KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model
The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to...
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| Veröffentlicht in: | Journal of tissue engineering and regenerative medicine 2017-07, Vol.11 (7), p.2024-2033 |
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| creator | Weng, Shao‐Ju Li, I‐Hsun Huang, Yuahn‐Sieh Chueh, Sheau‐Huei Chou, Ta‐Kai Huang, San‐Yuan Shiue, Chyng‐Yann Cheng, Cheng‐Yi Ma, Kuo‐Hsing |
| description | The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to generate an artificial tract and reconstruct the nigrostriatal pathway in 6‐hydroxydopamine (6‐OHDA) lesioned rats. In this study, we used KA bridging and a co‐graft of rat olfactory ensheathing cells (OECs) and rat E14 embryonic ventral mesencephalic (VM) tissue to restore the nigrostriatal pathway of the PD model rats. The methamphetamine‐induced rotational behaviour, 4‐[18F]–ADAM (a selectively serotonin transporter radioligand)/micro‐PET imaging, and immunohistochemistry were used to assess the effects of the transplantation. At 9 weeks post‐grafting in PD model rats, the results showed that the PD rats undergoing VM tissue and OECs co‐grafts (VM–OECs) exhibited better motor recovery compared to the rats receiving VM tissue transplantation only. The striatal uptake of 4‐[18F]–ADAM and tyrosine hydroxylase immunoreactivity (TH‐ir) of the grafted area in the VM–OECs group were also more improved than those of the VM alone group. These results suggested that OECs may enhance the survival of the grafted VM tissue and facilitate the recovery of motor function after VM transplantation. Moreover, OECs possibly promote the elongation of dopaminergic and serotonergic axon in the bridging graft. Copyright © 2015 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/term.2098 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826648865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826648865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3548-8467d4798977b0ee2bf0d264af2acbddacc419f6ebe3404a37fcb21c7638ac133</originalsourceid><addsrcrecordid>eNpdkc1u1TAQhS0EouXCghdAltiwua3_kjjLqmoB0QqEytqa2JNel8QOtiN0dzxCn5EnIVEvXXQ1RzOfRkfnEPKWsxPOmDgtmMYTwVr9jBzzVoptw1j1_KBrUakj8irnu2VZ1ZV8SY5EXfEF18dk-nL29899l7y7RUdLgpCnAUKB4mOgsacjZgwWpx0M3tLic56RQnA0Dj3YEtOeYsg7hLLz4ZZaHIZMfaBAv0H66UOOwUOgCQodo8PhNXnRw5DxzWFuyI_Li5vzT9urrx8_n59dba2slN5qVTdONa1um6ZjiKLrmRO1gl6A7ZwDaxVv-xo7lIopkE1vO8FtU0sNlku5IR8e_k4p_poxFzP6vLqDgHHOhmtR10rrJZANef8EvYtzCos7w1teSSYa3SzUuwM1dyM6MyU_Qtqb_1kuwOkD8NsPuH-8c2bWksxakllLMjcX369XIf8BN5SG0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1915302787</pqid></control><display><type>article</type><title>KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Weng, Shao‐Ju ; Li, I‐Hsun ; Huang, Yuahn‐Sieh ; Chueh, Sheau‐Huei ; Chou, Ta‐Kai ; Huang, San‐Yuan ; Shiue, Chyng‐Yann ; Cheng, Cheng‐Yi ; Ma, Kuo‐Hsing</creator><creatorcontrib>Weng, Shao‐Ju ; Li, I‐Hsun ; Huang, Yuahn‐Sieh ; Chueh, Sheau‐Huei ; Chou, Ta‐Kai ; Huang, San‐Yuan ; Shiue, Chyng‐Yann ; Cheng, Cheng‐Yi ; Ma, Kuo‐Hsing</creatorcontrib><description>The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to generate an artificial tract and reconstruct the nigrostriatal pathway in 6‐hydroxydopamine (6‐OHDA) lesioned rats. In this study, we used KA bridging and a co‐graft of rat olfactory ensheathing cells (OECs) and rat E14 embryonic ventral mesencephalic (VM) tissue to restore the nigrostriatal pathway of the PD model rats. The methamphetamine‐induced rotational behaviour, 4‐[18F]–ADAM (a selectively serotonin transporter radioligand)/micro‐PET imaging, and immunohistochemistry were used to assess the effects of the transplantation. At 9 weeks post‐grafting in PD model rats, the results showed that the PD rats undergoing VM tissue and OECs co‐grafts (VM–OECs) exhibited better motor recovery compared to the rats receiving VM tissue transplantation only. The striatal uptake of 4‐[18F]–ADAM and tyrosine hydroxylase immunoreactivity (TH‐ir) of the grafted area in the VM–OECs group were also more improved than those of the VM alone group. These results suggested that OECs may enhance the survival of the grafted VM tissue and facilitate the recovery of motor function after VM transplantation. Moreover, OECs possibly promote the elongation of dopaminergic and serotonergic axon in the bridging graft. Copyright © 2015 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1932-6254</identifier><identifier>EISSN: 1932-7005</identifier><identifier>DOI: 10.1002/term.2098</identifier><identifier>PMID: 26510988</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>4‐[18F]–ADAM ; 6-Hydroxydopamine ; Amino acids ; Animals ; Basal ganglia ; Bridging ; bridging transplantation ; Central nervous system diseases ; Circuits ; Damage ; Dopamine receptors ; Elongation ; Embryos ; Grafting ; Grafts ; Hydroxylase ; Immunohistochemistry ; Kainic acid ; Male ; mesencephalic tissue ; Mesencephalon - transplantation ; Methamphetamine ; Motor task performance ; Movement disorders ; Neostriatum ; Neurodegenerative diseases ; Olfactory Bulb - transplantation ; olfactory ensheathing cell ; Olfactory ensheathing cells ; Oxidopamine - adverse effects ; Oxidopamine - pharmacology ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - pathology ; Parkinson Disease, Secondary - physiopathology ; Parkinson Disease, Secondary - surgery ; Parkinson's disease ; Positron emission ; rat model ; Rats ; Rats, Sprague-Dawley ; Recovery ; Regenerative medicine ; Rodents ; Rotational behavior ; Serotonin ; Survival ; Tissue engineering ; Tomography ; Transplantation ; Tyrosine</subject><ispartof>Journal of tissue engineering and regenerative medicine, 2017-07, Vol.11 (7), p.2024-2033</ispartof><rights>Copyright © 2015 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3548-8467d4798977b0ee2bf0d264af2acbddacc419f6ebe3404a37fcb21c7638ac133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fterm.2098$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fterm.2098$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26510988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weng, Shao‐Ju</creatorcontrib><creatorcontrib>Li, I‐Hsun</creatorcontrib><creatorcontrib>Huang, Yuahn‐Sieh</creatorcontrib><creatorcontrib>Chueh, Sheau‐Huei</creatorcontrib><creatorcontrib>Chou, Ta‐Kai</creatorcontrib><creatorcontrib>Huang, San‐Yuan</creatorcontrib><creatorcontrib>Shiue, Chyng‐Yann</creatorcontrib><creatorcontrib>Cheng, Cheng‐Yi</creatorcontrib><creatorcontrib>Ma, Kuo‐Hsing</creatorcontrib><title>KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model</title><title>Journal of tissue engineering and regenerative medicine</title><addtitle>J Tissue Eng Regen Med</addtitle><description>The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to generate an artificial tract and reconstruct the nigrostriatal pathway in 6‐hydroxydopamine (6‐OHDA) lesioned rats. In this study, we used KA bridging and a co‐graft of rat olfactory ensheathing cells (OECs) and rat E14 embryonic ventral mesencephalic (VM) tissue to restore the nigrostriatal pathway of the PD model rats. The methamphetamine‐induced rotational behaviour, 4‐[18F]–ADAM (a selectively serotonin transporter radioligand)/micro‐PET imaging, and immunohistochemistry were used to assess the effects of the transplantation. At 9 weeks post‐grafting in PD model rats, the results showed that the PD rats undergoing VM tissue and OECs co‐grafts (VM–OECs) exhibited better motor recovery compared to the rats receiving VM tissue transplantation only. The striatal uptake of 4‐[18F]–ADAM and tyrosine hydroxylase immunoreactivity (TH‐ir) of the grafted area in the VM–OECs group were also more improved than those of the VM alone group. These results suggested that OECs may enhance the survival of the grafted VM tissue and facilitate the recovery of motor function after VM transplantation. Moreover, OECs possibly promote the elongation of dopaminergic and serotonergic axon in the bridging graft. Copyright © 2015 John Wiley & Sons, Ltd.</description><subject>4‐[18F]–ADAM</subject><subject>6-Hydroxydopamine</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Basal ganglia</subject><subject>Bridging</subject><subject>bridging transplantation</subject><subject>Central nervous system diseases</subject><subject>Circuits</subject><subject>Damage</subject><subject>Dopamine receptors</subject><subject>Elongation</subject><subject>Embryos</subject><subject>Grafting</subject><subject>Grafts</subject><subject>Hydroxylase</subject><subject>Immunohistochemistry</subject><subject>Kainic acid</subject><subject>Male</subject><subject>mesencephalic tissue</subject><subject>Mesencephalon - transplantation</subject><subject>Methamphetamine</subject><subject>Motor task performance</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neurodegenerative diseases</subject><subject>Olfactory Bulb - transplantation</subject><subject>olfactory ensheathing cell</subject><subject>Olfactory ensheathing cells</subject><subject>Oxidopamine - adverse effects</subject><subject>Oxidopamine - pharmacology</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - pathology</subject><subject>Parkinson Disease, Secondary - physiopathology</subject><subject>Parkinson Disease, Secondary - surgery</subject><subject>Parkinson's disease</subject><subject>Positron emission</subject><subject>rat model</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery</subject><subject>Regenerative medicine</subject><subject>Rodents</subject><subject>Rotational behavior</subject><subject>Serotonin</subject><subject>Survival</subject><subject>Tissue engineering</subject><subject>Tomography</subject><subject>Transplantation</subject><subject>Tyrosine</subject><issn>1932-6254</issn><issn>1932-7005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1TAQhS0EouXCghdAltiwua3_kjjLqmoB0QqEytqa2JNel8QOtiN0dzxCn5EnIVEvXXQ1RzOfRkfnEPKWsxPOmDgtmMYTwVr9jBzzVoptw1j1_KBrUakj8irnu2VZ1ZV8SY5EXfEF18dk-nL29899l7y7RUdLgpCnAUKB4mOgsacjZgwWpx0M3tLic56RQnA0Dj3YEtOeYsg7hLLz4ZZaHIZMfaBAv0H66UOOwUOgCQodo8PhNXnRw5DxzWFuyI_Li5vzT9urrx8_n59dba2slN5qVTdONa1um6ZjiKLrmRO1gl6A7ZwDaxVv-xo7lIopkE1vO8FtU0sNlku5IR8e_k4p_poxFzP6vLqDgHHOhmtR10rrJZANef8EvYtzCos7w1teSSYa3SzUuwM1dyM6MyU_Qtqb_1kuwOkD8NsPuH-8c2bWksxakllLMjcX369XIf8BN5SG0w</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Weng, Shao‐Ju</creator><creator>Li, I‐Hsun</creator><creator>Huang, Yuahn‐Sieh</creator><creator>Chueh, Sheau‐Huei</creator><creator>Chou, Ta‐Kai</creator><creator>Huang, San‐Yuan</creator><creator>Shiue, Chyng‐Yann</creator><creator>Cheng, Cheng‐Yi</creator><creator>Ma, Kuo‐Hsing</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model</title><author>Weng, Shao‐Ju ; Li, I‐Hsun ; Huang, Yuahn‐Sieh ; Chueh, Sheau‐Huei ; Chou, Ta‐Kai ; Huang, San‐Yuan ; Shiue, Chyng‐Yann ; Cheng, Cheng‐Yi ; Ma, Kuo‐Hsing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3548-8467d4798977b0ee2bf0d264af2acbddacc419f6ebe3404a37fcb21c7638ac133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>4‐[18F]–ADAM</topic><topic>6-Hydroxydopamine</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Basal ganglia</topic><topic>Bridging</topic><topic>bridging transplantation</topic><topic>Central nervous system diseases</topic><topic>Circuits</topic><topic>Damage</topic><topic>Dopamine receptors</topic><topic>Elongation</topic><topic>Embryos</topic><topic>Grafting</topic><topic>Grafts</topic><topic>Hydroxylase</topic><topic>Immunohistochemistry</topic><topic>Kainic acid</topic><topic>Male</topic><topic>mesencephalic tissue</topic><topic>Mesencephalon - transplantation</topic><topic>Methamphetamine</topic><topic>Motor task performance</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neurodegenerative diseases</topic><topic>Olfactory Bulb - transplantation</topic><topic>olfactory ensheathing cell</topic><topic>Olfactory ensheathing cells</topic><topic>Oxidopamine - adverse effects</topic><topic>Oxidopamine - pharmacology</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - pathology</topic><topic>Parkinson Disease, Secondary - physiopathology</topic><topic>Parkinson Disease, Secondary - surgery</topic><topic>Parkinson's disease</topic><topic>Positron emission</topic><topic>rat model</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery</topic><topic>Regenerative medicine</topic><topic>Rodents</topic><topic>Rotational behavior</topic><topic>Serotonin</topic><topic>Survival</topic><topic>Tissue engineering</topic><topic>Tomography</topic><topic>Transplantation</topic><topic>Tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weng, Shao‐Ju</creatorcontrib><creatorcontrib>Li, I‐Hsun</creatorcontrib><creatorcontrib>Huang, Yuahn‐Sieh</creatorcontrib><creatorcontrib>Chueh, Sheau‐Huei</creatorcontrib><creatorcontrib>Chou, Ta‐Kai</creatorcontrib><creatorcontrib>Huang, San‐Yuan</creatorcontrib><creatorcontrib>Shiue, Chyng‐Yann</creatorcontrib><creatorcontrib>Cheng, Cheng‐Yi</creatorcontrib><creatorcontrib>Ma, Kuo‐Hsing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tissue engineering and regenerative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weng, Shao‐Ju</au><au>Li, I‐Hsun</au><au>Huang, Yuahn‐Sieh</au><au>Chueh, Sheau‐Huei</au><au>Chou, Ta‐Kai</au><au>Huang, San‐Yuan</au><au>Shiue, Chyng‐Yann</au><au>Cheng, Cheng‐Yi</au><au>Ma, Kuo‐Hsing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model</atitle><jtitle>Journal of tissue engineering and regenerative medicine</jtitle><addtitle>J Tissue Eng Regen Med</addtitle><date>2017-07</date><risdate>2017</risdate><volume>11</volume><issue>7</issue><spage>2024</spage><epage>2033</epage><pages>2024-2033</pages><issn>1932-6254</issn><eissn>1932-7005</eissn><abstract>The pathology of Parkinson's disease (PD) results mainly from nigrostriatal pathway damage. Unfortunately, commonly used PD therapies do not repair the disconnected circuitry. It has been reported that using kainic acid (KA, an excitatory amino acid) in bridging transplantation may be useful to generate an artificial tract and reconstruct the nigrostriatal pathway in 6‐hydroxydopamine (6‐OHDA) lesioned rats. In this study, we used KA bridging and a co‐graft of rat olfactory ensheathing cells (OECs) and rat E14 embryonic ventral mesencephalic (VM) tissue to restore the nigrostriatal pathway of the PD model rats. The methamphetamine‐induced rotational behaviour, 4‐[18F]–ADAM (a selectively serotonin transporter radioligand)/micro‐PET imaging, and immunohistochemistry were used to assess the effects of the transplantation. At 9 weeks post‐grafting in PD model rats, the results showed that the PD rats undergoing VM tissue and OECs co‐grafts (VM–OECs) exhibited better motor recovery compared to the rats receiving VM tissue transplantation only. The striatal uptake of 4‐[18F]–ADAM and tyrosine hydroxylase immunoreactivity (TH‐ir) of the grafted area in the VM–OECs group were also more improved than those of the VM alone group. These results suggested that OECs may enhance the survival of the grafted VM tissue and facilitate the recovery of motor function after VM transplantation. Moreover, OECs possibly promote the elongation of dopaminergic and serotonergic axon in the bridging graft. Copyright © 2015 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>26510988</pmid><doi>10.1002/term.2098</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 4‐[18F]–ADAM 6-Hydroxydopamine Amino acids Animals Basal ganglia Bridging bridging transplantation Central nervous system diseases Circuits Damage Dopamine receptors Elongation Embryos Grafting Grafts Hydroxylase Immunohistochemistry Kainic acid Male mesencephalic tissue Mesencephalon - transplantation Methamphetamine Motor task performance Movement disorders Neostriatum Neurodegenerative diseases Olfactory Bulb - transplantation olfactory ensheathing cell Olfactory ensheathing cells Oxidopamine - adverse effects Oxidopamine - pharmacology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - pathology Parkinson Disease, Secondary - physiopathology Parkinson Disease, Secondary - surgery Parkinson's disease Positron emission rat model Rats Rats, Sprague-Dawley Recovery Regenerative medicine Rodents Rotational behavior Serotonin Survival Tissue engineering Tomography Transplantation Tyrosine |
| title | KA‐bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model |
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