Differential modulation of claudin 4 expression and myosin light chain phosphorylation by thyroid function in lung injury

Background Trauma and ventilator‐induced lung injury is often associated with endothelial–epithelial barriers breakdown, which may lead to multiple system organ failure (MSOF) and death in critically ill patients. Although molecular mechanism involved in MSOF is not known, junctional opening is beli...

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Veröffentlicht in:	The clinical respiratory journal 2017-11, Vol.11 (6), p.797-804
Hauptverfasser:	Varedi, Masoumeh, Pajouhi, Naser, Owji, Mohammad, Naghibalhossaini, Fakhraddin, Omrani, Gholam H. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals claudin Claudin-4 Critical Illness - mortality Endothelium - injuries Endothelium - pathology epithelial barrier Humans lung injury Lung Injury - metabolism Lung Injury - mortality Lung Injury - pathology Lung Injury - veterinary Male Models, Animal Multiple Organ Failure - etiology myosin light chain Myosin Light Chains - metabolism Phosphorylation Proteins Rats Rats, Sprague-Dawley Respiration, Artificial - adverse effects Respiration, Artificial - utilization thyroid Thyroid gland Thyroid Gland - metabolism Thyroid Gland - physiology Thyroid Hormones - metabolism Thyroid Hormones - physiology Tight Junctions - metabolism Trauma
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