Effects of hemarthrosis on cartilage and synovium in rabbits
Purpose To provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage. Methods Twenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hemato...
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| Veröffentlicht in: | European journal of trauma and emergency surgery (Munich : 2007) 2017-04, Vol.43 (2), p.249-253 |
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| container_title | European journal of trauma and emergency surgery (Munich : 2007) |
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| creator | Li, L. Zhao, D. Chen, DF Zhang, ES Guo, SY |
| description | Purpose
To provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage.
Methods
Twenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hematoma group, HA group and control group. These rabbits were killed at 4 days, 2, 4 and 8 weeks, respectively.
Results
Knee articular cartilage and synovium were obtained to detect histology, histochemistry and chondroitin proteoglycans (PG). Morphologies of cartilage and synovium in the control group were normal, while cartilage cells were detected hyperplasia of activation and each layer was disorganized in hematoma groups with 4 days and 2 weeks. Compared to the control group, concentrations of PG in 4 days and 2 weeks groups were significantly reduced (
p
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| doi_str_mv | 10.1007/s00068-016-0648-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826655298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321403437</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-154ef325aeec796773882ccf28d0013f1467be54e4f46d30ba6c507be05f823b3</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotlYfwI0MuHEzenKZJANupNQLFNzoOmQySTtlLjWZEfr2pkwVEVwlJ_nOn5wPoUsMtxhA3AUA4DIFzFPgTKbiCE2x5DTNc4aPf_aUTtBZCJsIA8_IKZoQnlOOcz5F9wvnrOlD0rlkbRvt-7XvQhXrNjGxqmq9soluyyTs2u6zGpqkahOvi6Lqwzk6cboO9uKwztD74-Jt_pwuX59e5g_L1FBB-hRnzDpKMm2tETkXgkpJjHFElgCYOsy4KGyEmGO8pFBobjKIR5A5SWhBZ-hmzN367mOwoVdNFYyta93abggKS8J5lpFcRvT6D7rpBt_G30VKUiYA5yxSeKRMHDZ469TWV3H4ncKg9mrVqFZFtWqvVonYc3VIHorGlj8d3y4jQEYgxKt2Zf2vp_9N_QIxXII-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1883470194</pqid></control><display><type>article</type><title>Effects of hemarthrosis on cartilage and synovium in rabbits</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Li, L. ; Zhao, D. ; Chen, DF ; Zhang, ES ; Guo, SY</creator><creatorcontrib>Li, L. ; Zhao, D. ; Chen, DF ; Zhang, ES ; Guo, SY</creatorcontrib><description>Purpose
To provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage.
Methods
Twenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hematoma group, HA group and control group. These rabbits were killed at 4 days, 2, 4 and 8 weeks, respectively.
Results
Knee articular cartilage and synovium were obtained to detect histology, histochemistry and chondroitin proteoglycans (PG). Morphologies of cartilage and synovium in the control group were normal, while cartilage cells were detected hyperplasia of activation and each layer was disorganized in hematoma groups with 4 days and 2 weeks. Compared to the control group, concentrations of PG in 4 days and 2 weeks groups were significantly reduced (
p
< 0.05), while no significant difference was detected between 4 weeks group and the control group. Morphology was recovered normal in 8 weeks. Compared to hematoma group, morphology and histochemistry were improved in HA group at each time frame.
Conclusions
Simple acute hematoma can lead to temporary change of morphology and biochemistry. Application of HA can reduce damage of hemarthrosis on cartilaginous and shorten the cartilage recovery time.</description><identifier>ISSN: 1863-9933</identifier><identifier>EISSN: 1863-9941</identifier><identifier>DOI: 10.1007/s00068-016-0648-7</identifier><identifier>PMID: 26936196</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; Blood ; Cartilage ; Cartilage, Articular - pathology ; Critical Care Medicine ; Disease Models, Animal ; Emergency Medicine ; Hemarthrosis - pathology ; Histology ; Hyaluronic Acid - pharmacology ; Intensive ; Knee Joint - pathology ; Laboratory animals ; Male ; Medical treatment ; Medicine ; Medicine & Public Health ; Original Article ; Proteoglycans ; Rabbits ; Sports Medicine ; Surgery ; Surgical Orthopedics ; Synovial Membrane - pathology ; Traumatic Surgery</subject><ispartof>European journal of trauma and emergency surgery (Munich : 2007), 2017-04, Vol.43 (2), p.249-253</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>European Journal of Trauma and Emergency Surgery is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-154ef325aeec796773882ccf28d0013f1467be54e4f46d30ba6c507be05f823b3</citedby><cites>FETCH-LOGICAL-c372t-154ef325aeec796773882ccf28d0013f1467be54e4f46d30ba6c507be05f823b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00068-016-0648-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00068-016-0648-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26936196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Zhao, D.</creatorcontrib><creatorcontrib>Chen, DF</creatorcontrib><creatorcontrib>Zhang, ES</creatorcontrib><creatorcontrib>Guo, SY</creatorcontrib><title>Effects of hemarthrosis on cartilage and synovium in rabbits</title><title>European journal of trauma and emergency surgery (Munich : 2007)</title><addtitle>Eur J Trauma Emerg Surg</addtitle><addtitle>Eur J Trauma Emerg Surg</addtitle><description>Purpose
To provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage.
Methods
Twenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hematoma group, HA group and control group. These rabbits were killed at 4 days, 2, 4 and 8 weeks, respectively.
Results
Knee articular cartilage and synovium were obtained to detect histology, histochemistry and chondroitin proteoglycans (PG). Morphologies of cartilage and synovium in the control group were normal, while cartilage cells were detected hyperplasia of activation and each layer was disorganized in hematoma groups with 4 days and 2 weeks. Compared to the control group, concentrations of PG in 4 days and 2 weeks groups were significantly reduced (
p
< 0.05), while no significant difference was detected between 4 weeks group and the control group. Morphology was recovered normal in 8 weeks. Compared to hematoma group, morphology and histochemistry were improved in HA group at each time frame.
Conclusions
Simple acute hematoma can lead to temporary change of morphology and biochemistry. Application of HA can reduce damage of hemarthrosis on cartilaginous and shorten the cartilage recovery time.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Blood</subject><subject>Cartilage</subject><subject>Cartilage, Articular - pathology</subject><subject>Critical Care Medicine</subject><subject>Disease Models, Animal</subject><subject>Emergency Medicine</subject><subject>Hemarthrosis - pathology</subject><subject>Histology</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Intensive</subject><subject>Knee Joint - pathology</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Proteoglycans</subject><subject>Rabbits</subject><subject>Sports Medicine</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Synovial Membrane - pathology</subject><subject>Traumatic Surgery</subject><issn>1863-9933</issn><issn>1863-9941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0MuHEzenKZJANupNQLFNzoOmQySTtlLjWZEfr2pkwVEVwlJ_nOn5wPoUsMtxhA3AUA4DIFzFPgTKbiCE2x5DTNc4aPf_aUTtBZCJsIA8_IKZoQnlOOcz5F9wvnrOlD0rlkbRvt-7XvQhXrNjGxqmq9soluyyTs2u6zGpqkahOvi6Lqwzk6cboO9uKwztD74-Jt_pwuX59e5g_L1FBB-hRnzDpKMm2tETkXgkpJjHFElgCYOsy4KGyEmGO8pFBobjKIR5A5SWhBZ-hmzN367mOwoVdNFYyta93abggKS8J5lpFcRvT6D7rpBt_G30VKUiYA5yxSeKRMHDZ469TWV3H4ncKg9mrVqFZFtWqvVonYc3VIHorGlj8d3y4jQEYgxKt2Zf2vp_9N_QIxXII-</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Li, L.</creator><creator>Zhao, D.</creator><creator>Chen, DF</creator><creator>Zhang, ES</creator><creator>Guo, SY</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Effects of hemarthrosis on cartilage and synovium in rabbits</title><author>Li, L. ; Zhao, D. ; Chen, DF ; Zhang, ES ; Guo, SY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-154ef325aeec796773882ccf28d0013f1467be54e4f46d30ba6c507be05f823b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Blood</topic><topic>Cartilage</topic><topic>Cartilage, Articular - pathology</topic><topic>Critical Care Medicine</topic><topic>Disease Models, Animal</topic><topic>Emergency Medicine</topic><topic>Hemarthrosis - pathology</topic><topic>Histology</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Intensive</topic><topic>Knee Joint - pathology</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Proteoglycans</topic><topic>Rabbits</topic><topic>Sports Medicine</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Synovial Membrane - pathology</topic><topic>Traumatic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Zhao, D.</creatorcontrib><creatorcontrib>Chen, DF</creatorcontrib><creatorcontrib>Zhang, ES</creatorcontrib><creatorcontrib>Guo, SY</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of trauma and emergency surgery (Munich : 2007)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, L.</au><au>Zhao, D.</au><au>Chen, DF</au><au>Zhang, ES</au><au>Guo, SY</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of hemarthrosis on cartilage and synovium in rabbits</atitle><jtitle>European journal of trauma and emergency surgery (Munich : 2007)</jtitle><stitle>Eur J Trauma Emerg Surg</stitle><addtitle>Eur J Trauma Emerg Surg</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>43</volume><issue>2</issue><spage>249</spage><epage>253</epage><pages>249-253</pages><issn>1863-9933</issn><eissn>1863-9941</eissn><abstract>Purpose
To provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage.
Methods
Twenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hematoma group, HA group and control group. These rabbits were killed at 4 days, 2, 4 and 8 weeks, respectively.
Results
Knee articular cartilage and synovium were obtained to detect histology, histochemistry and chondroitin proteoglycans (PG). Morphologies of cartilage and synovium in the control group were normal, while cartilage cells were detected hyperplasia of activation and each layer was disorganized in hematoma groups with 4 days and 2 weeks. Compared to the control group, concentrations of PG in 4 days and 2 weeks groups were significantly reduced (
p
< 0.05), while no significant difference was detected between 4 weeks group and the control group. Morphology was recovered normal in 8 weeks. Compared to hematoma group, morphology and histochemistry were improved in HA group at each time frame.
Conclusions
Simple acute hematoma can lead to temporary change of morphology and biochemistry. Application of HA can reduce damage of hemarthrosis on cartilaginous and shorten the cartilage recovery time.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26936196</pmid><doi>10.1007/s00068-016-0648-7</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adjuvants, Immunologic - pharmacology Animals Blood Cartilage Cartilage, Articular - pathology Critical Care Medicine Disease Models, Animal Emergency Medicine Hemarthrosis - pathology Histology Hyaluronic Acid - pharmacology Intensive Knee Joint - pathology Laboratory animals Male Medical treatment Medicine Medicine & Public Health Original Article Proteoglycans Rabbits Sports Medicine Surgery Surgical Orthopedics Synovial Membrane - pathology Traumatic Surgery |
| title | Effects of hemarthrosis on cartilage and synovium in rabbits |
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