuAyy_ANoaSzGQK1B3PwTgHtsCIdwlMLthnnGANj7hEfDLJlwWbMGLIJcU9hOYpXO-Q36ALZ6YMbx_PK3T39cvd9ntzc_vtx_bzTWM570vTS9tzviO2t9YZZZkxwJWQyu2kU64bHVOKctdxK4ToHTc9l46Nw-gU56K7Qh_PaU8p_plrKfros4VpMgHinDUdWJWpuir64Rl6iHMKtbhKcck7QZWsFD9TNsWcEzh9Sv5o0qIp0asP-qDPPujVB02Zrj5U2fvH5PPuCONf0VPjK_DpDEBtxr2HpLP1ECyMPtU-6zH6_73wPIGdfPDWTL9hgfzvLzpXgf65zsI6CrTvCOkG3j0ASBGxEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1847436197</pqid></control><display><type>article</type><title>Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Monahan, Denise A ; Wang, Jun ; Lee, Oukseub ; Revesz, Elizabeth ; Taft, Nancy ; Ivancic, David ; Hansen, Nora M ; Bethke, Kevin P ; Zalles, C ; Khan, Seema A</creator><creatorcontrib>Monahan, Denise A ; Wang, Jun ; Lee, Oukseub ; Revesz, Elizabeth ; Taft, Nancy ; Ivancic, David ; Hansen, Nora M ; Bethke, Kevin P ; Zalles, C ; Khan, Seema A</creatorcontrib><description>Abstract Purpose The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs of newly diagnosed breast cancer patients. Methods 83 women underwent rFNA of the CUB. Cytologic analysis was performed using the Masood Score (MS), atypia was defined as MS > 14. RNA was extracted using 80% of the sample. The expression of 20 hormone related genes was quantified using Taqman Low Density Arrays. Statistical analysis was performed using 2-tailed t tests and linear regression. Results Cytological atypia was more frequent in multiparous women (P = 0.0392), and was not associated with any tumor-related features in the affected breast. Masood Score was higher with shorter interval since last pregnancy (R = 0.204, P = 0.0417), higher number of births (R = 0.369, P = 0.0006), and estrogen receptor (ER) negativity of the index cancer (R = −0.203, P = 0.065). Individual cytologic features were associated with aspects of parity. Specifically, anisonucleosis was correlated with shorter interval since last pregnancy (R = 0.318, P = 0.0201), higher number of births (R = 0.382, P = 0.0004), and ER status (R = −0.314, P = 0.0038). Eight estrogen-regulated genes were increased in atypical samples (P < 0.005), including TFF1, AGT, PDZK1, PGR, GREB1, PRLR, CAMK2B, and CCND1. Conclusions Cytologic atypia, and particularly anisonucleosis, is associated with recent and multiple births and ER negative status of the index tumor. Atypical samples showed increased expression of estrogen-related genes, consistent with the role of estrogen exposure in breast cancer development.</description><identifier>ISSN: 0960-7404</identifier><identifier>EISSN: 1879-3320</identifier><identifier>DOI: 10.1016/j.suronc.2015.12.001</identifier><identifier>PMID: 26856771</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Anisonucleosis ; Biomarkers, Tumor - genetics ; Biopsy, Fine-Needle ; Breast - cytology ; Breast - metabolism ; Breast cancer ; Breast cancer risk ; Breast Neoplasms - diagnosis ; Breast Neoplasms - genetics ; Breast Neoplasms - surgery ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - surgery ; Carcinoma, Lobular - diagnosis ; Carcinoma, Lobular - genetics ; Carcinoma, Lobular - surgery ; Case-Control Studies ; Contralateral unaffected breast ; Cytologic atypia ; Estrogens ; Estrogens - metabolism ; Female ; Follow-Up Studies ; Gene expression ; Gene Expression Profiling ; Genomics ; Health risk assessment ; Hematology, Oncology and Palliative Medicine ; Histology ; Humans ; Hypotheses ; Kinases ; Mastectomy ; Middle Aged ; Neoplasm Grading ; Parity ; Pregnancy ; Prognosis ; Proteins ; Random fine needle aspiration ; Receptors, Estrogen - genetics ; Receptors, Progesterone - genetics ; Signal Transduction ; Surgery</subject><ispartof>Surgical oncology, 2016-12, Vol.25 (4), p.449-456</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-57c544b0c5ccfa9c2aae49679fb7f9f3df29914f34c6665f4a547f2d8df94463</citedby><cites>FETCH-LOGICAL-c445t-57c544b0c5ccfa9c2aae49679fb7f9f3df29914f34c6665f4a547f2d8df94463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.suronc.2015.12.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26856771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monahan, Denise A</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Lee, Oukseub</creatorcontrib><creatorcontrib>Revesz, Elizabeth</creatorcontrib><creatorcontrib>Taft, Nancy</creatorcontrib><creatorcontrib>Ivancic, David</creatorcontrib><creatorcontrib>Hansen, Nora M</creatorcontrib><creatorcontrib>Bethke, Kevin P</creatorcontrib><creatorcontrib>Zalles, C</creatorcontrib><creatorcontrib>Khan, Seema A</creatorcontrib><title>Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes</title><title>Surgical oncology</title><addtitle>Surg Oncol</addtitle><description>Abstract Purpose The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs of newly diagnosed breast cancer patients. Methods 83 women underwent rFNA of the CUB. Cytologic analysis was performed using the Masood Score (MS), atypia was defined as MS > 14. RNA was extracted using 80% of the sample. The expression of 20 hormone related genes was quantified using Taqman Low Density Arrays. Statistical analysis was performed using 2-tailed t tests and linear regression. Results Cytological atypia was more frequent in multiparous women (P = 0.0392), and was not associated with any tumor-related features in the affected breast. Masood Score was higher with shorter interval since last pregnancy (R = 0.204, P = 0.0417), higher number of births (R = 0.369, P = 0.0006), and estrogen receptor (ER) negativity of the index cancer (R = −0.203, P = 0.065). Individual cytologic features were associated with aspects of parity. Specifically, anisonucleosis was correlated with shorter interval since last pregnancy (R = 0.318, P = 0.0201), higher number of births (R = 0.382, P = 0.0004), and ER status (R = −0.314, P = 0.0038). Eight estrogen-regulated genes were increased in atypical samples (P < 0.005), including TFF1, AGT, PDZK1, PGR, GREB1, PRLR, CAMK2B, and CCND1. Conclusions Cytologic atypia, and particularly anisonucleosis, is associated with recent and multiple births and ER negative status of the index tumor. Atypical samples showed increased expression of estrogen-related genes, consistent with the role of estrogen exposure in breast cancer development.</description><subject>Adult</subject><subject>Aged</subject><subject>Anisonucleosis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biopsy, Fine-Needle</subject><subject>Breast - cytology</subject><subject>Breast - metabolism</subject><subject>Breast cancer</subject><subject>Breast cancer risk</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - surgery</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - surgery</subject><subject>Carcinoma, Lobular - diagnosis</subject><subject>Carcinoma, Lobular - genetics</subject><subject>Carcinoma, Lobular - surgery</subject><subject>Case-Control Studies</subject><subject>Contralateral unaffected breast</subject><subject>Cytologic atypia</subject><subject>Estrogens</subject><subject>Estrogens - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genomics</subject><subject>Health risk assessment</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Histology</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Kinases</subject><subject>Mastectomy</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Random fine needle aspiration</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Progesterone - genetics</subject><subject>Signal Transduction</subject><subject>Surgery</subject><issn>0960-7404</issn><issn>1879-3320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LHCEQhiVkyU42-QchCLnk0r1q29peAmHIFyzsIXsXxy4nTnp0ovZC__u1md0E9hIQFep5y7LeQugdJS0lVFwf2jynGGzLCO1bylpC6Au0oYNUTdcx8hJtiBKkkZzwS_Q65wMhREhGX6FLJoZeSEk3aL9dSpzi3ltsynLyBvuAyy_ANoaSzGQK1B3PwTgHtsCIdwlMLthnnGANj7hEfDLJlwWbMGLIJcU9hOYpXO-Q36ALZ6YMbx_PK3T39cvd9ntzc_vtx_bzTWM570vTS9tzviO2t9YZZZkxwJWQyu2kU64bHVOKctdxK4ToHTc9l46Nw-gU56K7Qh_PaU8p_plrKfros4VpMgHinDUdWJWpuir64Rl6iHMKtbhKcck7QZWsFD9TNsWcEzh9Sv5o0qIp0asP-qDPPujVB02Zrj5U2fvH5PPuCONf0VPjK_DpDEBtxr2HpLP1ECyMPtU-6zH6_73wPIGdfPDWTL9hgfzvLzpXgf65zsI6CrTvCOkG3j0ASBGxEg</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Monahan, Denise A</creator><creator>Wang, Jun</creator><creator>Lee, Oukseub</creator><creator>Revesz, Elizabeth</creator><creator>Taft, Nancy</creator><creator>Ivancic, David</creator><creator>Hansen, Nora M</creator><creator>Bethke, Kevin P</creator><creator>Zalles, C</creator><creator>Khan, Seema A</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes</title><author>Monahan, Denise A ; Wang, Jun ; Lee, Oukseub ; Revesz, Elizabeth ; Taft, Nancy ; Ivancic, David ; Hansen, Nora M ; Bethke, Kevin P ; Zalles, C ; Khan, Seema A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-57c544b0c5ccfa9c2aae49679fb7f9f3df29914f34c6665f4a547f2d8df94463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anisonucleosis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biopsy, Fine-Needle</topic><topic>Breast - cytology</topic><topic>Breast - metabolism</topic><topic>Breast cancer</topic><topic>Breast cancer risk</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - surgery</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - surgery</topic><topic>Carcinoma, Lobular - diagnosis</topic><topic>Carcinoma, Lobular - genetics</topic><topic>Carcinoma, Lobular - surgery</topic><topic>Case-Control Studies</topic><topic>Contralateral unaffected breast</topic><topic>Cytologic atypia</topic><topic>Estrogens</topic><topic>Estrogens - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Genomics</topic><topic>Health risk assessment</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Histology</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Kinases</topic><topic>Mastectomy</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Random fine needle aspiration</topic><topic>Receptors, Estrogen - genetics</topic><topic>Receptors, Progesterone - genetics</topic><topic>Signal Transduction</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monahan, Denise A</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Lee, Oukseub</creatorcontrib><creatorcontrib>Revesz, Elizabeth</creatorcontrib><creatorcontrib>Taft, Nancy</creatorcontrib><creatorcontrib>Ivancic, David</creatorcontrib><creatorcontrib>Hansen, Nora M</creatorcontrib><creatorcontrib>Bethke, Kevin P</creatorcontrib><creatorcontrib>Zalles, C</creatorcontrib><creatorcontrib>Khan, Seema A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monahan, Denise A</au><au>Wang, Jun</au><au>Lee, Oukseub</au><au>Revesz, Elizabeth</au><au>Taft, Nancy</au><au>Ivancic, David</au><au>Hansen, Nora M</au><au>Bethke, Kevin P</au><au>Zalles, C</au><au>Khan, Seema A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes</atitle><jtitle>Surgical oncology</jtitle><addtitle>Surg Oncol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>25</volume><issue>4</issue><spage>449</spage><epage>456</epage><pages>449-456</pages><issn>0960-7404</issn><eissn>1879-3320</eissn><abstract>Abstract Purpose The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs of newly diagnosed breast cancer patients. Methods 83 women underwent rFNA of the CUB. Cytologic analysis was performed using the Masood Score (MS), atypia was defined as MS > 14. RNA was extracted using 80% of the sample. The expression of 20 hormone related genes was quantified using Taqman Low Density Arrays. Statistical analysis was performed using 2-tailed t tests and linear regression. Results Cytological atypia was more frequent in multiparous women (P = 0.0392), and was not associated with any tumor-related features in the affected breast. Masood Score was higher with shorter interval since last pregnancy (R = 0.204, P = 0.0417), higher number of births (R = 0.369, P = 0.0006), and estrogen receptor (ER) negativity of the index cancer (R = −0.203, P = 0.065). Individual cytologic features were associated with aspects of parity. Specifically, anisonucleosis was correlated with shorter interval since last pregnancy (R = 0.318, P = 0.0201), higher number of births (R = 0.382, P = 0.0004), and ER status (R = −0.314, P = 0.0038). Eight estrogen-regulated genes were increased in atypical samples (P < 0.005), including TFF1, AGT, PDZK1, PGR, GREB1, PRLR, CAMK2B, and CCND1. Conclusions Cytologic atypia, and particularly anisonucleosis, is associated with recent and multiple births and ER negative status of the index tumor. Atypical samples showed increased expression of estrogen-related genes, consistent with the role of estrogen exposure in breast cancer development.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26856771</pmid><doi>10.1016/j.suronc.2015.12.001</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Anisonucleosis Biomarkers, Tumor - genetics Biopsy, Fine-Needle Breast - cytology Breast - metabolism Breast cancer Breast cancer risk Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - surgery Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - surgery Carcinoma, Lobular - diagnosis Carcinoma, Lobular - genetics Carcinoma, Lobular - surgery Case-Control Studies Contralateral unaffected breast Cytologic atypia Estrogens Estrogens - metabolism Female Follow-Up Studies Gene expression Gene Expression Profiling Genomics Health risk assessment Hematology, Oncology and Palliative Medicine Histology Humans Hypotheses Kinases Mastectomy Middle Aged Neoplasm Grading Parity Pregnancy Prognosis Proteins Random fine needle aspiration Receptors, Estrogen - genetics Receptors, Progesterone - genetics Signal Transduction Surgery |
| title | Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes |
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