Extension of in vivo half-life of biologically active molecules by XTEN protein polymers

XTEN™ is a class of unstructured hydrophilic, biodegradable protein polymers designed to increase the half-lives of therapeutic peptides and proteins. XTEN polymers and XTEN fusion proteins are typically expressed in Escherichia coli and purified by conventional protein chromatography as monodispers...

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Veröffentlicht in:	Journal of controlled release 2016-10, Vol.240, p.52-66
Hauptverfasser:	Podust, Vladimir N., Balan, Sibu, Sim, Bee-Cheng, Coyle, Michael P., Ernst, Ulrich, Peters, Robert T., Schellenberger, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Products - chemistry Biological Products - pharmacokinetics Biotherapeutics Chemical conjugation Clinical Trials as Topic - methods Drug Discovery - methods Drug Discovery - trends Genetic fusion Half-Life Half-life extension Humans Peptides Polymers - chemistry Polymers - pharmacokinetics Protein Structure, Secondary Proteins - chemistry Proteins - pharmacokinetics XTEN protein polymer
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