Metabolic parameters and cognitive function in a cohort of older diabetic patients
Background Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understoo...
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| Veröffentlicht in: | Aging clinical and experimental research 2016-12, Vol.28 (6), p.1105-1112 |
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| container_title | Aging clinical and experimental research |
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| creator | Herghelegiu, Anna Marie Nacu, Raluca Mihaela Prada, Gabriel Ioan |
| description | Background
Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understood.
Aims
The main objective of this study was to investigate the relationship between metabolic parameters and the cognitive function in older diabetics.
Methods
A total number of 360 diabetic subjects, age 65 years and over, and 300 older people controls were included. Clinical and biological parameters, together with the cognitive function, were assessed every 6 months over a 18-month period, for each study participant.
Results
By employing a multivariate linear regression analysis, several significant relationships have been identified: between Clock Drawing Test (CDT) scores and HbA1c (
R
2
= 0.68); between CDT scores (
R
2
= 0.51) and overall MMSE scores (
R
2
= 0.43) on one hand, and DM duration in years, on the other hand; also between CDT scores and BMI (
R
2
= 0.59). There was no significant association between fasting serum glucose (FSG), total serum cholesterol, LDL cholesterol or triglycerides levels and cognitive function scores (
p
> 0.05).
Conclusions
The close detailed monitoring of the cognitive function and a rigorous metabolic control are important, especially in the very early stages of DM. Addressing factors such as weight control in older diabetic patients could contribute to better cognitive outcomes. |
| doi_str_mv | 10.1007/s40520-015-0515-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826648045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2349117077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-bba6ebd5cd5440d099b11cf38d7df20cdbc752bf4b75b70219446181fe02d0243</originalsourceid><addsrcrecordid>eNp1kEtr3TAQhUVoyfsHZFME3WTjdkaWLXtZQl6QEAjpWujlVMFXupXkQv59dHvTNBS60WhmvnMkDiEnCF8QQHzNHDoGDWDXQLc5dsg-ijoZWhw_vLvvkYOcnwA41maX7LFeMDFiu0_ub11ROs7e0LVKauWKS5mqYKmJj8EX_8vRaQmm-BioD1TV-Y-YCo0TjbN1iVqvtCu_9cW7UPIR-TipObvj13pIvl-cP5xdNTd3l9dn324a0wpWGq1V77TtjO04BwvjqBHN1A5W2ImBsdqIjumJa9FpAQxHznsccHLALDDeHpLTre86xZ-Ly0WufDZunlVwcckSB9b3fADeVfTzP-hTXFKov5Os5SOiACEqhVvKpJhzcpNcJ79S6VkiyE3gchu4rIHLTeASqubTq_OiV86-Kf4kXAG2BXJdhUeX_j79f9cXUHGKiw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2349117077</pqid></control><display><type>article</type><title>Metabolic parameters and cognitive function in a cohort of older diabetic patients</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Herghelegiu, Anna Marie ; Nacu, Raluca Mihaela ; Prada, Gabriel Ioan</creator><creatorcontrib>Herghelegiu, Anna Marie ; Nacu, Raluca Mihaela ; Prada, Gabriel Ioan</creatorcontrib><description>Background
Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understood.
Aims
The main objective of this study was to investigate the relationship between metabolic parameters and the cognitive function in older diabetics.
Methods
A total number of 360 diabetic subjects, age 65 years and over, and 300 older people controls were included. Clinical and biological parameters, together with the cognitive function, were assessed every 6 months over a 18-month period, for each study participant.
Results
By employing a multivariate linear regression analysis, several significant relationships have been identified: between Clock Drawing Test (CDT) scores and HbA1c (
R
2
= 0.68); between CDT scores (
R
2
= 0.51) and overall MMSE scores (
R
2
= 0.43) on one hand, and DM duration in years, on the other hand; also between CDT scores and BMI (
R
2
= 0.59). There was no significant association between fasting serum glucose (FSG), total serum cholesterol, LDL cholesterol or triglycerides levels and cognitive function scores (
p
> 0.05).
Conclusions
The close detailed monitoring of the cognitive function and a rigorous metabolic control are important, especially in the very early stages of DM. Addressing factors such as weight control in older diabetic patients could contribute to better cognitive outcomes.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-015-0515-0</identifier><identifier>PMID: 26727913</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Aged, 80 and over ; Body Mass Index ; Cholesterol, LDL - analysis ; Cognition - physiology ; Cognitive ability ; Comorbidity ; Dementia ; Dementia - blood ; Dementia - diagnosis ; Dementia - epidemiology ; Dementia - physiopathology ; Diabetes ; Diabetes Mellitus - blood ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - psychology ; Female ; Geriatric Assessment ; Geriatrics/Gerontology ; Glycated Hemoglobin A - analysis ; Humans ; Intelligence Tests ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Original Article ; Prevalence ; Romania - epidemiology ; Statistics as Topic</subject><ispartof>Aging clinical and experimental research, 2016-12, Vol.28 (6), p.1105-1112</ispartof><rights>Springer International Publishing Switzerland 2015</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2015). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-bba6ebd5cd5440d099b11cf38d7df20cdbc752bf4b75b70219446181fe02d0243</citedby><cites>FETCH-LOGICAL-c372t-bba6ebd5cd5440d099b11cf38d7df20cdbc752bf4b75b70219446181fe02d0243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-015-0515-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-015-0515-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26727913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herghelegiu, Anna Marie</creatorcontrib><creatorcontrib>Nacu, Raluca Mihaela</creatorcontrib><creatorcontrib>Prada, Gabriel Ioan</creatorcontrib><title>Metabolic parameters and cognitive function in a cohort of older diabetic patients</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understood.
Aims
The main objective of this study was to investigate the relationship between metabolic parameters and the cognitive function in older diabetics.
Methods
A total number of 360 diabetic subjects, age 65 years and over, and 300 older people controls were included. Clinical and biological parameters, together with the cognitive function, were assessed every 6 months over a 18-month period, for each study participant.
Results
By employing a multivariate linear regression analysis, several significant relationships have been identified: between Clock Drawing Test (CDT) scores and HbA1c (
R
2
= 0.68); between CDT scores (
R
2
= 0.51) and overall MMSE scores (
R
2
= 0.43) on one hand, and DM duration in years, on the other hand; also between CDT scores and BMI (
R
2
= 0.59). There was no significant association between fasting serum glucose (FSG), total serum cholesterol, LDL cholesterol or triglycerides levels and cognitive function scores (
p
> 0.05).
Conclusions
The close detailed monitoring of the cognitive function and a rigorous metabolic control are important, especially in the very early stages of DM. Addressing factors such as weight control in older diabetic patients could contribute to better cognitive outcomes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Mass Index</subject><subject>Cholesterol, LDL - analysis</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Dementia - blood</subject><subject>Dementia - diagnosis</subject><subject>Dementia - epidemiology</subject><subject>Dementia - physiopathology</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - psychology</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Geriatrics/Gerontology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Original Article</subject><subject>Prevalence</subject><subject>Romania - epidemiology</subject><subject>Statistics as Topic</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtr3TAQhUVoyfsHZFME3WTjdkaWLXtZQl6QEAjpWujlVMFXupXkQv59dHvTNBS60WhmvnMkDiEnCF8QQHzNHDoGDWDXQLc5dsg-ijoZWhw_vLvvkYOcnwA41maX7LFeMDFiu0_ub11ROs7e0LVKauWKS5mqYKmJj8EX_8vRaQmm-BioD1TV-Y-YCo0TjbN1iVqvtCu_9cW7UPIR-TipObvj13pIvl-cP5xdNTd3l9dn324a0wpWGq1V77TtjO04BwvjqBHN1A5W2ImBsdqIjumJa9FpAQxHznsccHLALDDeHpLTre86xZ-Ly0WufDZunlVwcckSB9b3fADeVfTzP-hTXFKov5Os5SOiACEqhVvKpJhzcpNcJ79S6VkiyE3gchu4rIHLTeASqubTq_OiV86-Kf4kXAG2BXJdhUeX_j79f9cXUHGKiw</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Herghelegiu, Anna Marie</creator><creator>Nacu, Raluca Mihaela</creator><creator>Prada, Gabriel Ioan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Metabolic parameters and cognitive function in a cohort of older diabetic patients</title><author>Herghelegiu, Anna Marie ; Nacu, Raluca Mihaela ; Prada, Gabriel Ioan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-bba6ebd5cd5440d099b11cf38d7df20cdbc752bf4b75b70219446181fe02d0243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Mass Index</topic><topic>Cholesterol, LDL - analysis</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Dementia</topic><topic>Dementia - blood</topic><topic>Dementia - diagnosis</topic><topic>Dementia - epidemiology</topic><topic>Dementia - physiopathology</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - psychology</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Geriatrics/Gerontology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Intelligence Tests</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Original Article</topic><topic>Prevalence</topic><topic>Romania - epidemiology</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herghelegiu, Anna Marie</creatorcontrib><creatorcontrib>Nacu, Raluca Mihaela</creatorcontrib><creatorcontrib>Prada, Gabriel Ioan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herghelegiu, Anna Marie</au><au>Nacu, Raluca Mihaela</au><au>Prada, Gabriel Ioan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic parameters and cognitive function in a cohort of older diabetic patients</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>28</volume><issue>6</issue><spage>1105</spage><epage>1112</epage><pages>1105-1112</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understood.
Aims
The main objective of this study was to investigate the relationship between metabolic parameters and the cognitive function in older diabetics.
Methods
A total number of 360 diabetic subjects, age 65 years and over, and 300 older people controls were included. Clinical and biological parameters, together with the cognitive function, were assessed every 6 months over a 18-month period, for each study participant.
Results
By employing a multivariate linear regression analysis, several significant relationships have been identified: between Clock Drawing Test (CDT) scores and HbA1c (
R
2
= 0.68); between CDT scores (
R
2
= 0.51) and overall MMSE scores (
R
2
= 0.43) on one hand, and DM duration in years, on the other hand; also between CDT scores and BMI (
R
2
= 0.59). There was no significant association between fasting serum glucose (FSG), total serum cholesterol, LDL cholesterol or triglycerides levels and cognitive function scores (
p
> 0.05).
Conclusions
The close detailed monitoring of the cognitive function and a rigorous metabolic control are important, especially in the very early stages of DM. Addressing factors such as weight control in older diabetic patients could contribute to better cognitive outcomes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26727913</pmid><doi>10.1007/s40520-015-0515-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8319 |
| ispartof | Aging clinical and experimental research, 2016-12, Vol.28 (6), p.1105-1112 |
| issn | 1720-8319 1594-0667 1720-8319 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Aged, 80 and over Body Mass Index Cholesterol, LDL - analysis Cognition - physiology Cognitive ability Comorbidity Dementia Dementia - blood Dementia - diagnosis Dementia - epidemiology Dementia - physiopathology Diabetes Diabetes Mellitus - blood Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Diabetes Mellitus - psychology Female Geriatric Assessment Geriatrics/Gerontology Glycated Hemoglobin A - analysis Humans Intelligence Tests Male Medicine Medicine & Public Health Metabolism Original Article Prevalence Romania - epidemiology Statistics as Topic |
| title | Metabolic parameters and cognitive function in a cohort of older diabetic patients |
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